(n.) An invitation to engage in a contest or controversy of any kind; a defiance; specifically, a summons to fight a duel; also, the letter or message conveying the summons.
(n.) The act of a sentry in halting any one who appears at his post, and demanding the countersign.
(n.) A claim or demand.
(n.) The opening and crying of hounds at first finding the scent of their game.
(n.) An exception to a juror or to a member of a court martial, coupled with a demand that he should be held incompetent to act; the claim of a party that a certain person or persons shall not sit in trial upon him or his cause.
(n.) An exception to a person as not legally qualified to vote. The challenge must be made when the ballot is offered.
(n.) To call to a contest of any kind; to call to answer; to defy.
(n.) To call, invite, or summon to answer for an offense by personal combat.
(n.) To claim as due; to demand as a right.
(n.) To censure; to blame.
(n.) To question or demand the countersign from (one who attempts to pass the lines); as, the sentinel challenged us, with "Who comes there?"
(n.) To take exception to; question; as, to challenge the accuracy of a statement or of a quotation.
(n.) To object to or take exception to, as to a juror, or member of a court.
(n.) To object to the reception of the vote of, as on the ground that the person in not qualified as a voter.
(v. i.) To assert a right; to claim a place.
Example Sentences:
(1) Bronchial challenge caused an immediate asthmatic response.
(2) When chimeric animals were subjected to a lethal challenge of endotoxin, their response was markedly altered by the transferred lymphoid cells.
(3) This frees the student to experience the excitement and challenge of learning and the joy of helping people.
(4) The degree of increase in Meth responsiveness elicited by the initial provocation is a major factor in determining the airway response to a subsequent HS challenge.
(5) Intranasal challenge of allergic subjects with the allergen to which they are sensitive rapidly produces sneezing, rhinorrhea, and airway obstruction.
(6) Matthias Müller, VW’s chief executive, said: “In light of the wide range of challenges we are currently facing, we are satisfied overall with the start we have made to what will undoubtedly be a demanding fiscal year 2016.
(7) In 1935, Einstein challenged the prevailing interpretation of quantum theory.
(8) A shrinking populace is perhaps a greater challenge than any problems with Russia.
(9) Intraperitoneal injection of indomethacin to pretreated animals resulted in increased levels of IL-1 and TNF and decreased levels of PGE2 following challenge with E. coli.
(10) Think of Nelson Mandela – there is a determination, an unwillingness to bend in the face of challenges, that earns you respect and makes people look to you for guidance.
(11) The children's pulse, pulse rate variability, and blood pressure were then measured at rest and during a challenging situation.
(12) At first it looked as though the winger might have shown too much of the ball to the defence, yet he managed to gain a crucial last touch to nudge it past Phil Jones and into the path of Jerome, who slipped Chris Smalling’s attempt at a covering tackle and held off Michael Carrick’s challenge to place a shot past an exposed De Gea.
(13) The results support the notion that mediator lymphocytes circulate in tumor immunized rats in a noncytotoxic state, specifically recognize tumor cells at a challenge site, and mediate induction of effector cells locally.
(14) The role of blood acetylcholinesterase in moderating the effects of organophosphate challenge in rats was tested.
(15) In the first trial to investigate the effect of tick control, significant improvements in liveweight gain (LWG) occurred only in periods of medium to high challenge with adult Amblyomma variegatum.
(16) The SNT and the I-ELISA indicated that the pigs responded to vaccination and challenge.
(17) When caffeine evokes a contraction, and only then, crayfish muscle fibers become refractory to a second challenge with caffeine for up to 20 min in the standard saline (5 mM K(o)).
(18) This observation seriously challenges the hypothesis that SCE cancellation results as a consequence of persistence of the lesions induced by these agents.
(19) Injection of about four ImD 50 of vaccine intracerebrally produced a local immunity, resulting in an immediate kill of challenge organisms given 14 days later.
(20) There was no correlation between anti-TNP-precipitating antibody titer after sensitization and the ability to respond to challenge by hapten-heterologous carrier.
Difficult
Definition:
(a.) Hard to do or to make; beset with difficulty; attended with labor, trouble, or pains; not easy; arduous.
(a.) Hard to manage or to please; not easily wrought upon; austere; stubborn; as, a difficult person.
(v. t.) To render difficult; to impede; to perplex.
Example Sentences:
(1) Virtually every developed country has some form of property tax, so the idea that valuing residential property is uniquely difficult, or that it would be widely evaded, is nonsense.
(2) Although solely nociresponsive neurons are clearly likely to fill a role in the processing and signalling of pain in the conscious central nervous system, the way in which such useful specificity could be conveyed by multireceptive neurons is difficult to appreciate.
(3) In practice, however, the necessary dosage is difficult to predict.
(4) Cor triatriatum (CT) is a rare congenital defect, surgically correctable, and sometimes difficult to diagnose by cardiac catheterization.
(5) By drawing from the pathophysiology, this article discusses a multidimensional approach to the treatment of these difficult patients.
(6) Past imaging techniques shown in the courtroom have made the conventional rules of evidence more difficult because of the different informational content and format required for presentation of these data.
(7) The way we are going to pay for that is by making the rules the same for people who go into care homes as for people who get care at their home, and by means-testing the winter fuel payment, which currently isn’t.” Hunt said the plan showed the Conservatives were capable of making difficult choices.
(8) In many cases, physicians seek to protect themselves from involvement with these difficult, highly anxious patients by making a referral to a psychiatrist.
(9) The diagnosis of variant- or Prizmetal-angina is difficult because if insufficient specificity of the tests.
(10) The detection of these antibodies is difficult owing to the lack of standardization and of specificity of the laboratory tests.
(11) It was so difficult to keep a straight face when I was filming a sauna scene with Roy Barraclough, who played the mayor of Blackpool.
(12) That is, he believes, to look at massively difficult, interlocking problems through too narrow a lens.
(13) Conversion of the active-site thiol to thiocyanate makes it more difficult to inactivate the enzyme by treatment with Cd2+.
(14) If they end up going to another club that is difficult to take.
(15) Cigarette consumption has also been greater in urban areas, but it is difficult to estimate how much of the excess it can account for.
(16) The most difficult thing I've dealt with at work is ... the terminal illness of a valued colleague.
(17) In that respect, it's difficult to see Allen's anthem as little more than same old same old, and it's probably why I ultimately feel she misses the mark.
(18) This hypothesis is difficult to substantiate with direct measurements using human subjects.
(19) Extrapolation of gestational age from early crown-rump lengths (CRLs) has been difficult because previously established tables of CRL versus gestational age have contained few measurements at less than seven to eight weeks from the first day of the last menses.
(20) Companies had made investments in certain energy sources, the president said, so change could be “uncomfortable and difficult”.