(n.) The hollow bed where a stream of water runs or may run.
(n.) The deeper part of a river, harbor, strait, etc., where the main current flows, or which affords the best and safest passage for vessels.
(n.) A strait, or narrow sea, between two portions of lands; as, the British Channel.
(n.) That through which anything passes; means of passing, conveying, or transmitting; as, the news was conveyed to us by different channels.
(n.) A gutter; a groove, as in a fluted column.
(n.) Flat ledges of heavy plank bolted edgewise to the outside of a vessel, to increase the spread of the shrouds and carry them clear of the bulwarks.
(v. t.) To form a channel in; to cut or wear a channel or channels in; to groove.
(v. t.) To course through or over, as in a channel.
Example Sentences:
(1) These channels may, at least in some cases, be responsible for the generation of pacemaker depolarizations, thereby regulating firing behaviour.
(2) The influence of the various concepts for the induction of lateral structure formation in lipid membranes on integral functional units like ionophores is demonstrated by analysing the single channel current fluctuations of gramicidin in bimolecular lipid membranes.
(3) RNAs encoding a wild-type (RBK1) and a mutant (RBK1(Y379V,V381T); RBK1*) subunit of voltage-dependent potassium channels were injected into Xenopus oocytes.
(4) The dramas are part of the BBC2 controller Janice Hadlow's plans for her "unashamedly intelligent" channel over the coming months.
(5) This was unlike the action of the calcium channel blocker, cadmium, which reduced the calcium action potential and the a.h.p.
(6) Circuitry has been developed to feed the output of an ear densitogram pickup into one channel of a two-channel Holter monitor.
(7) It is concluded the decrease in cellular volume associated with substitution of serosal gluconate for Cl results in a loss of highly specific Ba2+-sensitive K+ conductance channels from the basolateral plasma membrane.
(8) Stimulation of atrial H1-receptors is suggested to directly cause an increase in Ca-channel conductance independent of intracellular cAMP content.
(9) Similarly, 50 microM D-600, a Ca+2 channel antagonist, significantly (P less than 0.01) reduced basal and 5-HETE-induced PRL release.
(10) The purpose of the present study was to analyze the effects of cromakalim (BRL 34915), a potent drug from a new class of drugs characterized as "K+ channel openers", on the electrical activity of human skeletal muscle.
(11) This promotion of repetitive activity by the introduction of additional potassium channels occurred up to an "optimal" value beyond which a further increase in paranodal potassium permeability narrowed the range of currents with a repetitive response.
(12) Channel activation persists through the process of platelet isolation and washing and is manifested in higher measured values of [Ca2+]cyt and [Ca2+]dt in the "resting state."
(13) At 100 microM-ACh the apparent open time became shorter probably due to channel blockade by ACh molecules.
(14) The effects of low doses of dihydropyridine (DHP) calcium channel antagonists nimodipine, nifedipine, (-)-R-202-791, and amlodipine, the DHP calcium channel agonist BAY K 8644 were investigated on clonic convulsions to pentylenetetrazole (PTZ) in mice.
(15) The following model is suggested: exogenous ATP interacts with a membrane receptor in the presence of Ca2+, a cascade of events occurs which mobilizes intracellular calcium, thereby increasing the cytosolic free Ca2+ concentration which consequently opens the calcium-activated K+ channels, which then leads to a change in membrane potential.
(16) SDS-PAGE analysis of the immunoprecipitates under reducing conditions revealed that the cardiac channel is mainly composed of two large polypeptides of 190 and 150 kDa, and five smaller polypeptides of 60, 55, 35, 30, and 25 kDa.
(17) In the presence of high external Cl, a component of outward current that was inhibited by the anion channel blocker diphenylamine-2-carboxylate (DPC) appeared in 70% of the cells.
(18) In vitro studies in cardiac Purkinje fibers suggested that reversal of amitriptyline-induced cardiac membrane effects by sodium bicarbonate may be attributed not only to alkalinization but also to increased in extracellular sodium concentration, diminishing the local anesthetic action of amitriptyline and resulting in less sodium channel block.
(19) The Ca2+ channel current recorded under identical conditions in rat dorsal root ganglion neurones was less sensitive to blockade by PCP (IC50, 90 microM).
