(n.) The hollow bed where a stream of water runs or may run.
(n.) The deeper part of a river, harbor, strait, etc., where the main current flows, or which affords the best and safest passage for vessels.
(n.) A strait, or narrow sea, between two portions of lands; as, the British Channel.
(n.) That through which anything passes; means of passing, conveying, or transmitting; as, the news was conveyed to us by different channels.
(n.) A gutter; a groove, as in a fluted column.
(n.) Flat ledges of heavy plank bolted edgewise to the outside of a vessel, to increase the spread of the shrouds and carry them clear of the bulwarks.
(v. t.) To form a channel in; to cut or wear a channel or channels in; to groove.
(v. t.) To course through or over, as in a channel.
Example Sentences:
(1) These channels may, at least in some cases, be responsible for the generation of pacemaker depolarizations, thereby regulating firing behaviour.
(2) The influence of the various concepts for the induction of lateral structure formation in lipid membranes on integral functional units like ionophores is demonstrated by analysing the single channel current fluctuations of gramicidin in bimolecular lipid membranes.
(3) RNAs encoding a wild-type (RBK1) and a mutant (RBK1(Y379V,V381T); RBK1*) subunit of voltage-dependent potassium channels were injected into Xenopus oocytes.
(4) The dramas are part of the BBC2 controller Janice Hadlow's plans for her "unashamedly intelligent" channel over the coming months.
(5) This was unlike the action of the calcium channel blocker, cadmium, which reduced the calcium action potential and the a.h.p.
(6) Circuitry has been developed to feed the output of an ear densitogram pickup into one channel of a two-channel Holter monitor.
(7) It is concluded the decrease in cellular volume associated with substitution of serosal gluconate for Cl results in a loss of highly specific Ba2+-sensitive K+ conductance channels from the basolateral plasma membrane.
(8) Stimulation of atrial H1-receptors is suggested to directly cause an increase in Ca-channel conductance independent of intracellular cAMP content.
(9) Similarly, 50 microM D-600, a Ca+2 channel antagonist, significantly (P less than 0.01) reduced basal and 5-HETE-induced PRL release.
(10) The purpose of the present study was to analyze the effects of cromakalim (BRL 34915), a potent drug from a new class of drugs characterized as "K+ channel openers", on the electrical activity of human skeletal muscle.
(11) This promotion of repetitive activity by the introduction of additional potassium channels occurred up to an "optimal" value beyond which a further increase in paranodal potassium permeability narrowed the range of currents with a repetitive response.
(12) Channel activation persists through the process of platelet isolation and washing and is manifested in higher measured values of [Ca2+]cyt and [Ca2+]dt in the "resting state."
(13) At 100 microM-ACh the apparent open time became shorter probably due to channel blockade by ACh molecules.
(14) The effects of low doses of dihydropyridine (DHP) calcium channel antagonists nimodipine, nifedipine, (-)-R-202-791, and amlodipine, the DHP calcium channel agonist BAY K 8644 were investigated on clonic convulsions to pentylenetetrazole (PTZ) in mice.
(15) The following model is suggested: exogenous ATP interacts with a membrane receptor in the presence of Ca2+, a cascade of events occurs which mobilizes intracellular calcium, thereby increasing the cytosolic free Ca2+ concentration which consequently opens the calcium-activated K+ channels, which then leads to a change in membrane potential.
(16) SDS-PAGE analysis of the immunoprecipitates under reducing conditions revealed that the cardiac channel is mainly composed of two large polypeptides of 190 and 150 kDa, and five smaller polypeptides of 60, 55, 35, 30, and 25 kDa.
(17) In the presence of high external Cl, a component of outward current that was inhibited by the anion channel blocker diphenylamine-2-carboxylate (DPC) appeared in 70% of the cells.
(18) In vitro studies in cardiac Purkinje fibers suggested that reversal of amitriptyline-induced cardiac membrane effects by sodium bicarbonate may be attributed not only to alkalinization but also to increased in extracellular sodium concentration, diminishing the local anesthetic action of amitriptyline and resulting in less sodium channel block.
(19) The Ca2+ channel current recorded under identical conditions in rat dorsal root ganglion neurones was less sensitive to blockade by PCP (IC50, 90 microM).
(20) In voltage-clamp experiments the ion current flowing through the channels was homogeneous indicating a defined conformation and a uniform size.
Part
Definition:
(n.) One of the portions, equal or unequal, into which anything is divided, or regarded as divided; something less than a whole; a number, quantity, mass, or the like, regarded as going to make up, with others, a larger number, quantity, mass, etc., whether actually separate or not; a piece; a fragment; a fraction; a division; a member; a constituent.
(n.) An equal constituent portion; one of several or many like quantities, numbers, etc., into which anything is divided, or of which it is composed; proportional division or ingredient.
(n.) A constituent portion of a living or spiritual whole; a member; an organ; an essential element.
(n.) A constituent of character or capacity; quality; faculty; talent; -- usually in the plural with a collective sense.
(n.) Quarter; region; district; -- usually in the plural.
(n.) Such portion of any quantity, as when taken a certain number of times, will exactly make that quantity; as, 3 is a part of 12; -- the opposite of multiple. Also, a line or other element of a geometrical figure.
(n.) That which belongs to one, or which is assumed by one, or which falls to one, in a division or apportionment; share; portion; lot; interest; concern; duty; office.
