(1) Structurally altered polymorphic variants with reduced activity, such as tetrameric interface mutant Ile-58 to Thr, may produce not only an early selective advantage, through enhanced cytotoxicity of tumor necrosis factor for virus-infected cells, but also detrimental effects from increased mitochondrial oxidative damage, contributing to degenerative conditions, including diabetes, aging, and Parkinson's and Alzheimer's diseases.
(2) Samaras said: A "Grexit", as it is called, would be devastating for Greece and detrimental to Europe.
(3) The striking improvements in carbohydrate and lipid metabolism in diabetic and non-diabetic Aborigines after a temporary reversion to a traditional hunter-gatherer lifestyle highlight the potentially reversible nature of the detrimental effects of lifestyle change, particularly in young people who have not yet developed diabetes.
(4) A murine model system was developed to determine whether ionizing radiation has a detrimental influence on thymic epithelium, cell function.
(5) The aim of this study was determine if functional adaptation of NHP and HB position to these detrimental conditions could be observed, using Bonferonni probabilities, in a cephalometric comparison of 38 SAS adults in the wakeful state and a control group of 38 healthy adults.
(6) Together, they dispel the myth that changing initial responses more often is detrimental than beneficial.
(7) Also, studies on the simulated cumulative effect of background radiation during storage failed to find any detrimental effect when embryos were exposed to the equivalent of about 2000 years of background radiation.
(8) The author then describes new approaches to improving the vocational integration of persons with epilepsy, by focussing on the one hand on extending the range of occupational assessment, and the adoption of new job placement assessment, and the adoption of new job placement strategies on the other, which concurrently seek to influence those factors that are detrimental to the occupational outlook of the person with a seizure disorder (notably frequent seizures, psychiatric problems, low educational levels, negative employer attitudes).
(9) The rationale for the inclusion of Mg in cardioplegic solutions therefore lies not in its cardioplegic properties, but in its ability to influence other cellular events such as the loss of Mg and K and perhaps to counter the detrimental effects of ischemia by antagonizing calcium (Ca) overload.
(10) Alternatively, increasing this ratio may permit embryos to reduce the concentration of a substance detrimental to their growth.
(11) Because NMDA receptor antagonists impede certain kinds of learning, and because motor recovery after sensorimotor cortex injury in the rat is dependent on post-lesion experience, we hypothesized that treatment with MK-801 after focal brain injury would be detrimental.
(12) Student participation in school-based suicide prevention programs, however, was associated with a detrimental effect on state teenage suicide rates.
(13) Aggressive or improper toothbrushing techniques may have a detrimental impact on the gingiva.
(14) On this basis we tried to change the milieu on a 26-bed therapeutic community ward which proved to have pseudo-groups and a detrimental ward atmosphere.
(15) In a pediatric critical care environment with skilled ongoing nursing care, the axillary artery can be used as a site for intraarterial monitoring in pediatric patients without a detrimental effect on concurrent or future blood pressure monitoring.
(16) These data suggest that sCR1 inhibits the Arthus reaction by interrupting the activation of the C cascade, hence limiting the detrimental immune complex-induced tissue damage in vivo.
(17) Unreasonable expectations and expansion of the health sector have spawned counterproductive effects which are to some extent detrimental to public health.
(18) Falls among hospitalized patients are common occurrences and can have detrimental effects on patient outcomes.
(19) Nylon drains are available in any operating room, and have no detrimental effects on the grafted skin.
(20) Focal cerebral ischemia initiates multiple detrimental effects in the brain.
Disadvantageous
Definition:
(a.) Attended with disadvantage; unfavorable to success or prosperity; inconvenient; prejudicial; -- opposed to advantageous; as, the situation of an army is disadvantageous for attack or defense.
Example Sentences:
(1) Their disadvantages - the expensive equipment and the time-consuming procedure respectively - limit their widespread use.
(2) One disadvantage of the EHL is that it lacks the fragment-collecting capability that the ultrasound lithotripter features.
(3) Each method has its own advantages and disadvantages.
(4) The diet dilution technique overcomes the major disadvantage of the graded supplementation method for determining the requirements of amino acids, namely that of the amino acid balance changing systematically in successive dietary treatments.
(5) This paper considers the advantages and disadvantages of the instrument together with indications for its use and reviews 118 patients who had 130 oral lesions removed with the CO2 laser.
(6) MCT TPN was found to have some disadvantages, especially with regard to nitrogen balance and plasma albumin levels.
(7) We conclude that acute ischemia induces a mechanical disadvantage which is greater than just the loss of contractile function by the ischemic segment.
(8) Paradigm relies heavily on social science research and analysis to help companies identify and address the specific barriers and unconscious biases that might be affecting their diversity efforts: things like anonymizing resumes so that employers can’t tell a candidate’s gender or ethnicity, or modifying a salary negotiation process that places women and minorities at a disadvantage.
(9) This suggests that there is little survival advantage or disadvantage in the combination of glucose-6-phosphate dehydrogenase deficiency and sickle cell anaemia.
(10) In this paper, the main advantages and disadvantages of the following three techniques, i.e.
(11) We discuss advantages and disadvantages of total randomization, of Zelen-type randomization procedures, of Efron-type procedures vs more classical blocking procedures to control the balance between groups, and of Simon-Pocock-type procedures vs more classical stratification for controlling possible biases in prognostic factors.
(12) This article will review the orthopaedic conditions wherein ankle arthroscopy has utility, the advantages and disadvantages of arthroscopy, and nursing considerations for preoperative, intraoperative, and postoperative patient care.
(13) Changes in the fitness of harmful mutations may therefore impose a greater long-term disadvantage on asexual populations than those which are sexual.
(14) After considering the advantages and disadvantages of preclinical laboratory exercises, they conclude that the former still outweigh the latter.
(15) The right atrial route is considered to be preferable as a primary approach and has no disadvantages.
(16) These were people who had neither disadvantage nor biological risk factors.
(17) Since they were established they have been credited with changing the face of children and family services, identifying disadvantaged children and families and providing targeted support.
(18) This article describes one way of circumventing these disadvantages.
(19) Each case must be assessed on its own premises: the substitution need, the availability of a transplant, the long-term prognosis, and the advantages and disadvantages of a solution with autotransplantation versus solutions without autotransplantation.
(20) Methods, advantages, and disadvantages of electrometry on wounds are reported.