(v. t.) To blot out; to erase; to expunge; to dele; to omit.
Example Sentences:
(1) Moreover, homozygous deletion of the FMS gene may be an important event in the genesis of the MDS variant 5q- syndrome.
(2) None of the 4NQO- or 4HAQO-induced mutants is a multilocus deletion mutant.
(3) In strains completely deleted for galR, the gene which encodes the Gal repressor, the operon is derepressed by only 10-fold without an inducer.
(4) Delta roc, which extends from base pairs 41883 to 43825, overlaps the nin5 deletion, which extend from base pairs 40501 to 43306.
(5) The deletions and substitutions appear to occur in separate molecules.
(6) By external deletion, we have identified RXE composed of 205 nucleotides.
(7) A 6.4 kilobase C4B-5'-specific Taq I fragment usually provided a reliable guide to the presence of a C4A deletion but unusually in one instance this fragment was found to be a marker of a functioning C4A gene.
(8) Three distinct antigenic regions of bovine somatotropin (bST) were identified on the basis of the ability of a set of monoclonal antibodies to bind to proteolytic fragments and deletion variants of recombinant bST (rbST) in Western blot analyses.
(9) Analysis of glutamate dehydrogenase (GDH) expression by enzyme assay and immunoblots, as well as Northern and dot blots of poly (A)+ RNA, in the deletion strains indicates that there are two upstream regulatory sequences that control the level of gene expression.
(10) Analysis of genetic markers associated with the deleted haplotypes pointed to the independent origin of similar deletions and the involvement of intergenic sequences in the mispairing-recombination process.
(11) Cells transfected with either the first or second construct and selected for the TK+ phenotype were then tested for TK induction after superinfection with HSV-1(F) delta 305, containing a deletion in the coding sequences of the TK gene, and viruses containing, in addition, a ts lesion in the alpha 4 regulatory protein (ts502 delta 305) or in the beta 8 major DNA-binding protein (tsHA1 delta 305).
(12) No 7 beta-hydroxysteroid dehydrogenase activity and only a trace of 7 alpha-hydroxysteroid dehydrogenase activity could be demonstrated when bile acid was deleted from the growth medium.
(13) All four human MBP variants were identical except for the insertion of deletion of two peptide fragments corresponding to those encoded by exons 2 and 5 of the MBP gene.
(14) Molecular analysis of HPRT- mutant DNAs showed a high frequency (69%) of clones with partial or full deletions of the hprt gene among radiation-induced mutants compared with spontaneous mutants (31%).
(15) Reciprocal translocations involving the short arm of acrocentric chromosomes can segregate to produce partial duplications without associated deletions.
(16) Considering those portions of the molecule that can be deleted without a loss of catalytic activity, one is left with a catalytic center of approximately 130 nucleotides that is solely responsible for the molecule's activity.
(17) Twenty-nine deletion breakpoints were mapped in 220 kb of the DXS164 locus relative to potential exons of the Duchenne and Becker muscular dystrophy gene.
(18) Then these two repeats were separated and deleted systematically to obtain various deletions.
(19) Although T cell tolerance to self antigens is primarily a reflection of clonal deletion in the thymus, recent evidence suggests that mature T cells are subject to negative regulation in the post-thymic environment: Extrathymic tolerance is the result of clonal anergy in some studies and T cell deletion in others.
(20) We report two cases of leiomyomas of the uterus with a deletion of the long arm of chromosome 13.
Unlink
Definition:
(v. t.) To separate or undo, as links; to uncoil; to unfasten.
Example Sentences:
(1) A cluster of unlinked genes encoding gluconeogenic enzymes in the mouse is characterized by the failure of normal hormone-inducible expression in animals homozygous for one of several overlapping deletions mapping on chromosome 7 near the albino locus.
(2) Four of the mutants had no effect on chylous ascites, but two mutants linked with ragged, and one unlinked, showed a complex situation involving enhancement, inhibition, epistacy and other interactions.
(3) At least two unlinked mutations were associated with such phenotypes.
(4) Strains with derepressed levels of the isoleucine and valine biosynthetic enzymes owing to linked or unlinked genetic lesions were found to exhibit ilv messenger RNA levels from 1.5- to 4-fold higher than did their isogenic parents.
(5) Several overlapping chromosomal deletions spanning the albino locus in the mouse cause perinatal lethality when homozygous and a block in the transcriptional induction of various unlinked hepatocyte-specific genes.
(6) The phenotypic expression of resistance at the fpaA locus can be suppressed by mutation of the str locus from str-s to str-r, whereas that at an unlinked fpa locus cannot.
(7) This inference is supported by the observation that a significant interaction (i.e., epistasis) was detected between the QTL(s) in the conserved region and an unlinked RFLP marker locus in both species.
(8) b) Locus TSM1 appears to be weakly linked to the locus PAR1 and to the loci RIB1 and RIB3 but unlinked to the locus OLI1.
(9) The three electrophoretic variants of phosphoglucomutase in Saccharomyces cerevisiae breeding stocks are produced by two unlinked genes, pgm-1 and pgm-2; pgm-1 contains two known alleles, pgm-1a and pgm-1b, each of which specifies a minor phosphoglucomutase component, and pgm-2 specifies the major phosphoglucomutase component.
(10) The "preferred" model specifying interaction between two major unlinked autosomal loci was confirmed indirectly by further breeding tests.
(11) The enzyme is an aggregate consisting of two protein components, coded for by the unlinked genes cpaI and cpaII.
(12) The second site is on chromosome III, unlinked to the centromere and distal to the mating type locus.
(13) Since in this study all unlinked genes segregated independently, this is direct evidence that MCF viruses participate in the induction of erythroleukemia.
(14) The segregation data indicate that the AKR mouse contains two unlinked, autosomal, chromosomal loci, either of which suffices to induce detectable levels of infectious virus in Fv-1(n) progeny by 6 wk of age.
(15) Additionally, we examined the combined data for evidence that a third, as yet unlinked locus exists.
(16) It is known that glnR5, a regulatory mutation unlinked to glnS, causes overproduction of glutaminyl-tRNA synthetase.
(17) relA and spoT are designations for two unlinked Escherichia coli genes whose products function in the synthesis and degradation of guanosine 3',5'-bispyrophosphate during the stringent regulatory response to amino acid deprivation.
(18) Allosuppressor (sal) mutations enhance the efficiency of the yeast ochre suppressor SUQ5 and define five unlinked loci, SAL1-SAL5.
(20) These data demonstrate that two unlinked transforming regions of human cytomegalovirus can cooperate to produce an aggressive tumorigenic phenotype.