(1) Seminiferous epithelium in adult rats was studied by light and electron microscopy after 5 weeks of chronic administration of GnRH antagonist (Ac-D2 Nal 1, D4ClPhe 2, DTrp 3, DArg 6, DAla 10; GnRH code-103-289-10, National Institutes of Health, USA).
(2) The pattern of divergent transcription of the argEC BH cluster of genes previously demonstrated by the hybridization of RNA to the separated strand of a phi 80 darg transducing phage, is confirmed with the DNA of a set of different lambdadarg phages.
(3) In semi-thin preparations of rat testis treated with GnRH antagonist (Ac-D2Nal 1, D4ClPhe 2, DTrp 3, DArg 6, DAla 10; GnRH code- 103-289-10, National Institutes of Health, USA) for a period of 5 weeks, Leydig cells showed a reduction of 18% in the mean nuclear area as compared to the controls.
(4) Six adult ovariectomized rhesus macaques were given a gonadotropin-releasing hormone (GnRH) antagonist [Ac-beta-(2)DNAL,pFDPhe,DTrp,DArg]-GnRH, by intravenous infusion for 3 to 3.5 days to determine whether the positive feedback action of estradiol benzoate (E2B) on pituitary luteinizing hormone (LH) secretion could be inhibited by blockage of GnRH binding to pituitary gonadotropes.
(5) NPC 567 (DArg[Hyp3,DPhe7]-bradykinin), a B2 receptor antagonist, had no effect on bradykinin-induced 45Ca2+ efflux, but abolished prostaglandin synthesis.
(6) Both collagenases split bonds Gln-Gly and Leu-Gly in synthetic peptides DNP-Pro-Gln-Gly-Ile-Ala-Gly-Gln-DArg-OH and DNP-Pro-Leu-Gly-Ile-Ala-Gly-DArg-NH2, respectively.
(7) The effect of bradykinin was suppressed by the competitive kinin antagonist [DArg,Hyp3,Thi5,8,DPhe7]bradykinin.
(8) To examine the role of intrarenal kinins in deoxycorticosterone acetate-salt-treated rats, which have high renal kallikrein, Fab fragments of antibradykinin antibody or DArg[Hyp3Thi5,8DPhe7]bradykinin, a kinin antagonist, were used to block kinins.
(9) DArg[Hyp3,Gly6,Leu8]BK showed high affinity on Rb.J.V.
(10) Two new B1 receptor antagonists, [Hyp3,Thi5,DTic7,Oic8]desArg9-BK and DArg[Hyp3,Thi5,DTic7,Oic8]desArg9-BK were tested in vitro on the rabbit jugular vein and the guinea pig ileum (preparations containing B2 receptors) and on the rabbit aorta (preparation containing B1 receptors) for pharmacological characterization.
(11) In an amidolytic assay, the Ki values for the inhibition of human urinary kallikrein were 0.5, 0.3, and 2.5 microM for B4307 (DArg-Arg-Pro-Hyp-Gly-Thi-Ser-DPhe-Thi-Arg), B4308 (Lys-Lys-Arg-Hyp-Hyp-Gly-Thi-Ser-DPhe-Thi-Arg) and B3852 (Arg-Pro-Hyp-Gly-Phe-Ser-DPhe-Phe-Arg), respectively.
(12) Heteroduplex DNA mapping of these lumbdadarg and of the phi 80 darg isolated by B. Konrad indicates that the two kinds of phages carry the arg cluster in opposite orientations, a situation favorable for the isolation of argECBH DNA.
(13) DArg[Hyp3,DPhe7,Leu8]-BK showed pA2 values of 8.86 on Rb.J.V., but only 6.77 on G.P.I.
(14) In this study, we have used the potent, specific bradykinin antagonist DArg[Hyp3DPhe7] bradykinin (NPC 567) as a probe to examine the role of bradykinin in carrageenan-induced edema in the paws of rats.
(15) In a second group of rats pretreated with a B2 kinin receptor antagonist, [DArg Hyp3, Thi5,8 D Phe7]bradykinin, AA infusion raised urinary kinins identically as in untreated controls, but GFR and RPF responses were absent.
(16) [Arg1(Tos),Hyp3,Thi5,DTic7,Oic8]-BK and DArg[Hyp3,Thi5,DTic7,Oic8]-BK showed almost similar pA2 values on both Rb.J.V.
(17) The length (in kilobases, kb) of the segments, determined by electron microscopy and ararose gel electrophoresis is 4.2, 7.5, 8.4, 6.2, 6.9, and 6.4 kb for gamma darg13; 13.0, 7.5, 4.7, 6.2, 6.9, and 6.4 kb for gamma darg 14: and 5.3, 11.0, 4.7, 6.2, 6.9, and 6.4 kb for gamma darg23.
(18) The Ki values for B4307 (DArg-Arg-Pro-Hyp-Gly-Thi-Ser-DPhe-Thi-Arg), B4308 (Lys-Lys-Arg-Hyp-Hyp-Gly-Thi-Ser-DPhe-Thi-Arg), and B3852 (Arg-Pro-Hyp-Gly-Phe-Ser-DPhe-Phe-Arg) are 0.5, 0.3 and 2.5 microM, respectively.
(19) Two novel analogs of bradykinin (BK), [DAla7]-BK and DArg-BK, exhibited a dissociation of smooth muscle activities toward higher potency on the uterus than on the ileum, in spite of increased metabolic stability to pulmonary enzymatic breakdown in the rat blood pressure assay.
(20) The bradykinin analogs [desArg9,Leu8]BK and DArg[Hyp3,DPhe7]BK have been reported to have antagonist activity at the B1 and B2 bradykinin receptors in smooth muscle, respectively.
