(1) Seminiferous epithelium in adult rats was studied by light and electron microscopy after 5 weeks of chronic administration of GnRH antagonist (Ac-D2 Nal 1, D4ClPhe 2, DTrp 3, DArg 6, DAla 10; GnRH code-103-289-10, National Institutes of Health, USA).
(2) The pattern of divergent transcription of the argEC BH cluster of genes previously demonstrated by the hybridization of RNA to the separated strand of a phi 80 darg transducing phage, is confirmed with the DNA of a set of different lambdadarg phages.
(3) In semi-thin preparations of rat testis treated with GnRH antagonist (Ac-D2Nal 1, D4ClPhe 2, DTrp 3, DArg 6, DAla 10; GnRH code- 103-289-10, National Institutes of Health, USA) for a period of 5 weeks, Leydig cells showed a reduction of 18% in the mean nuclear area as compared to the controls.
(4) Six adult ovariectomized rhesus macaques were given a gonadotropin-releasing hormone (GnRH) antagonist [Ac-beta-(2)DNAL,pFDPhe,DTrp,DArg]-GnRH, by intravenous infusion for 3 to 3.5 days to determine whether the positive feedback action of estradiol benzoate (E2B) on pituitary luteinizing hormone (LH) secretion could be inhibited by blockage of GnRH binding to pituitary gonadotropes.
(5) NPC 567 (DArg[Hyp3,DPhe7]-bradykinin), a B2 receptor antagonist, had no effect on bradykinin-induced 45Ca2+ efflux, but abolished prostaglandin synthesis.
(6) Both collagenases split bonds Gln-Gly and Leu-Gly in synthetic peptides DNP-Pro-Gln-Gly-Ile-Ala-Gly-Gln-DArg-OH and DNP-Pro-Leu-Gly-Ile-Ala-Gly-DArg-NH2, respectively.
(7) The effect of bradykinin was suppressed by the competitive kinin antagonist [DArg,Hyp3,Thi5,8,DPhe7]bradykinin.
(8) To examine the role of intrarenal kinins in deoxycorticosterone acetate-salt-treated rats, which have high renal kallikrein, Fab fragments of antibradykinin antibody or DArg[Hyp3Thi5,8DPhe7]bradykinin, a kinin antagonist, were used to block kinins.
(9) DArg[Hyp3,Gly6,Leu8]BK showed high affinity on Rb.J.V.
(10) Two new B1 receptor antagonists, [Hyp3,Thi5,DTic7,Oic8]desArg9-BK and DArg[Hyp3,Thi5,DTic7,Oic8]desArg9-BK were tested in vitro on the rabbit jugular vein and the guinea pig ileum (preparations containing B2 receptors) and on the rabbit aorta (preparation containing B1 receptors) for pharmacological characterization.
(11) In an amidolytic assay, the Ki values for the inhibition of human urinary kallikrein were 0.5, 0.3, and 2.5 microM for B4307 (DArg-Arg-Pro-Hyp-Gly-Thi-Ser-DPhe-Thi-Arg), B4308 (Lys-Lys-Arg-Hyp-Hyp-Gly-Thi-Ser-DPhe-Thi-Arg) and B3852 (Arg-Pro-Hyp-Gly-Phe-Ser-DPhe-Phe-Arg), respectively.
(12) Heteroduplex DNA mapping of these lumbdadarg and of the phi 80 darg isolated by B. Konrad indicates that the two kinds of phages carry the arg cluster in opposite orientations, a situation favorable for the isolation of argECBH DNA.
(13) DArg[Hyp3,DPhe7,Leu8]-BK showed pA2 values of 8.86 on Rb.J.V., but only 6.77 on G.P.I.
(14) In this study, we have used the potent, specific bradykinin antagonist DArg[Hyp3DPhe7] bradykinin (NPC 567) as a probe to examine the role of bradykinin in carrageenan-induced edema in the paws of rats.
(15) In a second group of rats pretreated with a B2 kinin receptor antagonist, [DArg Hyp3, Thi5,8 D Phe7]bradykinin, AA infusion raised urinary kinins identically as in untreated controls, but GFR and RPF responses were absent.
(16) [Arg1(Tos),Hyp3,Thi5,DTic7,Oic8]-BK and DArg[Hyp3,Thi5,DTic7,Oic8]-BK showed almost similar pA2 values on both Rb.J.V.
(17) The length (in kilobases, kb) of the segments, determined by electron microscopy and ararose gel electrophoresis is 4.2, 7.5, 8.4, 6.2, 6.9, and 6.4 kb for gamma darg13; 13.0, 7.5, 4.7, 6.2, 6.9, and 6.4 kb for gamma darg 14: and 5.3, 11.0, 4.7, 6.2, 6.9, and 6.4 kb for gamma darg23.
