(n.) The state of being depraved or corrupted; a vitiated state of moral character; general badness of character; wickedness of mind or heart; absence of religious feeling and principle.
Example Sentences:
(1) For here we see the depravity to which man can sink, the barbarity that unfolds when we begin to see our fellow human beings as somehow less than us, less worthy of dignity and life; we see how evil can, for a moment in time, triumph when good people do nothing."
(2) The comments emerged in an article about last year’s Manchester Pride event, which was described in the Christian Soldiers newsletter as an “annual parade of depravity”.
(3) It’s a sign there is an utter ruthlessness and depravity about this movement which is hideous and sickening and deplorable.
(4) The charges range from second-degree assault, a misdemeanor, to second-degree “depraved-heart” murder.
(5) People have, of course, always committed depraved and evil acts, but simply to say “It has always happened” does not explain what is distinctive about contemporary terrorism.
(6) Shortly before 9pm on Wednesday, her voice cracking with emotion, the prime minister confirmed that what she called the “sick and depraved” attack had been carried out by a single assailant.
(7) The fighting has often slid into horror and depravity over the past 22 months.
(8) It is impossible to fully fathom the depravity and horror inflicted on innocent people by Nazi terror.” Trump later pledged in the statement “to do everything in my power throughout my presidency, and my life, to ensure that the forces of evil never again defeat the powers of good”.
(9) A hymn to the depravity of Edinburgh that balances the noble pursuance of art.
(10) "[Eady] in effect ruled that it is perfectly acceptable for the multimillionaire head of a multibillion sport that is followed by countless young people to pay five women £2,500 to take part in acts of unimaginable sexual depravity with him," he said.
(11) I used to be so scared when going out in the deserted fields in the dark, because I could be attacked any time by depraved criminals,” she said.
(12) The film could be said to mark the moment when the favela – previously a byword for criminality, sickness and moral depravity – started to become “chic”.
(13) After nearly a decade of supporting roles in mostly decent movies – you could also add to the list Up In The Air, Paul, Hancock, and State Of Play – Bateman has finally worked his way up to leading-man status – albeit as a straight-seeming guy who gets away with improbable and morally depraved acts.
(14) From the depraved dregs of humanity; the glorious blossoming of hope, a tangible act of togetherness; the salvation of pop.
(15) During this time 101 patients died (23.2%), with whom severeness of disease as well as the extent of social depravation could be identified as factors influencing mortality.
(16) "This is yet another example of the depraved behaviour of the Syrian regime, and why it must go.
(17) In contrast to premeditated homicide, a first-degree charge, depraved heart murder alleges the suspect actions were predicated by recklessness – and not caring about that recklessness – rather than intent.
(18) Bateman always comes across as the sanest, smartest, straightest guy in the movie even though his characters regularly commit acts of either moral depravity or wild improbability, or both.
(19) If the shooting down of the aeroplane was wild, reckless and tragic then the behaviour of the rebels in the aftermath has been depraved.
(20) As we’ve seen so tragically – from Brussels to Istanbul to Iraq, where Isil slaughtered children watching soccer – these depraved terrorists still have the ability to inflict horrific violence on the innocent, to the revulsion of the entire world,” he said.
Malice
Definition:
(n.) Enmity of heart; malevolence; ill will; a spirit delighting in harm or misfortune to another; a disposition to injure another; a malignant design of evil.
(n.) Any wicked or mischievous intention of the mind; a depraved inclination to mischief; an intention to vex, annoy, or injure another person, or to do a wrongful act without just cause or cause or excuse; a wanton disregard of the rights or safety of others; willfulness.
(v. t.) To regard with extreme ill will.
Example Sentences:
(1) After addition of triiodothyronine, malic enzyme mRNA accumulated with sigmoidal kinetics, approaching a new steady state at 36-48 h after adding hormone.
(2) In addition to detecting three major antigenic variants of malic enzyme within this group, both antisera readily reacted with Streptococcus faecalis malic enzyme.
(3) The oxidative enzymes of the pentose phosphate pathway, ATP-citrate lyase, 'malic' enzyme and fatty acid synthetase also decrease markedly.
(4) Hormone therapy also caused an increase in the rate of incorporation of [3H]leucine into soluble proteins and in malic enzyme activity.
(5) Moreover, the transcriptional rate, mRNA concentration and induction of malic enzyme were increased by triiodothyronine treatment at a similar rate in both the young and old rats, but the absolute increments were lower in the old animals.
(6) The TRH treatment suppressed mitochondrial cytochrome c reductase and glucose-6-phosphatase activities, whereas cyclo(His-Pro) reduced cytochrome c reductase and malic enzyme activities.
(7) Activities of glucose-6-phosphate dehydrogenase and malic dehydrogenase of the mycelial form were higher than those of the yeast form.
(8) These observations suggest that in the rat neostriatum there are some neurons especially able to catabolize pyruvate via cytosolic malic isoenzyme.
(9) Thus a long-lived event in thyroid hormone stimulation of malic enzyme synthesis occurred prior to transcription of a specific messenger RNA (mRNA), presumably malic enzyme mRNA.
(10) In the Ob 17 preadipocyte cell line, during adipose differentiation, T3 amplified the progressive expression of two enzymes of the lipogenic pathway, ATP-citrate lyase (ATP-CL) and malic enzyme (ME) as previously described for fatty acid synthase (FAS) and fatty acid synthesis, and in the same time-period of development.
(11) The nucleotide sequence of the mRNA for malic enzyme ((S)-malate NADP+ oxidoreductase (oxaloacetate-decarboxylating, EC 1.1.1.40) from rat liver was determined from three overlapping cDNA clones.
(12) The specific nuclear binding of triiodothyronine (T3) (NBT3) and the activity of malic enzyme (ME), glucose-6-phosphate-dehydrogenase (G6PD), and 6-phosphogluconate-dehydrogenase (6PGD) were studied in the human fibroblast cell (MRC-5).
(13) 2-Hydroxyisobutyric acid, ethyl-2-hydroxybutyrate, malic acid, 1-butanol, benzyl alcohol and L-leucine did not act as substrates for the enzymes.
(14) Malic enzyme and glucose-6-phosphate dehydrogenase were highly active in the adipose tissue of mammals but were inactive in the adipose tissue of birds.
(15) Distribution of kinase activity in centrifugal fractions of both liver and heart mitochondrial sonicates was parallel to that of the two inner membrane marker enzymes succinic dehydrogenase and cytochrome oxidase and quite different from that of the matrix enzyme malic dehydrogenase.
(16) Glucose-6-phosphate dehydrogenase, 6-phosphogluconate dehydrogenase and malic enzyme are enzymes involved in NADPH synthesis.
(17) The antigenic enzymes, the precipitates of which are only stained by specific staining, are: aldolase, malic enzyme, acid phosphatase, peroxydase and cholinesterase.
(18) The coupling enzymes, fumarase (fumarate to L-malate) and malic enzyme (L-malate to pyruvate and NADPH), are adsorbed to nitrocellulose prior to blotting.
(19) The latter region apparently includes the malic dehydrogenase-1 gene.
(20) Some reactions, such as malic enzyme and glutamate dehydrogenase, may be inhibited or deleted with little or no adverse effect on the calculated cell growth rate.