(a.) Destitute or deprived of inhabitants; deserted; uninhabited; hence, gloomy; as, a desolate isle; a desolate wilderness; a desolate house.
(a.) Laid waste; in a ruinous condition; neglected; destroyed; as, desolate altars.
(a.) Left alone; forsaken; lonely; comfortless.
(a.) Lost to shame; dissolute.
(a.) Destitute of; lacking in.
(v. t.) To make desolate; to leave alone; to deprive of inhabitants; as, the earth was nearly desolated by the flood.
(v. t.) To lay waste; to ruin; to ravage; as, a fire desolates a city.
Example Sentences:
(1) Downtown LA is improving, but for years it was a desolate hell zone of freeways, office blocks and closed stores.
(2) The coast here feels like an island, desolate and full of surprises.
(3) The Eritrean government requires every pupil to complete their final year of high school by serving in Sawa Military Camp, in the desolate, semi-desert region of eastern Eritrea .
(4) But for the next few hours, though, there's little to excite us: Joseph Weisenthal (@TheStalwart) The economic data calendar is a desolate wasteland of nothingness.
(5) When it is not clogged with weekend traffic, Container – the English word is used in Arabic – is a desolate spot: a lonely stretch of asphalt, four dingy tollbooth-like structures painted white and green, a few bored Israeli soldiers with automatic rifles.
(6) They are kept in a small pen behind the Lion's Den, a pub on a ranch in desolate countryside 75 miles south of Johannesburg.
(7) It was after the Indian wars of the 1870s that the indigenous tribes started to be consigned to reservations – on the worst, most desolate lands for grazing or growing crops.
(8) And, Jinkyo-En which was a desolate waste has come to an oasis in life for the Hansenites.
(9) The first time I saw the building - a stark, unapologetically angular silver bunker throwing back the heat of a rather desolate part of Berlin - I was content to register its disturbance without question, submitting to its strategies of oppression and disorientation as a child would.
(10) "Given the complexity of this crisis and the extent of the distress of our people from the north … we must together, I say together, clear the path ahead to free our country from these invaders, who only leave desolation, deprivation and pain in their wake."
(11) And it's Christmas bonanza time along the high streets of Britain, where Oxfam outlets and estate agents lie lonely amid empty sites and desolate closed doors.
(12) Australian visual effects wizard Dave Clayton has been nominated for his work on The Hobbit: The Desolation of Smaug.
(13) But, like many streets in New York City and in cities across the US, it is becoming increasingly desolate.
(14) Season two crafted complex characters racked with existential ambivalence – heroines marked for the abyss, fragile, flammable outcasts and desolate prodigies, all of whose private pain was as palpable as the crimson bloodbath head witch Evelyn Poole soaks in.
(15) Instead, they suggest expanding the scope of services in family planning clinics, out of an awareness that the continuing high prevalence of unintended childbearing, among the young and disadvantaged in particular, is part of a larger problem of living in a desolate social environment.
(16) "I watched this guy brushing off dirt from a skull in the most desolate landscape and right then I just knew," Rincón said of his first encounter with palaeontology.
(17) There was nothing to see for miles but sage-covered high desert, a landscape of stark beauty and eerie desolation.
(18) The contemporary state of the sub-discipline of endocrinology within the framework of internal medicine is generally considered rather desolate, but so far actual data were lacking.
(19) Howell said in July: "There are large uninhabited and desolate areas, certainly up in the north-east where there's plenty of room for fracking well away from anyone's residence where it can be conducted without any kind of threat to the rural environment."
(20) A subroutine called DESOL for the numerical solution of ordinary differential equations of the type arising in biological simulation problems is described.
Isolate
Definition:
(v. t.) To place in a detached situation; to place by itself or alone; to insulate; to separate from others.
(v. t.) To insulate. See Insulate.
(v. t.) To separate from all foreign substances; to make pure; to obtain in a free state.
Example Sentences:
(1) A series of human cDNA clones of various sizes and relative localizations to the mRNA molecule were isolated by using the human p53-H14 (2.35-kilobase) cDNA probe which we previously cloned.
(2) On the other hand, human IL-9, which is a homologue to murine P40, was cloned from a cDNA library prepared with mRNA isolated from PHA-induced T-cell line (C5MJ2).
(3) Open field behaviors and isolation-induced aggression were reduced by anxiolytics, at doses which may be within the sedative-hypnotic range.
(4) The ability of azelastine to influence antigen-induced contractile responses (Schultz-Dale phenomenon) in isolated tracheal segments of the guinea-pig was investigated and compared with selected antiallergic drugs and inhibitors of arachidonic acid metabolism.
(5) One thing seems to be noteworthy in their opinion: the bacterial resistance of the germs isolated from the urine is bigger than the one of the germs isolated from the respiratory apparatus.
(6) Thus, saponin and ammonium chloride can be used to isolate whole infected erythrocytes, depleted of hemoglobin, by selective disruption of uninfected cells.
(7) Detergent-solubilized HLA antigens were isolated from a human lymphoblastoid cell using an anti-beta2-microglobulin immunoaffinity column.
(8) A phytochemical investigation of an ethanolic extract of the whole plant of Echites hirsuta (Apocynaceae) resulted in the isolation and identification of the flavonoids naringenin, aromadendrin (dihydrokaempferol), and kaempferol; the coumarin fraxetin; the triterpene ursolic acid; and the sterol glycoside sitosteryl glucoside.
(9) The present findings indicate that the deafferented [or isolated] hypothalamus remains neuronally isolated from the environment if the operation is carried out later than the end of the first week of life.
(10) Proliferation assays using F3 showed that 15 (14 CD4+ and 1 CD8+) of the 18 isolated clones were specific for T. gondii.
(11) Similar to intact crayfish, animals with an isolated protocerebrum-eyestalk complex, exhibit competent circadian rhythms in the electroretinogram (ERG).
(12) Reiteration VII (within protein coding regions of genes US10 and US11) and reiteration IV (within introns of genes US1 and US12) were stable between the isolates (group 1).
(13) The role of O2 free radicals in the reduction of sarcolemmal Na+-K+-ATPase, which occurs during reperfusion of ischemic heart, was examined in isolated guinea pig heart using exogenous scavengers of O2 radicals and an inhibitor of xanthine oxidase.
(14) The agent present in the serum which causes dissolution of the fibrin clot was isolated and identified as pepsinogen.
(15) Completeness of isolation of the coronary and systemic circulations was shown by the marked difference in appearance times between the reflex hypotensive responses from catecholamine injections into the isolated coronary circulation and the direct hypertensive response from a similar injection when the circulations were connected as well as by the marked difference between the pressure pulses recorded simultaneously on both sides of the aortic balloon separating the two circulations.4.
(16) At the same time the duodenum can be isolated from the stomach and maintained under constant stimulus by a continual infusion at regulated pressure, volume and temperature into the distal cannula.
(17) Only the approximately 2.7 kb mRNA species was visualized in Northern blots of total cellular and poly(A+) RNA isolated from cardiac ventricular muscle.
(18) These major departmental transformations are being run in isolation from each other.
(19) This postulate is supported by a limited study of the serovars present among the isolates.
(20) Plasma membranes were isolated from rat kidney and their transport properties for sodium, calcium, protons, phosphate, glucose, lactate, and phenylalanine were investigated.