(n.) The creaking of a door, or a noise resembling it.
(n.) A painful, spasmodic affection of the muscles of some part of the body, as of the neck or back, rendering it difficult to move the part.
(n.) A small jackscrew.
Example Sentences:
(1) This suggests that (AGG)12 can form intra- and inter-molecular complexes by non-Watson-Crick, guanine:guanine base-pairing.
(2) It is demonstrated that this peculiar DNA fragment, under suitable conditions of concentration, salt and temperature, exclusively prefers to adopt a monomeric hairpin form with a stem of three Watson-Crick type base pairs and a loop of two residues.
(3) Hope u feel better xx” Bird told Channel 4’s political editor Michael Crick: “Natasha Bolter and I were in a consensual relationship between 18 September and 2 November, well after her admission to the list of approved candidates.
(4) The new Francis Crick Institute in London, now filling with 1,400 scientists, could be built and run for 10 years on that.
(5) The Watson-Crick H-bonded imino proton resonances were studied.
(6) The Watson-Crick alignment of the alkylG.T and alkylT.G mispairs may facilitate formation of these phosphodiester links, and this alignment rather than the strength of the base pairs and the extent of hydrogen bonding between them may be the crucial factor in the miscoding.
(7) The complex has one drug molecule intercalated between Watson--Crick base pairs of the nucleotide duplex.
(8) Recognition of the UACUAAC box thus relies, at least in part, on Watson-Crick base pairing with the yeast U2 analogue.
(9) A characteristic of Watson-Crick paired A X T and G X C bases is the pseudo 2-fold symmetry axis in the plane of the base pairs.
(10) The imino proton of T3 in the O6meG.T 12-mer and G3 in the O6meG.N 12-mer helix, which are associated with the modification site, resonate at unusually high field (8.5 to 9.0 ppm) compared to imino protons in Watson-Crick base pairs (12.5 to 14.5 ppm).
(11) We’d get recognised when we went out, and I developed a bad crick in my spine because I was staring at the pavement so much.
(12) The base pairing between piA and poly(U) in this system is probably of the Hoogsteen type (involving the 6-amino group and N7 of 3-isoadenosine) rather than of the Watson-Crick type.
(13) One of these models is a four-strand structure in which two duplexes of the Watson-Crick kind are specifically related by a twofold rotation axis and which has already been discussed in some detail.
(14) Nurse, too, believes the Crick is built on solid foundations.
(15) Molecular modeling shows that a stereochemically satisfactory structure can be build using C2'-endo sugars and a displacement of the Watson-Crick base-pair center from the helix axis of 2.5 A. Helical constraints of rise per residue (h = 3.26 A) and residues per turn (n = 12) were taken from fiber diffraction experiments of Arnott and Selsing (1974).
(16) The temperature variation of the imino proton NMR signals suggests that the hydrogen bonding in self-recognition is comparable in strength with that in a beta-DNA duplex, and NOE data are in accord with Watson-Crick rather than Hoogsteen base pairing.
(17) We describe NMR studies at superconducting fields which characterize aspects of the structure and stability of the 1 : 2 actinomycin-d-pG-C complex in solution as monitored at the Watson-Crick base pairs and backbone phosphate groups.
(18) From fibre diffraction data, models for triplex structures with poly(U).poly(A).poly(U) and poly(dT).poly(dA).poly(dT) have been proposed, in which the purine and one pyrimidine strand are Watson-Crick paired in an A' helix, and the other pyrimidine strand is Hoogsteen base-paired parallel to the purine strand along the major groove.
(19) The peptide forms a parallel, two-stranded coiled coil of alpha helices packed as in the "knobs-into-holes" model proposed by Crick in 1953.
(20) 7.09pm: On his blog, Newsnight's Michael Crick quotes an unnamed Liberal Democrat MP who told him he was amazed how much the Tories were willing to compromise.
Cringe
Definition:
(v. t.) To draw one's self together as in fear or servility; to bend or crouch with base humility; to wince; hence; to make court in a degrading manner; to fawn.