Drag
Definition:
(n.) A confection; a comfit; a drug.
(v. t.) To draw slowly or heavily onward; to pull along the ground by main force; to haul; to trail; -- applied to drawing heavy or resisting bodies or those inapt for drawing, with labor, along the ground or other surface; as, to drag stone or timber; to drag a net in fishing.
(v. t.) To break, as land, by drawing a drag or harrow over it; to harrow; to draw a drag along the bottom of, as a stream or other water; hence, to search, as by means of a drag.
(v. t.) To draw along, as something burdensome; hence, to pass in pain or with difficulty.
(v. i.) To be drawn along, as a rope or dress, on the ground; to trail; to be moved onward along the ground, or along the bottom of the sea, as an anchor that does not hold.
(v. i.) To move onward heavily, laboriously, or slowly; to advance with weary effort; to go on lingeringly.
(v. i.) To serve as a clog or hindrance; to hold back.
(v. i.) To fish with a dragnet.
(v. t.) The act of dragging; anything which is dragged.
(v. t.) A net, or an apparatus, to be drawn along the bottom under water, as in fishing, searching for drowned persons, etc.
(v. t.) A kind of sledge for conveying heavy bodies; also, a kind of low car or handcart; as, a stone drag.
(v. t.) A heavy coach with seats on top; also, a heavy carriage.
(v. t.) A heavy harrow, for breaking up ground.
(v. t.) Anything towed in the water to retard a ship's progress, or to keep her head up to the wind; esp., a canvas bag with a hooped mouth, so used. See Drag sail (below).
(v. t.) Also, a skid or shoe, for retarding the motion of a carriage wheel.
(v. t.) Hence, anything that retards; a clog; an obstacle to progress or enjoyment.
(v. t.) Motion affected with slowness and difficulty, as if clogged.
(v. t.) The bottom part of a flask or mold, the upper part being the cope.
(v. t.) A steel instrument for completing the dressing of soft stone.
(v. t.) The difference between the speed of a screw steamer under sail and that of the screw when the ship outruns the screw; or between the propulsive effects of the different floats of a paddle wheel. See Citation under Drag, v. i., 3.
Example Sentences:
(1) Northern Ireland will not be dragged back by terrorists who have nothing but misery to offer."
(2) Considerate touches includes the free use of cruiser bicycles (the best method of tackling the Palm Springs main drag), home-baked cookies … and if you'd like to get married, ask the manager: he's a minister.
(3) In Belfast, the old quarrels just look likely to drag on in their old familiar way.
(4) Two officers who witnessed the shooting of unarmed 43-year-old Samuel DuBose in Cincinnati will not face criminal charges, despite seemingly corroborating a false claim that DuBose’s vehicle dragged officer Ray Tensing before he was fatally shot.
(5) Finally, it examines Brancheau's death, which played out in front of a crowd, many of whom did not fully understand what was going on as the experienced trainer was dragged under water and flung around the tank.
(6) The longer the problem drags on, the less likely it is we get off lightly," he told the paper.
(7) "Those shows are genuinely moving us forward as an industry, they are dragging the rest of us behind," he says.
(8) Facebook Twitter Pinterest Neighbor Olga Ennis: ‘I watched them drag his body out of the house.
(9) I’m staying in a mobile home called a njalla , designed by artist and architect Joar Nango, which sits on wooden skis that allow you to drag it to a spot of your choosing.
(10) People were holding on to him, trying to pull themselves up by his belt, but only succeeded in dragging him into the water.
(11) The poor trade data indicate that net trade was an appreciable drag on GDP growth in the third quarter and was a major factor why expansion did not come in as high as 1.0% quarter-on-quarter as had seemed possible at one point.
(12) In PT (a) large extracellular markers are dragged by water flow indicating extracellular solute-water interaction, (b) transepithelial Pos is much higher than transcellular Pos.
(13) Consider the open joke that was the repeated European bank stress tests ; the foot-dragging of the central bankers to quell financial panic; the IMF report last week showing that even if Greece took the troika’s medicine it would still be lumbered with “unsustainable” debt .
(14) Tractional water resistance (drag, D, N) was also measured in the same range of speeds.
(15) If you stand on the main pedestrian drag, Ferhadija, and look east, you could be in Istanbul or Cairo.
(16) It would be a mistake to rush it.” But, while revealing disappointing trading figures for the Christmas period and a gloomy outlook for 2017 , Wolfson said he did not think Brexit jitters were stopping people from shopping: “It is more the fact that incomes are likely to be squeezed.” Next's gloomy 2017 forecast drags down fashion retail shares Read more Wolfson was one of a handful of senior business leaders to openly back Brexit but has said in the past that the referendum vote was about UK independence, not isolation, and the country should be aiming for “an open, global-facing economy”.
(17) The brothers said they were pleased that after “a great deal of dragging of their heels” the Mail and Hopkins had accepted the allegations were false.
(18) With the cultures of mycoplasmas obtained from the eyes of human patients suffering from sympathetic ophthalmia, it was possible to produce the same symptoms in chickens as were described by the author in 1950 in sympathizing and sympathized human eyes, namely: torpid uveitis and papillitis, which dragged on for months, and affected not only the inoculated right eye, but also, after 3 weeks and more, the untouched left eye.
(19) Interactions among the important constituents of the fibrocartilage matrix cause meniscal tissue to behave as a fiber-reinforced, porous, permeable composite material similar to articular cartilage, in which frictional drag caused by fluid flow governs its response to dynamic loading.
(20) This enabled the section commander to drag away the fallen soldier, who was dazed but unharmed.