(n.) The creaking of a door, or a noise resembling it.
(n.) A painful, spasmodic affection of the muscles of some part of the body, as of the neck or back, rendering it difficult to move the part.
(n.) A small jackscrew.
Example Sentences:
(1) This suggests that (AGG)12 can form intra- and inter-molecular complexes by non-Watson-Crick, guanine:guanine base-pairing.
(2) It is demonstrated that this peculiar DNA fragment, under suitable conditions of concentration, salt and temperature, exclusively prefers to adopt a monomeric hairpin form with a stem of three Watson-Crick type base pairs and a loop of two residues.
(3) Hope u feel better xx” Bird told Channel 4’s political editor Michael Crick: “Natasha Bolter and I were in a consensual relationship between 18 September and 2 November, well after her admission to the list of approved candidates.
(4) The new Francis Crick Institute in London, now filling with 1,400 scientists, could be built and run for 10 years on that.
(5) The Watson-Crick H-bonded imino proton resonances were studied.
(6) The Watson-Crick alignment of the alkylG.T and alkylT.G mispairs may facilitate formation of these phosphodiester links, and this alignment rather than the strength of the base pairs and the extent of hydrogen bonding between them may be the crucial factor in the miscoding.
(7) The complex has one drug molecule intercalated between Watson--Crick base pairs of the nucleotide duplex.
(8) Recognition of the UACUAAC box thus relies, at least in part, on Watson-Crick base pairing with the yeast U2 analogue.
(9) A characteristic of Watson-Crick paired A X T and G X C bases is the pseudo 2-fold symmetry axis in the plane of the base pairs.
(10) The imino proton of T3 in the O6meG.T 12-mer and G3 in the O6meG.N 12-mer helix, which are associated with the modification site, resonate at unusually high field (8.5 to 9.0 ppm) compared to imino protons in Watson-Crick base pairs (12.5 to 14.5 ppm).
(11) We’d get recognised when we went out, and I developed a bad crick in my spine because I was staring at the pavement so much.
(12) The base pairing between piA and poly(U) in this system is probably of the Hoogsteen type (involving the 6-amino group and N7 of 3-isoadenosine) rather than of the Watson-Crick type.
(13) One of these models is a four-strand structure in which two duplexes of the Watson-Crick kind are specifically related by a twofold rotation axis and which has already been discussed in some detail.
(14) Nurse, too, believes the Crick is built on solid foundations.
(15) Molecular modeling shows that a stereochemically satisfactory structure can be build using C2'-endo sugars and a displacement of the Watson-Crick base-pair center from the helix axis of 2.5 A. Helical constraints of rise per residue (h = 3.26 A) and residues per turn (n = 12) were taken from fiber diffraction experiments of Arnott and Selsing (1974).
(16) The temperature variation of the imino proton NMR signals suggests that the hydrogen bonding in self-recognition is comparable in strength with that in a beta-DNA duplex, and NOE data are in accord with Watson-Crick rather than Hoogsteen base pairing.
(17) We describe NMR studies at superconducting fields which characterize aspects of the structure and stability of the 1 : 2 actinomycin-d-pG-C complex in solution as monitored at the Watson-Crick base pairs and backbone phosphate groups.
(18) From fibre diffraction data, models for triplex structures with poly(U).poly(A).poly(U) and poly(dT).poly(dA).poly(dT) have been proposed, in which the purine and one pyrimidine strand are Watson-Crick paired in an A' helix, and the other pyrimidine strand is Hoogsteen base-paired parallel to the purine strand along the major groove.
(19) The peptide forms a parallel, two-stranded coiled coil of alpha helices packed as in the "knobs-into-holes" model proposed by Crick in 1953.
(20) 7.09pm: On his blog, Newsnight's Michael Crick quotes an unnamed Liberal Democrat MP who told him he was amazed how much the Tories were willing to compromise.
Prick
Definition:
(v.) That which pricks, penetrates, or punctures; a sharp and slender thing; a pointed instrument; a goad; a spur, etc.; a point; a skewer.
(v.) The act of pricking, or the sensation of being pricked; a sharp, stinging pain; figuratively, remorse.
(v.) A mark made by a pointed instrument; a puncture; a point.
(v.) A point or mark on the dial, noting the hour.
(v.) The point on a target at which an archer aims; the mark; the pin.
(v.) A mark denoting degree; degree; pitch.
(v.) A mathematical point; -- regularly used in old English translations of Euclid.
(v.) The footprint of a hare.
