(n.) The coloring principle of turmeric, or curcuma root, extracted as an orange yellow crystalline substance, C14H14O4, with a green fluorescence.
Example Sentences:
(1) Curcumin had a greater inhibitory effect on platelet-derived growth factor-stimulated proliferation than on serum-stimulated proliferation.
(2) Rosemary antioxidants (RA) and Curcumin (Cur) have weaker scavenging effects than Vc, but stronger than VE.
(3) Both sesamin and curcumin interfered with chain elongation of PUFAs.
(4) The graph also indicates the complexity of the curcumin degradation.
(5) Neither ascorbic acid nor curcumin inhibited quercetin-induced nuclear DNA damage, lipid peroxidation, or protein degradation.
(6) Both curcumin and ascorbyl palmitate have antioxidant activity and are potent inhibitors of 12-O-tetradecanoyl-phorbol-13-acetate-induced tumor promotion in mouse skin.
(7) Curcumin, a natural constituent of Curcuma longa (turmeric, CAS 458-37-7), has been studied for its induction of glutathione S-transferase activity in mice.
(8) The topical application of 10 mumol of curcumin together with 2 or 5 nmol of TPA inhibited the TPA-dependent stimulation of the incorporation of [3H]-thymidine into epidermal DNA by 49 or 29%, respectively, whereas lower doses of curcumin had little or no effect.
(9) Curcumin has proved nontoxic in a number of cell culture and whole animal studies.
(10) Oral and intraperitoneal doses of [3H]curcumin led to the faecal excretion of most of the radioactivity.
(11) The Australian team used the turmeric spice ingredient curcumin as a fluorescent tag that allowed beta-amyloid to show up in the retina.
(12) Benzo[a]pyrene-induced nuclear damage was not significantly inhibited by 4% curcumin under similar conditions.
(13) When intravenously injected or when added to the perfusate of the isolated liver, curcumin was actively transported into bile, against concentration gradients of several hundred times.
(14) Curcumin inhibited the release of myeloperoxidase, an azurophilic granule marker enzyme.
(15) The activity of hepatic cholesterol-7 alpha-hydroxylase, the rate-limiting enzyme of bile acid biosynthesis, was significantly elevated in curcumin (turmeric), capsaicin (red pepper), ginger and mustard treated animals.
(16) The effect of curcumin administration in reducing the serum levels of cholesterol and lipid peroxides was studied in ten healthy human volunteers, receiving 500 mg of curcumin per day for 7 days.
(17) Phenylbutazone and curcumin produced a better anti-inflammatory response than placebo.
(18) Our observations indicate that curcumin may alter the metabolic activation and detoxification of mutagens.
(19) The effects of ascorbic acid and curcumin on quercetin-induced DNA damage, lipid peroxidation protein degradation were investigated in a model system of isolated rat-liver nuclei under aerobic conditions and in the presence of equimolar concentrations of iron or copper.
(20) However, simultaneous stimulation of cholesterol synthesis by the spice principles--curcumin and capsaicin suggests that there may not be any significant contribution of stimulation of bile acid biosynthesis to the hypocholesterolemic action of these spices, and the latter action may solely be due to interference with exogenous cholesterol absorption.
Phenol
Definition:
(n.) A white or pinkish crystalline substance, C6H5OH, produced by the destructive distillation of many organic bodies, as wood, coal, etc., and obtained from the heavy oil from coal tar.
(n.) Any one of the series of hydroxyl derivatives of which phenol proper is the type.
Example Sentences:
(1) The teeth were embedded in phenolic rings with acrylic resin.
(2) The presence of the expected C19 neutral and C18 phenolic steroids was confirmed.
(3) The effect of mycobacterial phenolic glycolipids from Mycobacterium leprae, M. bovis BCG, and M. kansasii on in vitro proliferative responses by human blood mononuclear cells from healthy BCG vaccinees was investigated.
(4) The chemistry involved reaction rate constant measurements of MSF hydrolysis and for reactions with phenolic, amine, oxime, hydroxamic acid, phenyl N-hydroxycarbamate, and hydroxylamine compounds and cupric imidazole and bipyridyl complexes.
(5) In the liver, the major site of benzene metabolism, benzene is converted by a cytochrome P-450-mediated pathway to phenol, the major metabolite, and the secondary metabolites, hydroquinone and catechol.
(6) Except in the case of the phenolic metabolite, structures were confirmed by direct comparison of electron impact mass spectra and chromatographic behaviour with those of authentic samples.
(7) It may be concluded that phenolization of the sympathetic nervous system provides the same results as surgical sympathectomy but has the advantage of lower morbidity and shorter hospitalization (24 h vs 10 days).
(8) It was hypothesized that the observed activity variation of the paracetamol analogues was based on the relative abilities of these compounds to undergo H atom loss at the phenolic oxygen, and on the relative stabilities of the resulting free-radical species.
(9) Lipopolysaccharide content correlated significantly with drug uptake and sensitivity, and it appeared to determine the degree of penetration of the cell envelope by these chlorinated phenols.
(10) Liberation of the polysaccharides from the carrier by treatment with aqueous phenol resulted in loss of the serological activity.
(11) Here we report that phenol hydroxylation to hydroquinone is also catalyzed by human myeloperoxidase in the presence of a superoxide anion radical generating system, hypoxanthine and xanthine oxidase.
(12) The 2-substituted phenoxy-6-methoxy-8-aminoquinolines (4-6) were afforded by reduction of the corresponding 8-nitroquinolines (1-3) which were obtained by condensation of 2-chloro-6-methoxy-8-nitroquinoline and substituted phenols.
(13) This report reviews the treatment of pilonidal sinus by phenol injection in 54 patients.
(14) One group of rats was made immunocompetent towards P. aeruginosa by intraperitoneal injection of phenol-killed P. aeruginosa while a second group remained naive to this organism.
(15) These data indicate that the phenolic hydroxyl groups of xanthomegnin might contribute to its uncoupling action on the oxidative phosphorylation of mitochondria.
(16) The coupled dienone-phenol re-arrangement and keto-enol tautomerism of this quinone methide produce the observed 3,4-dihydroxybenzaldehyde.
(17) The phenol metabolites benzoquinone and 1,2,4-benzenetriol both activated the glutathione transferase in microsomes 2-fold independently of added NADPH.
(18) The isolation of plant enzymes is frequently hampered by the presence of phenolic compounds, pigments and mucilages.
(19) An enzyme (EC 2.8.2.1) that catalyses the transfer of sulphate from adenosine 3'-phosphate 5'-sulphatophosphate to phenols was purified approx.
(20) Physico-chemical parameters of membranes of skeletal muscles' sarcoplasmic reticulum in antioxidant insufficiency, which was modelled by excluding alpha-tocopherol from the animals ration, and after treatment with phenol antioxidant ionol were studied.