(n.) A powerful alkaloid, C17H21NO4, obtained from the leaves of coca. It is a bitter, white, crystalline substance, and is remarkable for producing local insensibility to pain.
Example Sentences:
(1) Altogether, 29% of the drivers had evidence of alcohol, marijuana, cocaine, prescription or nonprescription stimulants, or some combination of these, in either blood or urine.
(2) Mechanisms of drug toxicity, i.e., vascular pathology demonstrated from chronic use of cocaine.
(3) With chronic cocaine use, neurotransmitter and neuroendocrine alterations occur.
(4) In pentobarbital-anesthetized rats or in perfused hind paw of rats, the potentiation induced by cocaine and tripelennamine was more marked to norepinephrine than to epinephrine, but an inverse relation between norepinephrine and epinephrine was observed in the potentiation by I and II.
(5) The disposition of radiolabeled cocaine in humans has been studied after three routes of administration: iv injection, nasal insufflation (ni, snorting), and smoke inhalation (si).
(6) When S+ followed cocaine, stereotyped bar-pressing developed with markedly increased responding during the remainder of the session.
(7) The effects were atropine-resistant and qualitatively similar to those seen with cocaine.
(8) Knowing the risks of transporting cocaine from Africa to the US, and given the slim profit margin, “tell me who will be doing that kind of deal?” Chigbo asked.
(9) Cocaine produces simple hallucinations, PCP can produce complex hallucinations analogous to a paranoid psychosis, while LSD produces a combination of hallucinations, pseudohallucinations and illusions.
(10) Inhibition of DNA synthesis by cocaine in developing brain was not secondary to ischemia, nor to local anesthesia, as alpha-adrenergic blockade with phenoxybenzamine afforded no protection, and lidocaine could not substitute for cocaine.
(11) Cocaine, 3 microM, shifted the noradrenaline concentration response curve to the left about 0.4 log units in all renal vessel groups, thus renal vascular smooth muscle sensitivity to noradrenaline was significantly greater in vessels from rats receiving CyA than in vessels from control rats.
(12) Similarities and differences in the sensitization induced by cocaine and amphetamine (which are though to have different mechanisms of actions although common behavioral outcomes) have not been thoroughly studied.
(13) However, they do indicate that cocaine is only a weak aversion-inducing agent.
(14) Driving-under-the-influence (DUI) offenders with either alcohol- or cocaine-related problems were studied.
(15) The cardiac risk of cocaine body packing was studied by means of continuous ECG monitoring in 13 cocaine body-packers during spontaneous elimination.
(16) We present a 16-year-old with chest pain temporally related to cocaine use and discuss the relationship between cocaine use and acute myocardial infarction that has been seen in the adult population.
(17) Both acute and chronic cocaine treatments significantly increased plasma concentrations of corticosterone and reduced the ratios of 3,4-dihydroxyphenylacetic acid to dopamine and 5-hydroxyindoleacetic acid to serotonin in several brain regions.
(18) Daily cocaine injection into rodents produces a progressive increase in the motor stimulant effect of acute cocaine administration.
(19) The nine cocaine users, when compared with 14 insulin-dependent diabetics on dialysis matched by protocol, were found to be similar in terms of diabetic retinopathy and metabolic neuropathy.
(20) In view of recent reports demonstrating that illicit cocaine use may cause rhabdomyolysis, we reviewed the collective experience of a university-affiliated medical center to identify patients with cocaine-induced rhabdomyolysis.
Crack
Definition:
(v. t.) To break or burst, with or without entire separation of the parts; as, to crack glass; to crack nuts.
(v. t.) To rend with grief or pain; to affect deeply with sorrow; hence, to disorder; to distract; to craze.
(v. t.) To cause to sound suddenly and sharply; to snap; as, to crack a whip.
(v. t.) To utter smartly and sententiously; as, to crack a joke.
(v. t.) To cry up; to extol; -- followed by up.
(v. i.) To burst or open in chinks; to break, with or without quite separating into parts.
(v. i.) To be ruined or impaired; to fail.
(v. i.) To utter a loud or sharp, sudden sound.
(v. i.) To utter vain, pompous words; to brag; to boast; -- with of.
(n.) A partial separation of parts, with or without a perceptible opening; a chink or fissure; a narrow breach; a crevice; as, a crack in timber, or in a wall, or in glass.
