(a.) Disordered; especially, disordered in mind; crazy; insane.
Example Sentences:
(1) It is not known whether the deposits are primary or secondary events, but they may be of importance in initiating or maintaining derangement in heart function.
(2) All of them had fever, jaundice, abdominal pain, leucocytosis and deranged liver function while 26.6% were in shock, 13.3% in coma and 40% in azotaemia.
(3) In patients with Cushing's disease or Nelson's syndrome ACTH secretion is insensitive to naloxone, presumably because of an autonomous pituitary adenoma or hypothalamic derangement.
(4) The high ratio observed in BALF from patients with sarcoidosis and a chronic derangement of alveolar structure suggests either an increased C2 production or an alternative complement pathway (C2-independent) activation within their lungs.
(5) Progress is our understanding of the roles of vasogenic and cytotoxic brain edema in secondary brain damage can be expected from studies of the ability of biochemical factors to open the blood-brain barrier, derange the microcirculation, and cause cell swelling and necrosis.
(6) We assert that OCD and AVN are relatively common, clinically significant lesions of the mandibular condyle often associated with preexisting internal derangement of the temporomandibular joint.
(7) A hypothesis is presented as to how certain occlusal relationships and habitual patterns of jaw use may predispose an individual to TMJ internal derangements.
(8) These data suggest the feasibility of using calcium and EDTA infusions combined with an intact PTH assay to define the relationships between circulating levels of PTH-(1-84) and calcium in states of normal and deranged parathyroid physiology.
(9) Functionally, the first component reflected 55% of the reducibility property and an unimpaired oxidizability property, while the latter exhibited derangement of both aspects of cytochrome c activity.
(10) Laboratory investigations revealed hyperbilirubinemia, marked increase in serum transaminases, a variable alkaline phosphatase level and electrolytes derangement.
(11) Understanding how steroids work has led to improved comprehension of such derangements of hormonal regulation as testicular feminization.
(12) A case of a patient with a malignant schwannoma, who was originally diagnosed as having internal derangement of the temporomandibular joint (TMJ), is presented.
(13) The consequence of these derangements is often widespread plugging of small bronchi and bronchioles.
(14) The deranged adenosine metabolism and raised cAMP in the platelets of this child with severe combined immunodeficiency may explain the altered response to ADP.
(15) Surgery has been important in the treatment of internal derangement of the TMJ.
(16) Biopsies of lumbar multifidus muscles were obtained at operation on seventeen patients aged from fifteen to fifty-eight with lumbar spinal derangement, and further material was taken from the cadavers of three subjects aged from nineteen to fifty-one.
(17) Infection, compression and metabolic derangement were implicated as the most common etiologic factors.
(18) The rate of decline of creatinine clearance, the changes of the urinary protein loss, of total serum protein, of the daily insulin requirement, of the nutritional status and of some hormonal derangements were examined.
(19) Respiratory and circulatory derangements and brain damage ensue if the problem is not promptly recognized and corrected.
(20) It has been suggested that the occurrence of an intracellular Ca2+ overload may result in the development of diabetic cardiomyopathy, which is associated with depletion of high-energy phosphate stores and a derangement of ultrastructure and cardiac dysfunction.
Mad
Definition:
(n.) A slattern.
(n.) The name of a female fairy, esp. the queen of the fairies; and hence, sometimes, any fairy.
() p. p. of Made.
(superl.) Disordered in intellect; crazy; insane.
(superl.) Excited beyond self-control or the restraint of reason; inflamed by violent or uncontrollable desire, passion, or appetite; as, to be mad with terror, lust, or hatred; mad against political reform.
(superl.) Proceeding from, or indicating, madness; expressing distraction; prompted by infatuation, fury, or extreme rashness.
(superl.) Extravagant; immoderate.
(superl.) Furious with rage, terror, or disease; -- said of the lower animals; as, a mad bull; esp., having hydrophobia; rabid; as, a mad dog.
(superl.) Angry; out of patience; vexed; as, to get mad at a person.
(superl.) Having impaired polarity; -- applied to a compass needle.
(v. t.) To make mad or furious; to madden.
