(n.) The creaking of a door, or a noise resembling it.
(n.) A painful, spasmodic affection of the muscles of some part of the body, as of the neck or back, rendering it difficult to move the part.
(n.) A small jackscrew.
Example Sentences:
(1) This suggests that (AGG)12 can form intra- and inter-molecular complexes by non-Watson-Crick, guanine:guanine base-pairing.
(2) It is demonstrated that this peculiar DNA fragment, under suitable conditions of concentration, salt and temperature, exclusively prefers to adopt a monomeric hairpin form with a stem of three Watson-Crick type base pairs and a loop of two residues.
(3) Hope u feel better xx” Bird told Channel 4’s political editor Michael Crick: “Natasha Bolter and I were in a consensual relationship between 18 September and 2 November, well after her admission to the list of approved candidates.
(4) The new Francis Crick Institute in London, now filling with 1,400 scientists, could be built and run for 10 years on that.
(5) The Watson-Crick H-bonded imino proton resonances were studied.
(6) The Watson-Crick alignment of the alkylG.T and alkylT.G mispairs may facilitate formation of these phosphodiester links, and this alignment rather than the strength of the base pairs and the extent of hydrogen bonding between them may be the crucial factor in the miscoding.
(7) The complex has one drug molecule intercalated between Watson--Crick base pairs of the nucleotide duplex.
(8) Recognition of the UACUAAC box thus relies, at least in part, on Watson-Crick base pairing with the yeast U2 analogue.
(9) A characteristic of Watson-Crick paired A X T and G X C bases is the pseudo 2-fold symmetry axis in the plane of the base pairs.
(10) The imino proton of T3 in the O6meG.T 12-mer and G3 in the O6meG.N 12-mer helix, which are associated with the modification site, resonate at unusually high field (8.5 to 9.0 ppm) compared to imino protons in Watson-Crick base pairs (12.5 to 14.5 ppm).
(11) We’d get recognised when we went out, and I developed a bad crick in my spine because I was staring at the pavement so much.
(12) The base pairing between piA and poly(U) in this system is probably of the Hoogsteen type (involving the 6-amino group and N7 of 3-isoadenosine) rather than of the Watson-Crick type.
(13) One of these models is a four-strand structure in which two duplexes of the Watson-Crick kind are specifically related by a twofold rotation axis and which has already been discussed in some detail.
(14) Nurse, too, believes the Crick is built on solid foundations.
(15) Molecular modeling shows that a stereochemically satisfactory structure can be build using C2'-endo sugars and a displacement of the Watson-Crick base-pair center from the helix axis of 2.5 A. Helical constraints of rise per residue (h = 3.26 A) and residues per turn (n = 12) were taken from fiber diffraction experiments of Arnott and Selsing (1974).
(16) The temperature variation of the imino proton NMR signals suggests that the hydrogen bonding in self-recognition is comparable in strength with that in a beta-DNA duplex, and NOE data are in accord with Watson-Crick rather than Hoogsteen base pairing.
(17) We describe NMR studies at superconducting fields which characterize aspects of the structure and stability of the 1 : 2 actinomycin-d-pG-C complex in solution as monitored at the Watson-Crick base pairs and backbone phosphate groups.
(18) From fibre diffraction data, models for triplex structures with poly(U).poly(A).poly(U) and poly(dT).poly(dA).poly(dT) have been proposed, in which the purine and one pyrimidine strand are Watson-Crick paired in an A' helix, and the other pyrimidine strand is Hoogsteen base-paired parallel to the purine strand along the major groove.
(19) The peptide forms a parallel, two-stranded coiled coil of alpha helices packed as in the "knobs-into-holes" model proposed by Crick in 1953.
(20) 7.09pm: On his blog, Newsnight's Michael Crick quotes an unnamed Liberal Democrat MP who told him he was amazed how much the Tories were willing to compromise.
Kink
Definition:
(n.) A twist or loop in a rope or thread, caused by a spontaneous doubling or winding upon itself; a close loop or curl; a doubling in a cord.
(n.) An unreasonable notion; a crotchet; a whim; a caprice.
(v. i.) To wind into a kink; to knot or twist spontaneously upon itself, as a rope or thread.
(n.) A fit of coughing; also, a convulsive fit of laughter.
Example Sentences:
(1) In seven patients surgical correction of kinking with stenosis of the extracranial part of the carotid artery was performed.
(2) Occasionally symptomatic kinking of the internal carotid artery will require correction.
(3) A simple and effective surgical procedure as a routine method for correction of carotid kinking is described.
(4) It was concluded that photodimerization of the dTpdT unit to give the cis-syn product causes little perturbation of the DNA whereas dimerization to give the trans-syn product causes much greater perturbation, possibly in the form of a kink or dislocation at the 5'-side of the dimer.
(5) There is little chance of kinking the graft, since its angle of attachment is ideal, and due to the anatomical configuration of the transverse sinus, there is more room for the graft and compression is unlikely.
(6) On the aortogram, stenosis of the left common carotid artery, kinking and aneurysm of the descending thoracic aorta were revealed.
(7) However, no reactivity is observed at the sites of the 40 degrees kinks described in the cocrystal structure (Steitz, 1990).
(8) However, there is enough evidence to warrant careful consideration of surgical correction in patients who have features of the carotid artery syndrome and kinking of the ICA as shown on angiography.
(9) The spin-echo technique with a short time to echo (TE = 40 msec) and a short time to recover (TR = 1000 msec) provided optimum imaging of tonsillar position, hydromyelia cavities, and cervicomedullary "kinking."
(10) Kinking, contractures, transverse splitting and disintegration were seen in muscle fibres from post mortem muscle.
(11) The former appears characteristic of circularly bent DNA and gives rise to a substantial retardation, the latter of bending across a knot or kink in the DNA chain associated with a relatively minor retardation relative to standards.
(12) The obstruction failed to resolve; careful longitudinal serotomy allowed the kinking in the bowel to be straightened and, at 1 year follow-up, there were no symptoms of recurrence.
(13) The most important contribution of this procedure is the decrease in manipulation of the ureter, resulting in minimal disturbance of the blood supply and in a straight course of the ureter without the risk of kinking or obstruction.
(14) Detection of venous backflow or obstruction, arterial stenosis, aneurysm formation, or graft kinking facilitated correction and thus salvage of the grafts.
(15) Proton and deuterium order parameters measured for the liquid crystalline phase of unsonicated lipid bilayer membranes are interpreted in terms of two motions: (i) chain reorientation and (ii) chain isomerization via kink diffusion.
(16) Twenty-three patients had slight stenosis, and bending and kinking were observed in 17.
(17) As we go along all these kinks will be ironed out.” Under Ghanaian law, farmers are only allowed to sell their beans to purchasing clerks who act as intermediaries between them and Cocobod.
(18) Failure to release this structure from the proximal ulna caused kinking and tethering of the nerve when transposition was attempted.
(19) During neo-pulmonary reconstruction, distal pulmonary orifice was shifted towards right to avoid kinking and compression on the coronary arteries.
(20) The large hyperchroism of the complex is consistent with loss of base stacking, as required by a kinked structure.