(n.) The attribute or quality of being cruel; a disposition to give unnecessary pain or suffering to others; inhumanity; barbarity.
(n.) A cruel and barbarous deed; inhuman treatment; the act of willfully causing unnecessary pain.
Example Sentences:
(1) Solzhenitsyn was acknowledged as a "truth-teller" and a witness to the cruelties of Stalinism of unusual power and eloquence.
(2) Butler was convicted of grevious bodily harm and child cruelty, and sentenced to prison.
(3) So it was with cruelty – the same cruelty seen in the enactment of the Muslim travel ban and the gamble with the healthcare of 24 million people – that Trump signed an executive order to begin construction immediately .
(4) She believes her explorations – of their vanities, their blindnesses, their cruelties, of the brief moments in which they attain goodness, or glimpse a kind of realistic, unselfish love – to be of urgent importance.
(5) The FN has made political capital about cruelty to animals in the preparation of halal and kosher meat in the past, and its MEPs are preparing a resolution that would limit shale gas exploration, despite the party voting against a shale moratorium in the last parliament.
(6) In 2005, four years after Adam's body was found, two women and a man were convicted of child cruelty for torturing and threatening to kill an orphaned refugee who they claimed was a witch.
(7) Strong objections to certain features of this system have not only been raised by national and international societies for the prevention of cruelty to animals but also by ethologists.
(8) Finally, Sybil Burton gave in, claiming cruelty and that her husband was "in the constant company of another woman," which Newsweek called "the throwaway line of the decade".
(9) His mother, devoted and stoic, read aloud the sad, true stories of cruelty and passion between the wars contained in his father's briefs for the divorce court.
(10) The heads of the World Health Organisation, Unicef, the Office for the Co-ordination of Humanitarian Affairs, the World Food Programme and the UNHCR, the UN refugee agency, urged political leaders to use their influence to solve the crisis and criticised what they described as "an insufficient sense of urgency among the governments and parties that could put a stop to the cruelty and carnage in Syria".
(11) Why does the sight, or even the mere thought, of the obese excite such venom, disgust and outright cruelty?
(12) Those who doubted football's capacity for cruelty ought to have been on hand in Paris - much in the manner that Thierry Henry was for France .
(13) She served either as a director or council member of the Conservation Society, Soil Association, Animal Defence Society, Royal Society for the Prevention of Cruelty to Animals and Society for the Protection of Animals.
(14) They are not motivated by cruelty but by a powerful desire to push the frontiers of medical research and develop therapies for debilitating diseases.
(15) Labour now wants to own this mantle of macho, to keep the momentum of cruelty going in the name of responsibility, But lets get real.
(16) It predicts: "As these conflicts and crises grow ever more intense, and as the ruling elite continues with impunity to crush and to strip away the rights of citizens to freedom, to property, and to the pursuit of happiness, we see the powerless in our society – the vulnerable groups, the people who have been suppressed and monitored, who have suffered cruelty and even torture, and who have had no adequate avenues for their protests, no courts to hear their pleas -– becoming more militant and raising the possibility of a violent conflict of disastrous proportions.
(17) Jennie Gray was sentenced to 42 months in jail for child cruelty and for her part in the cover-up, while Butler was also handed a five-year sentence for child cruelty over a series of untreated injuries in the weeks and months before her death.
(18) Liberal and Labor have moved close together on cruelty to refugees to cutting funding to universities and on increasing coal exports, so I am not in the least bit surprised you’ve got this collusion,” she said.
(19) Would people bring their children to SeaWorld if they knew the cruelty behind the orca whale circus show?
(20) Recognition of unacceptable cruelty to animals in pasttimes such as bull-baiting, dates in Britain from the early 19th century.
Malice
Definition:
(n.) Enmity of heart; malevolence; ill will; a spirit delighting in harm or misfortune to another; a disposition to injure another; a malignant design of evil.
