(v. t.) To break into pieces; to crush; to grind to powder. See Crase.
(v. t.) To weaken; to impair; to render decrepit.
(v. t.) To derange the intellect of; to render insane.
(v. i.) To be crazed, or to act or appear as one that is crazed; to rave; to become insane.
(v. i.) To crack, as the glazing of porcelain or pottery.
(n.) Craziness; insanity.
(n.) A strong habitual desire or fancy; a crotchet.
(n.) A temporary passion or infatuation, as for same new amusement, pursuit, or fashion; as, the bric-a-brac craze; the aesthetic craze.
Example Sentences:
(1) The coroner, Alan Craze, blamed poor communication and lack of organisation for the death of Lance Corporal Michael Pritchard, who was killed by a gunshot wound to the chest and abdomen in the "blue on blue" incident in Helmand province.
(2) But last week's trading statement from Unilever confirmed that, far from cashing in on the dieting craze, Slim Fast's sales have been shrinking faster than a weight watcher's waistline.
(3) A campaign involving children in Syrian villages has latched on to the Pokémon Go craze, asking gamers in the west to take a break from their frenzied hunt for digital creatures to turn their attention to young people trapped in war zones.
(4) Picture Detroit today and the images that probably come to mind are of " ruin porn " (the now infamous term for beautifully shot photos of dilapidated buildings); urban exploring (the new craze of creeping around abandoned complexes as seen in Jim Jarmusch's new film Only Lovers Left Alive ) and foreclosure frenzy (there are now nearly 80,000 empty homes to be torn down or fixed up in Motor City).
(5) ‘Twosie’ trend takes off Primark is backing the “twosie” as this year’s Christmas novelty hit in the UK, just as 2012’s craze the onesie has crossed the Channel in a late surge of popularity on the continent.
(6) The fashionable did not invent the craze for sunbathing, as we've been encouraged to believe.
(7) Sprawling across 110 hectares on the outskirts of Milan, this crazed collage of undulating tents, tilting green walls and parametrically-contorted lumps can mean only one thing: Expo 2015, latest in a long and controversial tradition of “world’s fairs”, has landed.
(8) Jimi Heselden, who latched on to an international craze for the upright, motorised "green commuter machines", was testing a cross-country version when he skidded into the river Wharfe which runs beside his Yorkshire estate.
(9) The tabloid conclusion is that the North's leaders are crazed – Kim Jong-un is a "deranged despot", the Sun wrote on Friday – while the Team America version is that they are idiotic.
(10) As the leader of the skiffle craze, he inspired the formation of literally thousands of do-it-yourself bands across the country, and was directly responsible for the 1960s pop explosion that - ironically - was to severely damage his own career.
(11) Knuckles, who is credited to have invented the house genre, begun his residency at the westside club in 1977 at the height of disco fever, but by 1980 a backlash had swept the craze away.
(12) Delivering his verdict after a week-long inquest, Craze said Pritchard's death was an accident, albeit an avoidable one.
(13) But there was a tonic for collective despair: from the decaying motor town of Coventry, 2 Tone Records promoted a "black and white, unite and fight" stance while launching a fashion, dance and musical craze that peaked with the 1981 summer of riots.
(14) He tried to capture its character – which he described as a “diabolical contraption, a dusty hunk of electric and mechanical hardware that reminded me of the disturbing 1950’s Quatermass science fiction television series” – in a near-lifesize two metre by three metre Portrait of a Dead Witch, which he also intended as a joke about the contemporary craze for computer-generated art.
(15) Their threat to sweep across continents like the armies of Muhammad, to stable their horses in the Vatican, are crazed delusions, we should not amplify them.
(16) The positive aspect is that far from being driven by a crazed, Hitler-like quest for European domination, the objectives of the Putin government appear to be both limited and rational: the protection of its regional security interests and great power status.
(17) Nowhere is the Sarah Brown craze more feverish than on the internet.
(18) #Bellfie by Matt Collins, managing director at Platypus Digital The big craze for 2015 will be the #bellfie.
(19) However, the larger apatite crystal size and loss of prismatic structure in crazed and cratered areas may partly explain previous observations of reduced rates of subsurface demineralization in lased enamel.