(n.) Rupture; flaw; breach, in a moral sense.
(n.) A sharp, sudden sound or report; the sound of anything suddenly burst or broken; as, the crack of a falling house; the crack of thunder; the crack of a whip.
(n.) The tone of voice when changed at puberty.
(n.) Mental flaw; a touch of craziness; partial insanity; as, he has a crack.
(n.) A crazy or crack-brained person.
(n.) A boast; boasting.
(n.) Breach of chastity.
(n.) A boy, generally a pert, lively boy.
(n.) A brief time; an instant; as, to be with one in a crack.
(n.) Free conversation; friendly chat.
(a.) Of superior excellence; having qualities to be boasted of.
Example Sentences:
(1) They’re no crack force either; many are rather portly!
(2) While superheroes like “superman” (21st in SplashData’s 2014 rankings) and “batman” (24th) may be popular choices for passwords, the results if they are cracked could be anything other than super – and users will only have themselves to blame.
(3) However, we have observed cracks on the Dacron fibers, fiber fracture, fiber protrusion, and poor attachment to the diaphragm, which can cause potentially disastrous complications.
(4) But instead, he is going to crack under public anger over the huge amounts senior bankers have been paying themselves.
(5) It is found that, in contrast to most metallic materials yet in keeping with many ceramics, there are no distinct fracture morphologies in pyro-carbons which are characteristic of a specific mode of loading; fracture surfaces appear to be identical for both catastrophic and subcritical crack growth under either sustained or cyclic loading.
(6) Iowa senator Chuck Grassley, the Republican who chairs the Senate judiciary committee, introduced legislation on Tuesday that would crack down on jurisdictions that provide safe harbor for undocumented migrants by withholding some federal funding for state and local entities if they decline to cooperate with the government on the holding or transferring of undocumented migrants with criminal records.
(7) In a single letter in February 2005, Charles urged a badger cull to prevent the spread of bovine tuberculosis – damning opponents to the cull as “intellectually dishonest”; lobbied for his preferred person to be appointed to crack down on the mistreatment of farmers by supermarkets; proposed his own aide to brief Downing Street on the design of new hospitals; and urged Blair to tackle an EU directive limiting the use of herbal alternative medicines in the UK.
(8) On second impacts, the GSI rose considerably because the shell and liner of the DH-151 cracked and the suspension of the "141" stretched during the first blow.
(9) 9.18pm: The Ohio Democrat Dennis Kucinich has a crack, and he's taking no prisoners: "We've heard Mr Toyoda say that Toyota grew to fast.
(10) Here come the Dodgers for another crack at it in the second.
(11) That led to the second breakthrough, as the once formidable laws of omerta - silence punishable by death - cracked.
(12) The passengers were then flown to an Australian icebreaker, the Aurora Australis, which had cracked through ice floes and was now sailing towards Australia's Casey research base.
(13) SEM of the resulting surface showed rounded fragments of enamel rods, enamel melting, cracks, and smooth-edged voids.
(14) According to the NYPD commissioner, Bill Bratton, whose voice almost cracked with emotion as he addressed the media on Saturday evening , the “digital warning poster” featuring a picture of Brinsley and his whereabouts arrived at the data centre at 2.47pm.
(15) As subcritical crack velocities under cyclic loading were found to be many orders of magnitude faster than those measured under equivalent monotonic loads and to occur at typically 45% lower stress-intensity levels, cyclic fatigue in pyrolytic carbon-coated graphite is reasoned to be a vital consideration in the design and life-prediction procedures of prosthetic devices manufactured from this material.
(16) It is hence impossible to wiretap, intercept or crack the information transmitted through it,” Xinhua reported after Tuesday’s launch.
(17) He just never dreamed it would be life without parole.” Obama reduces sentences of 46 inmates convicted of nonviolent drug crimes Read more As his sister put it, Bennett “got caught up” in a five-man drug ring run by an old friend, John Hansley, to pay for his addiction to crack.
(18) Spencer has now heard that Andy, who got the boat remember, has been cracking on to Louise, even though Jamie warned him it would be like jumping into a polar bear's nest.
(19) "I urge both the monks and the lay Tibetans of the area not to do anything that might be used as a pretext by the local authorities to massively crack down on them.
(20) Of 26 patients treated to date, 16 have been crack cocaine users.