(n.) An act of malice, hatred, or defiance; contemptuous defiance; a deed of contempt.
(n.) To vex; to annoy; to offend contemptuously.
(prep.) In spite of; against, or in defiance of; notwithstanding; as, despite his prejudices.
Example Sentences:
(1) Direct fetal digitalization led to a reduction in umbilical artery resistance, a decline in the abdominal circumference from 20.3 to 17.8 cm, and resolution of the ascites within 72 h. Despite this dramatic response to therapy, fetal death occurred on day 5 of treatment.
(2) The rise of malaria despite of control measures involves several factors: the house spraying is no more accepted by a large percentage of house holders and the alternative larviciding has only a limited efficacy; the houses of American Indians have no walls to be sprayed; there is a continuous introduction of parasites by migrants.
(3) During and after the infusion of 5HTP, none of the patients showed an increase in anxiety or depressive symptoms, despite the presence of severe side effects.
(4) The extreme quenching of the dioxetane chemiluminescence by both microsomes and phosphatidylcholine, as a model phospholipid, implies that despite the low quantum yield (approx.
(5) Despite of the increasing diagnostic importance of the direct determination of the parathormone which is at first available only in special institutions in these cases methodical problems play a less important part than the still not infrequent appearing misunderstanding of the adequate basic disease.
(6) Despite their absence, photoreceptors maintained a normal rate of OS assembly.
(7) In conclusion, abdominal Marlex-mesh rectopexy can be recommended as safe and effective treatment for rectal prolapse, despite some patients developing constipation and some remaining incontinent.
(8) Despite a 10-year deadline to have the same number of ethnic minority officers in the ranks as in the populations they serve, the target was missed and police are thousands of officers short.
(9) The enzyme, when assayed as either a phospholipase A2 or lysophospholipase, exhibited nonlinear kinetics beyond 1-2 min despite low substrate conversion.
(10) It was also shown that after a shock at 44 degrees C teratocarcinoma cells were able to accumulate anomalous amounts of hsp 70 despite hsp 70 synthesis inhibition.
(11) In addition, despite the fact that the differences constitutes an information bias, the bias occurs in the same direction and magnitude in all the various subgroups and thus is nondifferential.
(12) Despite this alteration in subcellular distribution, the mutant polypeptide retained the ability to induce fibroblast transformation by several parameters, including the ability to display anchorage-independent growth.
(13) Despite significant differences in mean response, there was a large overlap of individual responses between diagnostic subgroups.
(14) (4) Despite the removal of the cruciate ligaments and capsulo-ligamentous slide, no significant residual instability was found in either plane.
(15) Lung metastases leading to death were observed in one patient with small-cell osteosarcoma despite complete destruction of the primary tumor by preoperative chemotherapy.
(16) When antibodies were bound to cell-surface DPP IV at 4 degrees C, the immune complex remained stable for more than 1 h after rewarming to 37 degrees C, despite ongoing metabolic and membrane transport processes.
(17) John Lewis’s marketing, advertising and reputation are all built on their promises of good customer services, and it is a large part of what still drives people to their stores despite cheaper online outlets.
(18) Despite the nearly anaerobic state of the ascites tumor fluid in vivo, cancer cells suspended in this fluid oxidized FFA at least as fast as they do in vitro under aerobic conditions.
(19) Conservatively treated compressed fractures of the distal radius dorsal metaphysis healed despite primarily good reduction and consequent treatment with a decrease in dorsal length.
(20) The diagnosis of an arterial injury may be readily apparent, but the excellent upper-extremity collateral circulation may create palpable distal pulses despite a significant proximal arterial injury.
Malice
Definition:
(n.) Enmity of heart; malevolence; ill will; a spirit delighting in harm or misfortune to another; a disposition to injure another; a malignant design of evil.
