(a.) Causing destruction; tending to bring about ruin, death, or devastation; ruinous; fatal; productive of serious evil; mischievous; pernicious; -- often with of or to; as, intemperance is destructive of health; evil examples are destructive to the morals of youth.
(n.) One who destroys; a radical reformer; a destructionist.
Example Sentences:
(1) But soon after aid workers departed, barrel bombs dropped by Syrian helicopters caused renewed destruction.
(2) High mortality, severe destruction of pancreatic B-cells and presence of sporadic mononuclear infiltrations in islets and around excretory ducts were observed.
(3) Lung metastases leading to death were observed in one patient with small-cell osteosarcoma despite complete destruction of the primary tumor by preoperative chemotherapy.
(4) Since alkaline phosphatase, a glycoprotein, is not affected, the destruction is selective and presumably involves only the most exposed membrane components.
(5) Intravenous urography revealed destruction of the right kidney resembling Wilms tumor.
(6) Lawmakers across the globe are beginning to recognize the need to deter this destructive conduct.
(7) Finally, the uptake was completely abolished by prior mechanical or osmotic destruction of the intima.
(8) The weapon is 13 metres long, weighs 60 tonnes and can carry nuclear warheads with up to eight times the destructive capacity of the bombs that hit Hiroshima and Nagasaki in the second world war.
(9) While a clearcut relationship cannot be established between heavy metal music and destructive behavior, evidence shows that such music promotes and supports patterns of drug abuse, promiscuous sexual activity, and violence.
(10) Quite the contrary, in cases of higher nervous activity disturbances, destruction of the organelles and desintegration of spine apparatuses is clearly pronounced.
(11) Granule cell destruction began early, and was widespread by 2 days in vitro, when oligodendrocyte destruction also began in treated cultures.
(12) The ferrochelatase-inhibitory activity, porphyrin-inducing activity, and cytochrome P-450- and heme-destructive effects of a variety of analogues of 3,5-diethoxycarbonyl-1,4-dihydro-2,4,6-trimethylpyridine (DDC) were studied in chick embryo liver cells.
(13) A simple technique that consists of curetting the subcutaneous tissue in the necrotic area of the lesion, to prevent the local destructive actions of the toxin, is described.
(14) The high proteolytic activity of BCC demonstrated in this study may be an important factor in the proliferative, invasive and destructive behaviour of this tumour.
(15) North Korea has produced tons of propaganda films that portray America’s destruction.
(16) The object of these studies was to investigate whether destruction of the renal medulla in normal rats would alter vascular capacitance.
(17) We simply do whatever nature needs and will work with anyone that wants to help wildlife.” His views might come as a surprise to some of the RSPB’s 1.1 million members, who would have been persuaded by its original pledge “to discourage the wanton destruction of birds”; they would equally have been a surprise to the RSPB’s detractors in the shooting world.
(18) The tissue destructive process is slower in older than in younger people, and the prognoses in correctly treated cases is good.
(19) Although these two destructive entities are completely different in many respects, they share a common denominator: the initial lesions are brought about by an aggregate of bacteria known as plaque.
(20) It is concluded that the massive destruction of the normal anatomy in the lateral semicircular canal may be the morphological basis of a functional endolymphatic fistula for drainage of the endolymphatic hydrops.
Pernicious
Definition:
(a.) Having the quality of injuring or killing; destructive; very mischievous; baleful; malicious; wicked.
(a.) Quick; swift (to burn).
Example Sentences:
(1) To investigate the possibility that an abnormality of gastric emptying exists in duodenal ulcer and to determine if such an abnormality persists after ulcer healing, scintigraphic gastric emptying measurements were undertaken in 16 duodenal ulcer patients before, during, and after therapy with cimetidine; in 12 patients with pernicious anemia, and in 12 control subjects.
(2) Urinary excretion of (60)Co radioactivity in pernicious anemia patients after oral administration of (60)Co-vitamin B(12) bound to freshly prepared (125)I-labeled IF was similar to that obtained with noniodinated intrinsic factor.
(3) Antibodies to parietal cells were found in 5 cases and 4 patients with pernicious anemia were detected.
(4) Reticulocytes of patients with pernicious anaemia on treatment and with haemolytic anaemia were shown to have higher folate levels than their corresponding mature cells.
(5) Immunofluorescence tests on 94 human sera reacting with rat gastric parietal cells revealed that 41 (44%) of the sera contained antibody to a rat parietal cell antigen that was distinct from the pernicious anaemia autoantigen.
(6) In pernicious anaemia the amount of enzyme is reduced and on this hypothesis the regulatory function impaired.
(7) Six patients without nervous system involvement had normal EEGs, 10 patients with spinal cord or peripheral nervous system involvement had normal or minimally abnormal EEGs, 17 of 19 patients with evidence of mental dysfunction had abnormal EEGs with the most consistent finding being an excess of theta slowing, and 19 patients with pernicious anemia and other neurologic diseases showed EEG findings reflecting the complicating disease process.
(8) This article details the pernicious odontostomatological effects provoked by antitumorous and immunosuppressive medication.
(9) This week, the resilience of Italy’s most pernicious problem – the mafia – was exposed once again when it was announced that Corleone’s town council was being dissolved by the order of Rome because it had been infiltrated by organised crime.
(10) Thus the Type A pattern of gastritis (autoimmune) seen in patients with pernicious anaemia is only rarely associated with Campylobacter like organisms.
(11) Thus, the processing of progastrin adjacent to the active site of gastrin is more restrictively controlled than N-terminal processing during G-cell hypersecretion associated with pernicious anemia.
(12) The early improvement in marrow morphology in patients with pernicious anaemia was greater with 1000 mug than with 5 mug doses of cyanocobalamin.
(13) They were found to have pernicious anemia (PA) and normal adrenal functions.
(14) The EEG was also a good indicator for detecting and confirming other intracranial disease processes unrelated to pernicious anemia.
(15) The endocrine tumours corresponded to the gastric carcinoids found in patients with long-lasting hypergastrinaemia due to pernicious anaemia or with a gastrinoma as part of the MEN I syndrome.
(16) Two vitiligo patients were hypergastrinaemic suggesting latent pernicious anaemia.
(17) 27 patients with pernicious anaemia, followed for a long period, were consecutively treated with three different vitamin B12 preparations, while during intervening period no therapy was given until signs of B12 deficiency developed.
(18) Sixteen control subjects, 13 patients with pernicious anaemia, and four who had had total gastrectomy were studied.
(19) And so while it’s particularly pernicious that some parents pay for months, sometimes years, of tutoring to get their child through an exam that they might well otherwise fail, I know it’s because they are desperate to secure for their child any extra benefit going in a country that is becoming ever more unequal.
(20) This policy, which prevents many travellers and overseas residents from benefitting from one of the most effective prophylactic treatments on the market today, thereby indirectly causing a number of pernicious cases of malaria, is based on the unfounded, unproved premise that wide use of this drug would foster the development of méfloquine-resistance or on side-effects, which are in fact rarely of any consequence and always curable.