(a.) Hurtful; noxious; destructive; pernicious; as, a deleterious plant or quality; a deleterious example.
Example Sentences:
(1) There was however no difference in the cross-sectional studies and no significant deleterious effect detected of tobacco use on forearm bone mineral content.
(2) A functional impairment of the amino acid transport systems at the level of the blood-brain barrier seems to play a crucial role in causing deleterious modifications of the synaptic neurotransmission in the central nervous system.
(3) Ecological risk assessments are used by the US Environmental Protection Agency (US EPA) and other governmental agencies to assist in determining the probability and magnitude of deleterious effects of hazardous chemicals on plants and animals.
(4) The average IEMG of the muscles in the relaxation phase of contraction remained unaltered by fatigue, while a marked deleterious change in the relaxation-time variables (p less than 0.001) occurred concomitantly.
(5) The results demonstrate that the addition of pulsatile flow to coronary perfusion minimized the deleterious effects of prolonged ventricular fibrillation on myocardial performance.
(6) He concludes that steroid contraceptives always have a deleterious effect on glucose tolerance, although not usually to the point of causing diabetes.
(7) While measles virus caused extensive damage to nervous tissue, the SSPE strains, in general, exerted a less deleterious effect.
(8) It is concluded that intestinal bypass in rats has a more deleterious effect than resection, and this seems to be more pronounced when the excluded segment is anastomosed to the colon.
(9) The homdr mutation is unstable and probably deleterious to the cell.
(10) The biological effects mediate by cachectin may be beneficial or deleterious to the body, depending on the quantity produced, duration of cell exposure and further biochemical mediators in the environment of the target cells.
(11) Although many studies report deleterious effects of inbreeding on prereproductive mortality (death before age 20 years), such effects are usually measured in terms of genetic load, a concept much debated in the literature.
(12) Moreover, the mechanical denudation technique did not deleteriously affect smooth muscle because vasoconstrictor and vasodilator responses to nonendothelial-dependent drugs were the same before and after denudation.
(13) University of Wisconsin solution can extend hypothermic cardiac preservation and has no deleterious effects on long-term myocardial function (up to 45 days).
(14) Phospholipase A2, which is known to be activated in ischemia, destroys the microstructure of myocardial cells, seems deleterious to oxygen transport to cytochrome a,a3.
(15) A more objective consideration relates to the observed late, progressive deleterious influences of hyperfiltration imposed upon the reduced population of surviving nephrons (3); would this process been exaggerated by improved perfusion?
(16) Sex hormone deficiency, as well as chronic illness, malnutrition, and childhood immobilization, has deleterious effects on growth and modeling, ultimately reducing peak bone mass and setting the stage for osteoporosis in later life.
(17) Myocardial transformation, along with its energy economizing effect, failed to compensate for unfavorable energetic consequences of structural dilatation and therefore the reduced ventricular efficiency is assumed to be another deleterious factor in the dilated failing heart.
(18) We conclude that storage at 22 degrees C had deleterious effects on the GP Ib content of platelets.
(19) All of these alleles have apparently resulted from gene conversion events that have transferred deleterious mutations from the CYP21A pseudogene to CYP21B.
(20) Within science, there are forces that weaken genuine scientific discussion, and these need at least to be explicated so that their deleterious effects can be minimized.
Pernicious
Definition:
(a.) Having the quality of injuring or killing; destructive; very mischievous; baleful; malicious; wicked.
(a.) Quick; swift (to burn).
Example Sentences:
(1) To investigate the possibility that an abnormality of gastric emptying exists in duodenal ulcer and to determine if such an abnormality persists after ulcer healing, scintigraphic gastric emptying measurements were undertaken in 16 duodenal ulcer patients before, during, and after therapy with cimetidine; in 12 patients with pernicious anemia, and in 12 control subjects.
(2) Urinary excretion of (60)Co radioactivity in pernicious anemia patients after oral administration of (60)Co-vitamin B(12) bound to freshly prepared (125)I-labeled IF was similar to that obtained with noniodinated intrinsic factor.
(3) Antibodies to parietal cells were found in 5 cases and 4 patients with pernicious anemia were detected.
(4) Reticulocytes of patients with pernicious anaemia on treatment and with haemolytic anaemia were shown to have higher folate levels than their corresponding mature cells.
(5) Immunofluorescence tests on 94 human sera reacting with rat gastric parietal cells revealed that 41 (44%) of the sera contained antibody to a rat parietal cell antigen that was distinct from the pernicious anaemia autoantigen.
(6) In pernicious anaemia the amount of enzyme is reduced and on this hypothesis the regulatory function impaired.
(7) Six patients without nervous system involvement had normal EEGs, 10 patients with spinal cord or peripheral nervous system involvement had normal or minimally abnormal EEGs, 17 of 19 patients with evidence of mental dysfunction had abnormal EEGs with the most consistent finding being an excess of theta slowing, and 19 patients with pernicious anemia and other neurologic diseases showed EEG findings reflecting the complicating disease process.
(8) This article details the pernicious odontostomatological effects provoked by antitumorous and immunosuppressive medication.
(9) This week, the resilience of Italy’s most pernicious problem – the mafia – was exposed once again when it was announced that Corleone’s town council was being dissolved by the order of Rome because it had been infiltrated by organised crime.
(10) Thus the Type A pattern of gastritis (autoimmune) seen in patients with pernicious anaemia is only rarely associated with Campylobacter like organisms.
(11) Thus, the processing of progastrin adjacent to the active site of gastrin is more restrictively controlled than N-terminal processing during G-cell hypersecretion associated with pernicious anemia.
(12) The early improvement in marrow morphology in patients with pernicious anaemia was greater with 1000 mug than with 5 mug doses of cyanocobalamin.
(13) They were found to have pernicious anemia (PA) and normal adrenal functions.
(14) The EEG was also a good indicator for detecting and confirming other intracranial disease processes unrelated to pernicious anemia.
(15) The endocrine tumours corresponded to the gastric carcinoids found in patients with long-lasting hypergastrinaemia due to pernicious anaemia or with a gastrinoma as part of the MEN I syndrome.
(16) Two vitiligo patients were hypergastrinaemic suggesting latent pernicious anaemia.
(17) 27 patients with pernicious anaemia, followed for a long period, were consecutively treated with three different vitamin B12 preparations, while during intervening period no therapy was given until signs of B12 deficiency developed.
(18) Sixteen control subjects, 13 patients with pernicious anaemia, and four who had had total gastrectomy were studied.
(19) And so while it’s particularly pernicious that some parents pay for months, sometimes years, of tutoring to get their child through an exam that they might well otherwise fail, I know it’s because they are desperate to secure for their child any extra benefit going in a country that is becoming ever more unequal.
(20) This policy, which prevents many travellers and overseas residents from benefitting from one of the most effective prophylactic treatments on the market today, thereby indirectly causing a number of pernicious cases of malaria, is based on the unfounded, unproved premise that wide use of this drug would foster the development of méfloquine-resistance or on side-effects, which are in fact rarely of any consequence and always curable.