(18) The Ki values for B4307 (DArg-Arg-Pro-Hyp-Gly-Thi-Ser-DPhe-Thi-Arg), B4308 (Lys-Lys-Arg-Hyp-Hyp-Gly-Thi-Ser-DPhe-Thi-Arg), and B3852 (Arg-Pro-Hyp-Gly-Phe-Ser-DPhe-Phe-Arg) are 0.5, 0.3 and 2.5 microM, respectively.
(19) Two novel analogs of bradykinin (BK), [DAla7]-BK and DArg-BK, exhibited a dissociation of smooth muscle activities toward higher potency on the uterus than on the ileum, in spite of increased metabolic stability to pulmonary enzymatic breakdown in the rat blood pressure assay.
(20) The bradykinin analogs [desArg9,Leu8]BK and DArg[Hyp3,DPhe7]BK have been reported to have antagonist activity at the B1 and B2 bradykinin receptors in smooth muscle, respectively.
Dart
Definition:
(n.) A pointed missile weapon, intended to be thrown by the hand; a short lance; a javelin; hence, any sharp-pointed missile weapon, as an arrow.
(n.) Anything resembling a dart; anything that pierces or wounds like a dart.
(n.) A spear set as a prize in running.
(n.) A fish; the dace. See Dace.
(v. t.) To throw with a sudden effort or thrust, as a dart or other missile weapon; to hurl or launch.
(v. t.) To throw suddenly or rapidly; to send forth; to emit; to shoot; as, the sun darts forth his beams.
(v. i.) To fly or pass swiftly, as a dart.
(v. i.) To start and run with velocity; to shoot rapidly along; as, the deer darted from the thicket.
Example Sentences:
(1) Proceptivity (hop-darting) was facilitated by progesterone in females, but was never observed in males.
(2) Perisic darts in from the edge of the penalty area to get on the end of it and thumps a meaty header wide.
(3) ACTUALLY, IT GOT RATHER MORE THAN THAT World Darts, Sky Sports 1, 7pm – The PDC World Darts final, won by Adrian Lewis in a thrilling 7-5 win over Gary Anderson , averaged 884,000 viewers – and peaked with 1.27 million.
(4) Findley darts round him and slots him beneath the advancing Ricketts.
(5) After darting in from the left the forward fired a low shot past Martínez at the near post to crown a superb personal performance.
(6) Following 6 days of mental or physical practice by the experimental groups, the performance level on the dart-throwing task was again measured for all subjects.
(7) Playback partially reduced darting to control levels.
(8) She’s already being controlled.” Helping professionals recognise coercive control is a key reason that Monckton-Smith has created a new diagnostic system called Dart ( domestic abuse reference tool ): she hopes it will help elicit new information so that frontline workers can respond to the extreme danger that victims are in.
(9) Invited by Marcus Rashford to make a dart into the area Martial breezed past a bewildered Besic to cut the ball back from the byline and present Marouane Fellaini with a goal against his former club.
(10) The use of lightweight darts and a blowgun was found to be useful as a supplement to longer range dart projector systems since many animals could be approached at short range.
(11) They must have thought they had wrested control of this contest having started the second half with such urgency, the excellent Sergio Agüero – "a powerful tank," according to Mourinho – darting behind Gary Cahill to collect Samir Nasri's pass and thump a glorious finish high beyond Petr Cech at his near post.
(12) Soliciting behavior (hop-darting) was not enhanced by any treatment, suggesting that catecholamine activity has an inhibitory influence on the stop component of sexual behavior, but not on the whole copulatory pattern.
(13) But Marshall had also had to deny Tyler Walker twice and Michail Antonio once, with important stops, before finally having his resistance broken in the 86th minute, after Antonio had darted clear.
(14) She was shortlisted for a Forward prize at the age of 30 for her first collection, The Thing in the Gap-Stone Stile, took the TS Eliot prize with her second , a remarkable book-length poem about the river Dart, and is now, 15 years later, widely hailed as one of British poetry's finest, brightest voices.
(15) Chelsea could at least draw encouragement from Eden Hazard's winner, the team's leading scorer fed by Ashley Cole's pass to dart inside Jordi Amat and skim a shot goalwards, which Tremmel might have saved had Ashley Williams not dived across his eye-line.
(16) On Sunday, Leslee Dart, a publicist for Allen, 78, said: Mr Allen has read the article and found it untrue and disgraceful.
(17) The darting speck of fiery orange had gone, perhaps already on his way to another continent.
(18) If Labour were in fighting mood, there is no shortage of weak spots on the Conservative flank at which they could aim their darts.
(19) Protein occurs in the dart structure as an external sheath, as a lining to the tubular core and as a matrix component of the mineral phase.
(20) Small fish are darting in and out with as little apparent purpose as our day so far.