(v.) A small roll; as, a prick of spun yarn; a prick of tobacco.
(n.) To pierce slightly with a sharp-pointed instrument or substance; to make a puncture in, or to make by puncturing; to drive a fine point into; as, to prick one with a pin, needle, etc.; to prick a card; to prick holes in paper.
(n.) To fix by the point; to attach or hang by puncturing; as, to prick a knife into a board.
(n.) To mark or denote by a puncture; to designate by pricking; to choose; to mark; -- sometimes with off.
(n.) To mark the outline of by puncturing; to trace or form by pricking; to mark by punctured dots; as, to prick a pattern for embroidery; to prick the notes of a musical composition.
(n.) To ride or guide with spurs; to spur; to goad; to incite; to urge on; -- sometimes with on, or off.
(n.) To affect with sharp pain; to sting, as with remorse.
(n.) To make sharp; to erect into a point; to raise, as something pointed; -- said especially of the ears of an animal, as a horse or dog; and usually followed by up; -- hence, to prick up the ears, to listen sharply; to have the attention and interest strongly engaged.
(n.) To render acid or pungent.
(n.) To dress; to prink; -- usually with up.
(n.) To run a middle seam through, as the cloth of a sail.
(n.) To trace on a chart, as a ship's course.
(n.) To drive a nail into (a horse's foot), so as to cause lameness.
(n.) To nick.
(v. i.) To be punctured; to suffer or feel a sharp pain, as by puncture; as, a sore finger pricks.
(v. i.) To spur onward; to ride on horseback.
(v. i.) To become sharp or acid; to turn sour, as wine.
(v. i.) To aim at a point or mark.
Example Sentences:
(1) These results have implications in utilizing codeine phosphate as a positive skin prick test control for allergy testing.
(2) The diagnosis of occupational allergy was based on history, skin prick tests and RAST to the pollen.
(3) Prick tests performed on 16 different condom brands showed that 4 brands caused positive reactions in 52-67% of patients.
(4) One hundred and forty-four had non-allergic and 69 allergic asthma verified retrospectively by positive skin prick test in 1988.
(5) The results of this investigation are clearly in contrast to earlier earlier reports, in that there was a very good correlation between prick test, RAST and case history.
(6) The prick tests, using both commercial allergens and specific extracts prepared from the most common types of coffee and their corresponding sacks, confirmed a sensitization in 21 workers (9.6%).
(7) There were statistically significant exposure-response relations between exposure and symptoms from eyes and upper airways, dry cough, positive skin prick test, and specific IgE and IgG antibodies.
(8) The effect of 4.4 mg azelastine administered orally on airway responsiveness, skin prick testing, daily peak expiratory flow rates and symptoms of asthma was compared with placebo in a 7 week double-blind, parallel group study of 24 patients with extrinsic asthma.
(9) Subjective pain ratings of mucosal pin-prick decreased a surprisingly small degree after application of both solutions.
(10) Having said that, though, the man is clearly a bit of a prick and one with a serial addiction to publicity."
(11) In allergologic out-patient departments of Dubrovnik, Split, Sibenik, Zadar, Pula and Rijeka, 300 patients with pollinosis have been tested by the application of the prick method of group allergens of grass, tree and weed pollen, particularly of Parietariae (pellitory) pollen.
(12) In comparison with conventional allergen preparations immunologically characterized allergens were tested by skin-prick-tests for reactions.
(13) Exclusion of asthmatics and taking into account smoking and skin prick test positivity yielded mostly similar results.
(14) The results of the Phadezym-RAST and IgE-Quick correlated very well (r = 0.96) and both in-vitro methods corresponded to the Skin-Prick-Test (greater than 90%).
(15) Throughout history there have been periods of wild exuberance followed by the pricking of bubbles.
(16) By skin prick testing comparable results were obtained with both extracts.
(17) In both groups of patients, there was a low incidence of the causes of post-cordotomy pain recurrence contralateral to the lesion, i.e., deafferentation pain, fading of analgesia, and pain above the levels up to which deep pin-prick analgesia had been obtained.
(18) In making a computerized cephalometric analysis, first the film should be traced, and the landmarks pricked and manually digitalized into an X-Y coordinate system.
(19) Sections of eggs, fixed 20 to 60 s following fertilization or pricking, show that the tubular cisternae have disappeared and the clusters of cisternae have opened to give rise to longer cisternae arranged in chains.
(20) Bronchial responsiveness to histamine and skin prick test reactions to airborne allergens were measured in a random population sample of 891 adults and 1293 schoolchildren.