(n.) The creaking of a door, or a noise resembling it.
(n.) A painful, spasmodic affection of the muscles of some part of the body, as of the neck or back, rendering it difficult to move the part.
(n.) A small jackscrew.
Example Sentences:
(1) This suggests that (AGG)12 can form intra- and inter-molecular complexes by non-Watson-Crick, guanine:guanine base-pairing.
(2) It is demonstrated that this peculiar DNA fragment, under suitable conditions of concentration, salt and temperature, exclusively prefers to adopt a monomeric hairpin form with a stem of three Watson-Crick type base pairs and a loop of two residues.
(3) Hope u feel better xx” Bird told Channel 4’s political editor Michael Crick: “Natasha Bolter and I were in a consensual relationship between 18 September and 2 November, well after her admission to the list of approved candidates.
(4) The new Francis Crick Institute in London, now filling with 1,400 scientists, could be built and run for 10 years on that.
(5) The Watson-Crick H-bonded imino proton resonances were studied.
(6) The Watson-Crick alignment of the alkylG.T and alkylT.G mispairs may facilitate formation of these phosphodiester links, and this alignment rather than the strength of the base pairs and the extent of hydrogen bonding between them may be the crucial factor in the miscoding.
(7) The complex has one drug molecule intercalated between Watson--Crick base pairs of the nucleotide duplex.
(8) Recognition of the UACUAAC box thus relies, at least in part, on Watson-Crick base pairing with the yeast U2 analogue.
(9) A characteristic of Watson-Crick paired A X T and G X C bases is the pseudo 2-fold symmetry axis in the plane of the base pairs.
(10) The imino proton of T3 in the O6meG.T 12-mer and G3 in the O6meG.N 12-mer helix, which are associated with the modification site, resonate at unusually high field (8.5 to 9.0 ppm) compared to imino protons in Watson-Crick base pairs (12.5 to 14.5 ppm).
(11) We’d get recognised when we went out, and I developed a bad crick in my spine because I was staring at the pavement so much.
(12) The base pairing between piA and poly(U) in this system is probably of the Hoogsteen type (involving the 6-amino group and N7 of 3-isoadenosine) rather than of the Watson-Crick type.
(13) One of these models is a four-strand structure in which two duplexes of the Watson-Crick kind are specifically related by a twofold rotation axis and which has already been discussed in some detail.
(14) Nurse, too, believes the Crick is built on solid foundations.
(15) Molecular modeling shows that a stereochemically satisfactory structure can be build using C2'-endo sugars and a displacement of the Watson-Crick base-pair center from the helix axis of 2.5 A. Helical constraints of rise per residue (h = 3.26 A) and residues per turn (n = 12) were taken from fiber diffraction experiments of Arnott and Selsing (1974).
(16) The temperature variation of the imino proton NMR signals suggests that the hydrogen bonding in self-recognition is comparable in strength with that in a beta-DNA duplex, and NOE data are in accord with Watson-Crick rather than Hoogsteen base pairing.
(17) We describe NMR studies at superconducting fields which characterize aspects of the structure and stability of the 1 : 2 actinomycin-d-pG-C complex in solution as monitored at the Watson-Crick base pairs and backbone phosphate groups.
(18) From fibre diffraction data, models for triplex structures with poly(U).poly(A).poly(U) and poly(dT).poly(dA).poly(dT) have been proposed, in which the purine and one pyrimidine strand are Watson-Crick paired in an A' helix, and the other pyrimidine strand is Hoogsteen base-paired parallel to the purine strand along the major groove.
(19) The peptide forms a parallel, two-stranded coiled coil of alpha helices packed as in the "knobs-into-holes" model proposed by Crick in 1953.
(20) 7.09pm: On his blog, Newsnight's Michael Crick quotes an unnamed Liberal Democrat MP who told him he was amazed how much the Tories were willing to compromise.
Spasm
Definition:
(v. t.) An involuntary and unnatural contraction of one or more muscles or muscular fibers.
(v. t.) A sudden, violent, and temporary effort or emotion; as, a spasm of repentance.
Example Sentences:
(1) The generally accepted hypothesis is a coronary spasm but a direct cardiotoxicity of 5-FU cannot be.
(2) Oculomotor paresis with cyclic spasms is a rare syndrome, usually noticeable at birth or developing during the first year of life.
(3) The ophthalmic headache's crisis is caused, in fact, by a spasm of convergence on an unknown exophory of which the amplitude of fusion is satisfying, and the presence of which can only be seen with test under screen.
(4) The present case indicates that the possibility of osseous spines impinging on the facial nerve should be considered in all cases of facial spasm.
(5) The coronary arteriography reveals a spasm in the normal left anterior descendens artery.
(6) Increasing awareness of disorders such as coronary arterial spasm, functional impairment of subendocardial blood flow and the possible role of variant patterns of anatomic distribution of the coronary arterial tree, will provide a better understanding of their significance as determining or contributing factors in patients with the anginal syndrome.
(7) Thus one may speculate that endothelin plays a role in the coronary spasm which has been shown in patients with angina pectoris.
(8) in 1937, the arterial spasm may have occurred at the time of cerebral embolism.
(9) Coronary spasm was provoked by ergonovine maleate in four of 12 patients in group A (33%) and in three patients in group B (18%).
(10) In 2 cases, sublingual nitroglycerin failed to completely relieve the spasm.
(11) Furthermore, an association of tiapride-corticoids was effective in treating post-anaesthetic spasm of the glottis.
(12) Case histories of two patients with hypertensive LES and normal peristalsis in the body of the esophagus are contrasted to that of a patient with a hypertensive LES and diffuse esophageal spasm.
(13) Whether they affect ureteral motility in vivo or whether they can counteract ureteral spasm associated with ureteral stones have not been established.
(14) Thrombotic occlusion, in association with varying degrees of plaque disruption and coronary artery spasm, represents the major cause of acute myocardial infarction (AMI).
(15) The patients with spasm on top of a fixed organic lesion underwent a successful aorto-coronary bypass graft together with resection of the pre- and sub-aortic nerve plexus.
(16) In vitro tests with isolated trachea or ileum of guinea pigs show that flupirtine possesses no or very weak antagonism against histamine-induced spasms.
(17) The spasms were inhibited by gallopamil (100 nM) and diltiazem (1 microM).
(18) Indeed this procedure is the only one which can act in a fitted manner on muscular spasms responsible of more than 60% of convergent squints.
(19) Such an exercise response should suggest significant fixed coronary stenosis in addition to coronary spasm.
(20) Evidence is provided for the concept of enlarged spasms (phenomenon of the spastic dominant) common to peptic ulcer.