(n.) Any wicked or mischievous intention of the mind; a depraved inclination to mischief; an intention to vex, annoy, or injure another person, or to do a wrongful act without just cause or cause or excuse; a wanton disregard of the rights or safety of others; willfulness.
(v. t.) To regard with extreme ill will.
Example Sentences:
(1) After addition of triiodothyronine, malic enzyme mRNA accumulated with sigmoidal kinetics, approaching a new steady state at 36-48 h after adding hormone.
(2) In addition to detecting three major antigenic variants of malic enzyme within this group, both antisera readily reacted with Streptococcus faecalis malic enzyme.
(3) The oxidative enzymes of the pentose phosphate pathway, ATP-citrate lyase, 'malic' enzyme and fatty acid synthetase also decrease markedly.
(4) Hormone therapy also caused an increase in the rate of incorporation of [3H]leucine into soluble proteins and in malic enzyme activity.
(5) Moreover, the transcriptional rate, mRNA concentration and induction of malic enzyme were increased by triiodothyronine treatment at a similar rate in both the young and old rats, but the absolute increments were lower in the old animals.
(6) The TRH treatment suppressed mitochondrial cytochrome c reductase and glucose-6-phosphatase activities, whereas cyclo(His-Pro) reduced cytochrome c reductase and malic enzyme activities.
(7) Activities of glucose-6-phosphate dehydrogenase and malic dehydrogenase of the mycelial form were higher than those of the yeast form.
(8) These observations suggest that in the rat neostriatum there are some neurons especially able to catabolize pyruvate via cytosolic malic isoenzyme.
(9) Thus a long-lived event in thyroid hormone stimulation of malic enzyme synthesis occurred prior to transcription of a specific messenger RNA (mRNA), presumably malic enzyme mRNA.
(10) In the Ob 17 preadipocyte cell line, during adipose differentiation, T3 amplified the progressive expression of two enzymes of the lipogenic pathway, ATP-citrate lyase (ATP-CL) and malic enzyme (ME) as previously described for fatty acid synthase (FAS) and fatty acid synthesis, and in the same time-period of development.
(11) The nucleotide sequence of the mRNA for malic enzyme ((S)-malate NADP+ oxidoreductase (oxaloacetate-decarboxylating, EC 1.1.1.40) from rat liver was determined from three overlapping cDNA clones.
(12) The specific nuclear binding of triiodothyronine (T3) (NBT3) and the activity of malic enzyme (ME), glucose-6-phosphate-dehydrogenase (G6PD), and 6-phosphogluconate-dehydrogenase (6PGD) were studied in the human fibroblast cell (MRC-5).
(13) 2-Hydroxyisobutyric acid, ethyl-2-hydroxybutyrate, malic acid, 1-butanol, benzyl alcohol and L-leucine did not act as substrates for the enzymes.
(14) Malic enzyme and glucose-6-phosphate dehydrogenase were highly active in the adipose tissue of mammals but were inactive in the adipose tissue of birds.
(15) Distribution of kinase activity in centrifugal fractions of both liver and heart mitochondrial sonicates was parallel to that of the two inner membrane marker enzymes succinic dehydrogenase and cytochrome oxidase and quite different from that of the matrix enzyme malic dehydrogenase.
(16) Glucose-6-phosphate dehydrogenase, 6-phosphogluconate dehydrogenase and malic enzyme are enzymes involved in NADPH synthesis.
(17) The antigenic enzymes, the precipitates of which are only stained by specific staining, are: aldolase, malic enzyme, acid phosphatase, peroxydase and cholinesterase.
(18) The coupling enzymes, fumarase (fumarate to L-malate) and malic enzyme (L-malate to pyruvate and NADPH), are adsorbed to nitrocellulose prior to blotting.
(19) The latter region apparently includes the malic dehydrogenase-1 gene.
(20) Some reactions, such as malic enzyme and glutamate dehydrogenase, may be inhibited or deleted with little or no adverse effect on the calculated cell growth rate.