(v. t.) To contract; to draw together; to cause to shrink or wrinkle; to distort.
(n.) Servile civility; fawning; a shrinking or bowing, as in fear or servility.
Example Sentences:
(1) One test he passed: he could say he loved his country, its values and its spirit without causing a toe-curling cringe.
(2) Inequality, precarity and social division are the causes of our new callousness, helped by the rightwing press, but the real point is that Labour has only two choices in response: either continue to cringe before the prejudices of the public or try to change their minds by arguing for a distinct, simple and compelling alternative.
(3) They cringed even more when I used the word “psychosomatic”.
(4) There’s no doubt there are large swaths within the industry who are committed to overturning this divisive hostility towards women, just as there are men who cringe at the term “brogrammer”.
(5) Second-chance Sunday in Gosford In truth, Justin Pasfield’s calamitous goalkeeping against Newcastle last week was about as cringe-worthy as his new hipster beard-haircut combination.
(6) But there are other dimensions to the Games that should be embraced without cringing.
(7) – rather than on the man’s indecent entitlement, grubbiness and criminality.” 'These women are not statistics' – deaths in Australia in 2015 Read more Surely Lay would cringe, then, at comments made by Victorian homicide squad head, detective inspector Mick Hughes, following the brutal and seemingly random killing of 17-year-old schoolgirl, Masa Vukotic, in broad daylight while she was out walking as part of her usual exercise routine.
(8) It also prompted a collective cringe from many in the Republican political establishment, which is now facing the prospect of losing control of the Senate and even the House because of the drag faced by down-ballot candidates campaigning into the headwinds of their presidential nominee.
(9) As baffling as it may be to those of us whose approach to music festivals is to wear the same clothes for the whole weekend, and to think anyone who bothers brushing their teeth is just trying to be fancy, somehow festivals have become – and I cringe so hard as I write this phrase – "trendsetters".
(10) I cringe when I hear our political leadership deliver yet another speech extolling a commitment to fighting extremism, yet in almost the time it takes to draw their next breath, go on to announce cuts to community services groups, the kind of organisations whose roles are vital in addressing the risk factors that leave one vulnerable to extremism.
(11) … You’re going to get what I think, whether you like it or not, whether it makes you cringe every once in a while or not.” Decrying “bickering leaders in Washington DC”, Christie held out his record as a fiscally conservative governor with a record early in his tenure of bipartisan victories as evidence of change he could bring to the national capital.
(12) The composer Charles Ives, for instance, spent his whole career in a sort of cringe, fearfully anticipating the accusation that to make music was a “sissy” activity.
(13) Sometimes I cringe at the lack of awareness of problems they’re causing other road users.
(14) Electrical stimulation of the superior colliculus in rats elicits not only orienting movements, as it does in other mammals, but also behaviours resembling such natural defensive responses as prolonged freezing, cringing, shying, and fast running and jumping.
(15) Nonetheless, some of Bashir's voters' views must be hard to stomach: informed that one of his voters had just told the Guardian that they were voting for Ukip "because Enoch Powell was right," he failed to suppress a cringe before saying: "The world is full of people of different persuasions.
(16) I cringed when I watched Abedin defend her husband Anthony Weiner in a press conference, as he asked New York City voters to support his campaign for mayor in spite of news reports of another sexting affair.
(17) Surely executives will hesitate to begin each sentence with bizarre jargon or a name-dropped reference to "Tony", now that they've cringed when Simon Harwood, Director of Strategic Governance, does it.
(18) People in my family cringe.” It’s too early to determine what impact Trump’s proposal will have, says Ackles, but he expects to hear more about hedge funds in the coming weeks.
(19) The shadow treasury team's response to Clegg's wealth tax proposal was an infantile ya-boo of the kind that makes voters cringe: "Nick Clegg is once again taking the British people for fools.
(20) I felt the mild elation and giggly cringe of executing a well-designed violent manoeuvre in a video game.