(20) In voltage-clamp experiments the ion current flowing through the channels was homogeneous indicating a defined conformation and a uniform size.
Gutter
Definition:
(n.) A channel at the eaves of a roof for conveying away the rain; an eaves channel; an eaves trough.
(n.) A small channel at the roadside or elsewhere, to lead off surface water.
(n.) Any narrow channel or groove; as, a gutter formed by erosion in the vent of a gun from repeated firing.
(v. t.) To cut or form into small longitudinal hollows; to channel.
(v. t.) To supply with a gutter or gutters.
(v. i.) To become channeled, as a candle when the flame flares in the wind.
Example Sentences:
(1) This is basically a large tank (the bigger the better) that collects rain from the house guttering and pumps it into the home, to be used for flushing the loo.
(2) These lanes encourage cyclists to 'ride in the gutter' which in itself is a very dangerous riding position – especially on busy congested roads as it places the cyclist right in a motorist's blind spot.
(3) The size of presynaptic release site structures was determined by examining serial transverse sections through entire terminal branches with the transmission electron microscope; the size of postsynaptic release site structures was determined by examining terminal gutters with the scanning electron microscope after the removal of terminal branches.
(4) Yes, Goldsmith is to be held in contempt: a man of decency would have rejected this gutter strategy.
(5) More time in bed, more time with the kids, more time to read, see your mum, hang out with friends, repair the guttering, make music, fix lunch, walk in the park.
(6) Had they bothered to inquire of a veteran from the ranks, they might have heard how exasperating it is to see the dainty long-range patriots of Labour thrashing it out with the staunch gutter jingoists of the Conservative party – and barely a non-commissioned vet among them.
(7) No clear gross or histological distinctions between the ventricular "candle gutterings" and "tumors" have been identified.
(8) Most transposed ovaries were located along the paracolic gutters near the iliac crests, creating an extrinsic mass effect on adjacent bowel.
(9) Golf balls, bottles, fireworks, umbrellas and even cast iron rain gutter was thrown at republicans marching along Royal Avenue.
(10) !— she wants you to put out the bins and clear the gutters of leaves like you’ve been promising to do for six months.
(11) A one-piece integral tube and plate with a slit-valve mechanism designed to regulate post-operative intraocular pressure had a very variable response in 27 eyes, with mean pressures similar to those after unligated tube and gutters.
(12) Blood gutters brightly against his green gown, yet the man doesn't shudder or stagger or sink but trudges towards them on those tree-trunk legs and rummages around, reaches at their feet and cops hold of his head and hoists it high, and strides to his steed, snatches the bridle, steps into the stirrup and swings into the saddle still gripping his head by a handful of hair.
(13) In the second, density would decrease from the crest border, where the value was that of the gutter edge, to the fold end, where the value would be 50% lower.
(14) Following the sting, Ferguson apologised for a “serious lapse of judgment” and told the US talkshow host Oprah Winfrey she had been drinking and was “in the gutter at that moment”.
(15) The characteristics of the innervation revealed by the cholinesterase activity, concentrated in the synaptic gutters and the direct study of the nerve fibres, show focal, mono-axonal 'en plaques' endings, typical of the phasic motor system.
(16) The flame of ultra Serb nationalism appears to be guttering, although it could be replaced with a quieter long-lasting resentment.
(17) For larger exposure of the artery, the foramen transversarium of C1 must be unroofed and the artery dissected in the guttering of the posterior arch of the atlas.
(18) In a surgical technique termed ovarian transposition, the ovary is repositioned to the iliac fossa or paracolic gutter outside the radiation field.
(19) That “trollumnist” Mark Latham, that “misogynist”, “venal”, “crazy-eyed moron” whose views should be “rejected and dismantled and kicked into the gutter where they belong” has resigned from the Australian Financial Review.
(20) This comes from a man who insisted on a mass cull of badgers against scientific advice , who stripped away the last regulations protecting the soil from erosion , who believed that “ the purpose of waterways is to get rid of water ” and sought to turn our rivers into featureless gutters ,and who championed the pesticides that appear to be destroying bees and other animals .