(n.) One of the opposing parties or sides in a conflict or a controversy; a faction.
(n.) A particular character in a drama or a play; an assumed personification; also, the language, actions, and influence of a character or an actor in a play; or, figuratively, in real life. See To act a part, under Act.
(n.) One of the different melodies of a concerted composition, which heard in union compose its harmony; also, the music for each voice or instrument; as, the treble, tenor, or bass part; the violin part, etc.
(n.) To divide; to separate into distinct parts; to break into two or more parts or pieces; to sever.
(n.) To divide into shares; to divide and distribute; to allot; to apportion; to share.
(n.) To separate or disunite; to cause to go apart; to remove from contact or contiguity; to sunder.
(n.) Hence: To hold apart; to stand between; to intervene betwixt, as combatants.
(n.) To separate by a process of extraction, elimination, or secretion; as, to part gold from silver.
(n.) To leave; to quit.
(v. i.) To be broken or divided into parts or pieces; to break; to become separated; to go asunder; as, rope parts; his hair parts in the middle.
(v. i.) To go away; to depart; to take leave; to quit each other; hence, to die; -- often with from.
(v. i.) To perform an act of parting; to relinquish a connection of any kind; -- followed by with or from.
(v. i.) To have a part or share; to partake.
(adv.) Partly; in a measure.
Example Sentences:
(1) We used the polymerase chain reaction (PCR) to amplify the breakpoint area of alpha-thalassemia-1 of Southeast Asia type and several parts of the alpha-globin gene cluster to make a differential diagnosis between alpha-thalassemia-1 and Hb Bart's hydrops fetalis.
(2) We attribute this in part to early diagnosis by computed tomography (CT), but a contributory factor may be earlier referrals from country centres to a paediatric trauma centre and rapid transfer, by air or road, by medical retrieval teams.
(3) The process of sequence rearrangement appears to be a significant part of the evolution of the genome and may have a much greater effect on the evolution of the phenotype than sequence alteration by base substitution.
(4) These results show that the pathogenic phenotypes of MCF viruses are dissociable from the thymotropic phenotype and depend, at least in part, upon the enhancer sequences.
(5) However, medicines have an important part to play, and it is now generally agreed that for the very poor populations medicines should be restricted to those on an 'essential drugs list' and should be made available as cheaply as possible.
(6) Because cystine in medium was converted rapidly to cysteine and cysteinyl-NAC in the presence of NAC and given that cysteine has a higher affinity for uptake by EC than cystine, we conclude that the enhanced uptake of radioactivity was in the form of cysteine and at least part of the stimulatory effect of NAC on EC glutathione was due to a formation of cysteine by a mixed disulfide reaction of NAC with cystine similar to that previously reported for Chinese hamster ovarian cells (R. D. Issels et al.
(7) At operation, the tumour was identified and excised with part of the aneurysmal wall.
(8) However, ticks, which failed to finish their feeding and represent a disproportionately great part of the whole parasite's population, die together with them and the parasitic system quickly restores its stability.
(9) Muscle weakness and atrophy were most marked in the distal parts of the legs, especially in the gastrocnemius and soleus muscles, and then spread to the thighs and gluteal muscles.
(10) Despite of the increasing diagnostic importance of the direct determination of the parathormone which is at first available only in special institutions in these cases methodical problems play a less important part than the still not infrequent appearing misunderstanding of the adequate basic disease.
(11) This modulation results from repetitive, alternating bursts of excitatory and inhibitory postsynaptic potentials, which are caused at least in part by synaptic feedback to the command neurons from identified classes of neurons in the feeding network.
(12) Results show diet, self-control and parts of insulin-therapy to be problematic treatment components.
(13) Further analysis with two other synthetic peptides (212Cys to 222Glu and Cys X 221Ile to 236Glu) indicated that the dodecapeptide Ile-Glu-Phe-Gln-Lys-Asn-Asn-Arg-Leu-Leu-Glu mimicked either the whole or a major part of the neutralization epitope.
(14) Schneiderlin, valued at an improbable £27m, and the currently injured Jay Rodriguez are wanted by their former manager Mauricio Pochettino at Spurs, but the chairman Ralph Krueger has apparently called a halt to any more outgoings, saying: “They are part of the core that we have decided to keep at Southampton.” He added: “Jay Rodriguez and Morgan Schneiderlin are not for sale and they will be a part of our club as we enter the new season.” The new manager Ronald Koeman has begun rebuilding by bringing in Dusan Tadic and Graziano Pellè from the Dutch league and Krueger said: “We will have players coming in, we will make transfers to strengthen the squad.
(15) Patrice Evra Evra Handed a five-match international ban for his part in the France squad’s mutiny against Raymond Domenech at the 2010 World Cup, it took Evra almost a year to force his way back in.
(16) The dramas are part of the BBC2 controller Janice Hadlow's plans for her "unashamedly intelligent" channel over the coming months.
(17) The method is based on two-dimensional scanning photon absorptiometry on the distal part of the forearm.
(18) McDonald said cutting better deals with suppliers and improving efficiency as well as raising some prices had only partly offset the impact of sterling’s fall against the dollar.
(19) A strong block to the elongation of nascent RNA transcripts by RNA polymerase II occurs in the 5' part of the mammalian c-fos proto-oncogene.
(20) Anytime they feel parts of the Basic Law are not up to their current standards of political correctness, they will change it and tell Hong Kong courts to obey.