(20) "Obviously it doesn't fit into the paper cut-out picture of what a celebrity should look like," Cherry says, "and I think the whole scenario has become really crazed.
Fad
Definition:
(n.) A hobby ; freak; whim.
Example Sentences:
(1) Either reagent dislocates FAD from the holoenzyme, leaving a characteristic mercaptide derivative of the apoenzyme.
(2) After restrained least-squares refinement of the enzyme-substrate complex with the riboflavin omitted from the model, additional electron density appeared near the pyrophosphate, which indicated the presence of an ADPR molecule in the FAD binding site of PHBH.
(3) RR spectra of fatty acyl-CoA and its complexes are consistent with the previous hypothesis that visible spectral shifts observed during formation of acetoacetyl-CoA and crotonyl-CoA complexes of fatty acyl-CoA dehydrogenase result from charge-transfer interactions in which the ground state is essentially nonbonding as opposed to interactions in which complete electron transfer occurs to form FAD semiquinone.
(4) Her full name is Kitty White, and she has a family and lives in London (due to a Japanese fad for all things British in the mid-1970s).
(5) D-Amino acid oxidase purified from the yeast Rhodotorula gracilis is a flavoenzyme which does not require exogenous FAD for maximum activity.
(6) Flavin adenine dinucleotide (FAD) was covalently attached to an electron-conducting support, i.e., glassy carbon.
(7) Transient kinetic analysis for the interaction of MCAD-FAD with IACoA suggests that the formation of the enzyme-IACoA complex proceeds in two steps.
(8) Alignment of these sequences with that of squash defines domains of nitrate reductase that appear to bind its 3 prosthetic groups (molybdopterin, heme-iron, and FAD).
(9) With so many superfoods jostling for attention in the media and on supermarket shelves, it’s not always easy to separate the fad from the genuinely healthy.
(10) The depth of FAD incorporation into the enzyme molecule as calculated according to the outer sphere electron transfer theory is 6.1 A.
(11) The half-life of the solubilized oxidoreductase stored at 2-4 degrees C in the presence of 25% glycerol at pH 8.6 is approximately 30 h. The oxidoreductase contains a flavoprotein identifiable by its fluorescence spectrum for FAD which binds weakly to concanavalin A-Sepharose and elutes from gel sieving columns at a molecular weight range of approximately 51,000.
(12) Lifetime risk of dementia in early-onset FAD kindreds is consistent with an autosomal dominant inheritance model.
(13) Thus, ETF appears to contain one flavin (at least 90% FAD, by chromatographic and fluorescence characteristics) per 26,000 M-r, and therefore may be composed of two subunits with one flavin each.
(14) Microcoulometric titrations of NADH:nitrate reductase at 25 degrees C in Mops buffer, pH 7.0, showed that the native enzyme, containing functional FAD, haem and Mo, required addition of five electrons for complete reduction.
(15) An automated AutoAnalyzer method using 5:5'-dithiobis-2-nitrobenzoic acid is described for determining whole blood glutathione reductase (BGR) activity and for measuring in vitro activation of BGR with flavin adenine dinucleotide (FAD).
(16) The kinetic course of the reaction of methanol and deutero-methanol with FAD-dependent alcohol oxidase was investigated under single-turnover conditions [kred approximately equal to 15000 min-1 (1H3COH) and approximately equal to 4300 min-1 (2H3COH)] and multiple-turnover conditions [TNmax approximately equal to 6000 min-1 (1H3COH) and approximately equal to 3100 min-1 (2H3COH)].
(17) It had been shown that thyroxine regulates the conversion of riboflavin to riboflavin mononucleotide and flavin adenine dinucleotide (FAD) in laboratory animals.
(18) The value of P of the enzyme is dependent on its concentration, indicating that the degrees of dissociation of FAD in the monomer and dimer are different.
(19) We now provide evidence for a major early onset FAD locus on the long arm of chromosome 14 near the markers D14S43 and D14S53 (multipoint lod score z = 23.4) and suggest that the inheritance of FAD may be more complex than had initially been suspected.
(20) Thus, the low activity resulting from an inherited deficiency of FAD is decreased further.