(v. i.) To be hopeless; to have no hope; to give up all hope or expectation; -- often with of.
(v. t.) To give up as beyond hope or expectation; to despair of.
(v. t.) To cause to despair.
(n.) Loss of hope; utter hopelessness; complete despondency.
(n.) That which is despaired of.
Example Sentences:
(1) Crushing their dream of denying healthcare to millions of people will put them on that road to despair.
(2) It was the ease with which minor debt could slide into a tangle of hunger and despair.
(3) The behavioural despair test is a good complement for screening except for drugs having a beta-agonist activity, it appears that this test is dependent on functional relationships between alpha 2 and serotonergic systems.
(4) It became his task to use his literary art in an opposite way to Hesse, even though he despaired of what literature might achieve or of the capacity of rich Europeans to change.
(5) He has his job to do and he has to do it the way he thinks best.” On Saturday night, in a sign of the growing concern at the top of the party about the affair, one shadow cabinet member told the Observer : “The issue is already echoing back at us on the doorsteps.” At all levels, there was despair that the furore had turned the spotlight on to Labour’s difficulties as a time when the party had hoped to take advantage of the Tories’ second byelection loss at the hands of Ukip.
(6) Many have been driven to a suicidal despair that only those devoid of human empathy can fail to understand.
(7) In recent weeks a number of suicides apparently linked to financial despair have hit the headlines.
(8) "You can get six, seven or eight calls a day, which would add to anyone's despair and depression.
(9) Thus in your own words you have said why it was utterly inappropriate for you to use the platform of a Pac hearing in this way.” He suggested that many professionals were “in despair at the lack of understanding and cheap haranguing which characterise your manner” after a series of hearings at which Hodge has led fierce interrogations of senior business figures and others.
(10) For Foos, arousal often competed with despair and sadness at what he witnessed.
(11) | Hugh Muir Read more Wherever Labour people gather to discuss how to break out of the vice tightening around the party, answers fail amid sighs of utter despair.
(12) The presumed interrelation between early rearing conditions and the neurobiological status of the infant that might lead to increased risk for despair is not understood.
(13) Erik Erikson used the film character of Dr. Borg from Wild Strawberries to flesh out his life cycle conception of ego integrity versus despair in old age.
(14) But the character – compounded of piercing sanity and existential despair, infinite hesitation and impulsive action, self-laceration and observant irony – is so multi-faceted, it is bound to coincide at some point with an actor’s particular gifts.
(15) He is an innately optimistic character as well as a clever one, and a man who needs to persuade his party not to despair.
(16) The present report deals with the effects of CBZ on two animal models of depression, namely the potentiation of amphetamine-induced anorexia, and the behavioral despair model.
(17) That is the secret of his repetitive name (like Nabokov's criminal hero in his novel Despair: Hermann Hermann, a misprint for Mr Man Mr Man).
(18) On the one hand, he genuinely sees himself as the great liberator of the poor, the man who wept at Britain’s modern-day penury on Glasgow’s Easterhouse estate; on the other, he is the champion of policies that have driven some of the poorest people in society into despair.
(19) Ovariectomy changed the swimming time course and increased the rhythmical index of depression without other serious disturbances of the behavioural "despair" test.
(20) I wanted to rediscover my joy in writing, I wanted to leave behind the heaviness and despair of Dead Europe .
Sadness
Definition:
(n.) Heaviness; firmness.
(n.) Seriousness; gravity; discretion.
(n.) Quality of being sad, or unhappy; gloominess; sorrowfulness; dejection.
Example Sentences:
(1) She loved us and we loved her.” “We would have loved to have had a little grandchild from her,” she says sadly.
(2) Wimbledon said the world No1 Williams had been suffering from a viral illness and it was a sad and bizarre end to the American’s tournament, not to mention a worrying sight, seeing her hardly able to play.
(3) Sadly, the bullet will not only kill off Greece’s future in Europe.
(4) Calum MacLean, Grangemouth Petrochemicals chairman, says, “This is a hugely sad day for everyone at Grangemouth.
(5) Sadly, the Jewish fanatic who assassinated Rabin in 1995 achieved his broader aim of derailing the peace train.
(6) It also devalues the courage of real whistleblowers who have used proper channels to hold our government accountable.” McCain added: “It is a sad, yet perhaps fitting commentary on President Obama’s failed national security policies that he would commute the sentence of an individual that endangered the lives of American troops, diplomats, and intelligence sources by leaking hundreds of thousands of sensitive government documents to WikiLeaks, a virulently anti-American organisation that was a tool of Russia’s recent interference in our elections.” WikiLeaks last year published emails hacked from the accounts of the Democratic National Committee and John Podesta, chairman of Hillary Clinton’s election campaign.
(7) I watched as she made the briefest eye contact with me on their way back, the flicker of hurt and sadness in her eyes reflecting mine, before the shutters came down.
(8) Only at 3 days did total plasma volume of SAD rats show a modest reduction of about 16% (P less than 0.05 vs. sham-operated plus unoperated controls).
(9) These sad numbers show that more Washington spending, threats of higher taxes on small businesses, and excessive government regulations don't create a healthy environment for job growth," Boehner said.
(10) Thirty-two nursing students were shown silent films in which 10 normal and 10 schizophrenic women described a happy, sad, and an angry personal experience.
(11) World Wildlife Fund Great Barrier Reef campaigner Richard Leck said it was a sad day for the reef and anyone who cared about its future.
(12) It is so sad, we don’t let her go out even if the weather is nice,” he says.
(13) During interviews, married couples experiencing infertility reported emotional reactions such as sadness, depression, anger, confusion, desperation, hurt, embarrassment, and humiliation.
(14) Half of the rats in each group had SAD surgery 1 week prior to study.
(15) There’s an overwhelming sadness among kids like that who have been kept there for a very long time.
(16) It is sadly slightly the territory we have inherited,” he said.
(17) In a statement the family said they were left "extremely sad and disappointed" by the verdicts: "We appreciate the work and effort over the years since events on Broadwater Farm that night in trying to bring people to justice.
(18) Moreover, no differences were found in abnormal lung function patients with and those without SAD in demographic, clinical, roentgenologic, and serologic features and results of pulmonary function tests.
(19) It is sad that the BBC chose to give Nick Griffin a platform.
(20) The only thing I'd say is that I know, from people who've told me firsthand, that sadly mixed marriages can be a bit conflicted on everyday issues.