(v. i.) To be mad; to go mad; to rave. See Madding.
(n.) An earthworm.
Example Sentences:
(1) Do [MPs] remember the madness of those advertisements that talked of the cool fresh mountain air of menthol cigarettes?
(2) Right from the beginning, I had been mad about movies.
(3) "This will be not only be a postcode lottery, but a States vs Europe lottery and that would be madness."
(4) It took years of prep work to make this sort of Übermensch thing socially acceptable, let alone hot – lots of “legalize it!” and “you are economic supermen!” appeals to the balled-and-entitled toddler-fists of the sociopathic libertechian madding crowd to really get mechanized mass-death neo-fascism taken mainstream .
(5) Or perhaps the "mad cow"-fuelled beef war in the late 1990s, when France maintained its ban on British beef for three long years after the rest of the EU had lifted it, prompting the Sun to publish a special edition in French portraying then president Jacques Chirac as a worm.
(6) • +33 2 98 50 10 12, hotel-les-sables-blancs.com , doubles from €105 room only Hôtel Ty Mad, Douarnenez Hôtel Ty Mad In the 1920s the little beach and fishing village of Douarnenez was a favourite haunt of the likes of Pablo Picasso and writer and artist Max Jacob.
(7) If you’re against the RFS, you’re going to make Iowans mad, you’re going to [have] some Iowans question you but the beauty of Iowa is you can take your case to the people,” said Kaufmann.
(8) In its more loose, common usage, it's a game in which the rivalry has come to acquire the mad, rancorous intensity of a Celtic-Rangers, a Real Madrid-Barcelona, an Arsenal-Tottenham, a River Plate-Boca Juniors.
(9) Yes, we can assign more or less responsibility – I blame Austria-Hungary and Germany for their mad determination to destroy Serbia knowing that a general war might result – but there is still plenty of room for disagreement.
(10) It’s good to hear a full-throated defence of social security as a basic principle of civilisation, and a reiteration of the madness of renewing Trident; pleasing too to behold how much Burnham and Cooper have had to belatedly frame their arguments in terms of fundamental principle.
(11) The blue skipping rope – that’s the key to this race.” My eight-year-old daughter looked at me like I was mad … but when it came time for the year 3 skipping race, she did as she was told – and duly chalked up a glorious personal best in third place.
(12) The policies of zero tolerance equip local and federal law-enforcement with increasingly autocratic powers of coercion and surveillance (the right to invade anybody's privacy, bend the rules of evidence, search barns, stop motorists, inspect bank records, tap phones) and spread the stain of moral pestilence to ever larger numbers of people assumed to be infected with reefer madness – anarchists and cheap Chinese labour at the turn of the 20th century, known homosexuals and suspected communists in the 1920s, hippies and anti-Vietnam war protesters in the 1960s, nowadays young black men sentenced to long-term imprisonment for possession of a few grams of short-term disembodiment.
(13) Maleic acid dimethylester (MAD) was investigated in acute and subacute dermal toxicity studies, for sensitization potential, and for in vivo and in vitro genotoxicity.
(14) Or maybe it's the other way round - the constant touring is a manifestation of their madness.
(15) And while one may think that the bishops of the Church of England don’t quite have the sex appeal of Russell Brand, we think that we should counter it.” While the bishops stress that their letter is not intended as “a shopping list of policies we would like to see”, they do advocate a number of specific steps, including a re-examination of the need for Trident, a retention of the commitment to funding overseas aid and a reassessment of areas where regulations fuel “the common perception of ‘health and safety gone mad’”.
(16) He still thinks Labour was mad to get him of all people to work inside the system.
(17) That has changed over the past few years as wallpaper has made a comeback and women have remembered that they like wearing madly patterned dresses – particularly leopard-print ones, or ones with huge flowers.
(18) Seeing the performance later in Edinburgh, I was impressed by Briers' ability to encompass the hero's rage and madness.
(19) It would be hard to allow working from home if I thought that they were all watching box sets of Mad Men.
(20) People thought she'd gone mad, but in retrospect it's clear that this was precisely what she needed in order to move forward.