(n.) Any wicked or mischievous intention of the mind; a depraved inclination to mischief; an intention to vex, annoy, or injure another person, or to do a wrongful act without just cause or cause or excuse; a wanton disregard of the rights or safety of others; willfulness.
(v. t.) To regard with extreme ill will.
Example Sentences:
(1) After addition of triiodothyronine, malic enzyme mRNA accumulated with sigmoidal kinetics, approaching a new steady state at 36-48 h after adding hormone.
(2) In addition to detecting three major antigenic variants of malic enzyme within this group, both antisera readily reacted with Streptococcus faecalis malic enzyme.
(3) The oxidative enzymes of the pentose phosphate pathway, ATP-citrate lyase, 'malic' enzyme and fatty acid synthetase also decrease markedly.
(4) Hormone therapy also caused an increase in the rate of incorporation of [3H]leucine into soluble proteins and in malic enzyme activity.
(5) Moreover, the transcriptional rate, mRNA concentration and induction of malic enzyme were increased by triiodothyronine treatment at a similar rate in both the young and old rats, but the absolute increments were lower in the old animals.
(6) The TRH treatment suppressed mitochondrial cytochrome c reductase and glucose-6-phosphatase activities, whereas cyclo(His-Pro) reduced cytochrome c reductase and malic enzyme activities.
(7) Activities of glucose-6-phosphate dehydrogenase and malic dehydrogenase of the mycelial form were higher than those of the yeast form.
(8) These observations suggest that in the rat neostriatum there are some neurons especially able to catabolize pyruvate via cytosolic malic isoenzyme.
(9) Thus a long-lived event in thyroid hormone stimulation of malic enzyme synthesis occurred prior to transcription of a specific messenger RNA (mRNA), presumably malic enzyme mRNA.
(10) In the Ob 17 preadipocyte cell line, during adipose differentiation, T3 amplified the progressive expression of two enzymes of the lipogenic pathway, ATP-citrate lyase (ATP-CL) and malic enzyme (ME) as previously described for fatty acid synthase (FAS) and fatty acid synthesis, and in the same time-period of development.
(11) The nucleotide sequence of the mRNA for malic enzyme ((S)-malate NADP+ oxidoreductase (oxaloacetate-decarboxylating, EC 1.1.1.40) from rat liver was determined from three overlapping cDNA clones.
(12) The specific nuclear binding of triiodothyronine (T3) (NBT3) and the activity of malic enzyme (ME), glucose-6-phosphate-dehydrogenase (G6PD), and 6-phosphogluconate-dehydrogenase (6PGD) were studied in the human fibroblast cell (MRC-5).
(13) 2-Hydroxyisobutyric acid, ethyl-2-hydroxybutyrate, malic acid, 1-butanol, benzyl alcohol and L-leucine did not act as substrates for the enzymes.
(14) Malic enzyme and glucose-6-phosphate dehydrogenase were highly active in the adipose tissue of mammals but were inactive in the adipose tissue of birds.
(15) Distribution of kinase activity in centrifugal fractions of both liver and heart mitochondrial sonicates was parallel to that of the two inner membrane marker enzymes succinic dehydrogenase and cytochrome oxidase and quite different from that of the matrix enzyme malic dehydrogenase.
(16) Glucose-6-phosphate dehydrogenase, 6-phosphogluconate dehydrogenase and malic enzyme are enzymes involved in NADPH synthesis.
(17) The antigenic enzymes, the precipitates of which are only stained by specific staining, are: aldolase, malic enzyme, acid phosphatase, peroxydase and cholinesterase.
(18) The coupling enzymes, fumarase (fumarate to L-malate) and malic enzyme (L-malate to pyruvate and NADPH), are adsorbed to nitrocellulose prior to blotting.
(19) The latter region apparently includes the malic dehydrogenase-1 gene.
(20) Some reactions, such as malic enzyme and glutamate dehydrogenase, may be inhibited or deleted with little or no adverse effect on the calculated cell growth rate.