(n.) Anything that is very puzzling or difficult to explain.
Example Sentences:
(1) Although the most common pattern is for the right coronary artery to bifurcate at the crux giving the posterior descending (posterior interventricular) artery, a branch may arise before the crux, either as an aberrant acute marginal artery or as an early posterior descending artery, crossing the diaphragmatic surface of the right ventricle.
(2) Kafala sponsorship system At the crux of the debate over how Qatar and its Gulf neighbours treat migrant workers, human rights groups have long called for the kafala system that ties workers to their employers to be abolished.
(3) The crux of the trisection strategy is to restrict attention to the smallest block of ordered loci among which the new locus can fall and to divide this block into thirds for the next comparison.
(4) Bidirectional continuous turbulent Doppler signals were detected in the proximal portions of the dilated right and left coronary arteries, in the distal portions of the fistulas around the crux and in the right atrium.
(5) The crux is that the culling proposed by the government is very different to that in the earlier £50m RBCT.
(6) But the crux of the rift among Republicans is what to do about the roughly 11 million undocumented immigrants living in the US.
(7) That said, yeah, I think both public and private perception that big powerful game consoles are still somehow the crux or core focus of videogames will go away over the next few years, but even with the Vita TV and iPad Whatever and Steamboxes, I don't see these cannibalising enough of the existing console audience to actually make these things go away.
(8) These views provide improved visualization of the proximal branches of the left coronary artery, the region of the crux of the right coronary artery, and the left ventricle in the left anterior oblique projection; structures which in the conventional projections are often superimposed on one another or are foreshortened.
(9) The Mistake Creek Massacre, an indigenous painting at the crux of Australia’s culture wars.
(10) The septum which separated it from the main chamber was directed to the crux of the heart.
(11) I would say take it out, but it forms the crux of the call and is VERY funny.
(12) "We've won it," came the crux of Tenenbaum's translation.
(13) The crux of Muñoz Marín’s ridiculously illogical argument – one cannot achieve “political freedom” and be “deadset against colonialism” when one is not “demanding independence” or “asking for statehood” – illustrates how the island’s mostly white, male and affluent political class never had a real vision for Puerto Ricans or Puerto Rico , even from the outset of Muñoz Marín’s failed “commonwealth” experiment that he sold his fellow boricuas .
(14) In other words, the crux of this tale isn't Toronto city council's softness, it's Toronto voters' wildcard craziness.
(15) Cynics may ask: “If it is that simple, why can it not happen all the time?” That for me is the crux of the matter.
(16) The mass media campaign was important, but the party says the crux of its strategy was face-to-face meetings, conversation-by-conversation.
(17) The crux of the matter is whether the virus recovered from or detected in the cornea is 1) truly latent in cell populations that are nonneuronal; 2) resident in the cornea, replicating at a slow rate; or 3) newly arrived in the cornea following ganglionic reactivation.
(18) ", the memo said: "In typical fashion, while the government of Libya's public criticism has comprised pseudo-populist rhetoric against "the forces of Zionism", the crux of the matter is in fact about personal relations and politics."
(19) Because estimates of recombination are different in each set of data, the crux of the problem is to present scores that provide a close approximation to the true likelihood away from maximum likelihood (ML).
(20) Finally, the distribution of blood vessels within the retina formed a watershed pattern with its crux centered on the ridge of this horizontally oriented high-density zone.
Pith
Definition:
(n.) The soft spongy substance in the center of the stems of many plants and trees, especially those of the dicotyledonous or exogenous classes. It consists of cellular tissue.
(n.) The spongy interior substance of a feather.
(n.) The spinal cord; the marrow.
(n.) Hence: The which contains the strength of life; the vital or essential part; concentrated force; vigor; strength; importance; as, the speech lacked pith.
(v. t.) To destroy the central nervous system of (an animal, as a frog), as by passing a stout wire or needle up and down the vertebral canal.
Example Sentences:
(1) Finally, fosinopril had no effect on the pressor or chronotropic effects of norepinephrine (NE) or 1,1-dimethyl-4-phenylpiperinium (DMPP) or electrical stimulation of the sympathetic ganglia of pithed rats.
(2) Relatively weaker GUS activity was also detected in pith parenchyma.
(3) Both d- and l-amphetamine were also compared for their pressor and tachycardic activity in pithed rats.
(4) Intravenous administration of T-2 to pithed rats did not alter blood pressure or heart rate at a time when, in conscious rats, both blood pressure and heart rate were increased.
(5) Monoiodo-Ang II was found to be a potent, full agonist in in vivo bioassays and a more potent (2.5-fold) pressor agent than the native hormone Ang II in the pithed rat.
(6) APP 201-533 [3-amino-6-methyl-5-phenyl-2(1H)-pyridinone] was investigated in vivo in anesthetized and unanesthetized dogs and pithed open-chest cats and in vitro in guinea pig atria and papillary muscles, skinned muscle fibers from pig hearts, and rat myocardium.
(7) The effects of quinpirole, a specific dopamine DA2 receptor agonist, on autonomic nervous control of heart rate, were studied in normotensive pithed rats, by analysing its action on the tachycardia and bradycardia evoked by electrical stimulation of the cardioaccelerator (10 V; 1 ms; 0.5, 1, 3, 6 Hz) and vagus (10 V; 1 ms; 3, 6, 9 Hz) nerves respectively.
(8) Pith cells can shift from the C- to the C+ state by a process known as habituation.
(9) The pressor actions of ET3 and arginine vasopressin (AVP) were compared with one another in pithed rats in the presence of the calcium channel activator BAY K 8644 or the calcium channel antagonist nifedipine i.a.
(10) Both human endothelin 1 (ET1) and rat endothelin 3 (ET3) produced dose-dependent pressor effects in the pithed rat.
(11) Viprostol did not antagonize the tachycardia induced by stimulation of the discrete segments at C7-T1 (cardio-accelerator) of the spinal cord in pithed SHR, suggesting that viprostol did not activate the presynaptic alpha-adrenoceptors.
(12) In pithed rats, the vasopressor response to dihydroergotoxine was reduced competitively by yohimbine, and non-competitively by nifedipine, but not by prazosin or methysergide, showing that the vasoconstriction is mediated by alpha 2-adrenoceptors.
(13) The antagonistic effects of a new inositol phosphate derivative, D-myoinositol-1,2,6-trisphosphate (PP56), on pressor responses to preganglionic sympathetic nerve stimulation and exogenously administered phenylephrine or neuropeptide Y (NPY) were investigated in vivo in the pithed rat.
(14) We conclude that in contrast to the increase in diastolic pressure elicited by B-HT 920, calcium channels are not involved in the cirazoline-induced pressor responses in the pithed cat.
(15) Acute or chronic adrenalectomy did not alter the pressor responses and chronotropic effect of angiotensin in the pithed rat.
(16) Habituated cells derived from inducible pith cells give rise to normal plants whose leaf and pith tissues require cytokinin for growth in culture.
(17) The endovenous perfusion of the splenic material in acidified and alkalinized forms caused significant increases of the mean blood pressure in normal, vagotomized and pithed rats, showing that, in contradiction to previous reports, changes in pH did not affect its hypertensive activity.
(18) The dose-response curves of three alpha-agonists noradrenaline, St 587 and B-HT 933 in pithed rats were shifted rightwards by pretreatment (i.v.
(19) In pithed rats, only pindolol produced a definite fall of blood pressure.
(20) The bradycardia was reduced but not blocked by pre-treatment with guanethidine, yohimbine, propranolol or pithing.