(1) Structurally altered polymorphic variants with reduced activity, such as tetrameric interface mutant Ile-58 to Thr, may produce not only an early selective advantage, through enhanced cytotoxicity of tumor necrosis factor for virus-infected cells, but also detrimental effects from increased mitochondrial oxidative damage, contributing to degenerative conditions, including diabetes, aging, and Parkinson's and Alzheimer's diseases.
(2) Samaras said: A "Grexit", as it is called, would be devastating for Greece and detrimental to Europe.
(3) The striking improvements in carbohydrate and lipid metabolism in diabetic and non-diabetic Aborigines after a temporary reversion to a traditional hunter-gatherer lifestyle highlight the potentially reversible nature of the detrimental effects of lifestyle change, particularly in young people who have not yet developed diabetes.
(4) A murine model system was developed to determine whether ionizing radiation has a detrimental influence on thymic epithelium, cell function.
(5) The aim of this study was determine if functional adaptation of NHP and HB position to these detrimental conditions could be observed, using Bonferonni probabilities, in a cephalometric comparison of 38 SAS adults in the wakeful state and a control group of 38 healthy adults.
(6) Together, they dispel the myth that changing initial responses more often is detrimental than beneficial.
(7) Also, studies on the simulated cumulative effect of background radiation during storage failed to find any detrimental effect when embryos were exposed to the equivalent of about 2000 years of background radiation.
(8) The author then describes new approaches to improving the vocational integration of persons with epilepsy, by focussing on the one hand on extending the range of occupational assessment, and the adoption of new job placement assessment, and the adoption of new job placement strategies on the other, which concurrently seek to influence those factors that are detrimental to the occupational outlook of the person with a seizure disorder (notably frequent seizures, psychiatric problems, low educational levels, negative employer attitudes).
(9) The rationale for the inclusion of Mg in cardioplegic solutions therefore lies not in its cardioplegic properties, but in its ability to influence other cellular events such as the loss of Mg and K and perhaps to counter the detrimental effects of ischemia by antagonizing calcium (Ca) overload.
(10) Alternatively, increasing this ratio may permit embryos to reduce the concentration of a substance detrimental to their growth.
(11) Because NMDA receptor antagonists impede certain kinds of learning, and because motor recovery after sensorimotor cortex injury in the rat is dependent on post-lesion experience, we hypothesized that treatment with MK-801 after focal brain injury would be detrimental.
(12) Student participation in school-based suicide prevention programs, however, was associated with a detrimental effect on state teenage suicide rates.
(13) Aggressive or improper toothbrushing techniques may have a detrimental impact on the gingiva.
(14) On this basis we tried to change the milieu on a 26-bed therapeutic community ward which proved to have pseudo-groups and a detrimental ward atmosphere.
(15) In a pediatric critical care environment with skilled ongoing nursing care, the axillary artery can be used as a site for intraarterial monitoring in pediatric patients without a detrimental effect on concurrent or future blood pressure monitoring.
(16) These data suggest that sCR1 inhibits the Arthus reaction by interrupting the activation of the C cascade, hence limiting the detrimental immune complex-induced tissue damage in vivo.
(17) Unreasonable expectations and expansion of the health sector have spawned counterproductive effects which are to some extent detrimental to public health.
(18) Falls among hospitalized patients are common occurrences and can have detrimental effects on patient outcomes.
(19) Nylon drains are available in any operating room, and have no detrimental effects on the grafted skin.
(20) Focal cerebral ischemia initiates multiple detrimental effects in the brain.
Pernicious
Definition:
(a.) Having the quality of injuring or killing; destructive; very mischievous; baleful; malicious; wicked.
(a.) Quick; swift (to burn).
Example Sentences:
(1) To investigate the possibility that an abnormality of gastric emptying exists in duodenal ulcer and to determine if such an abnormality persists after ulcer healing, scintigraphic gastric emptying measurements were undertaken in 16 duodenal ulcer patients before, during, and after therapy with cimetidine; in 12 patients with pernicious anemia, and in 12 control subjects.
(2) Urinary excretion of (60)Co radioactivity in pernicious anemia patients after oral administration of (60)Co-vitamin B(12) bound to freshly prepared (125)I-labeled IF was similar to that obtained with noniodinated intrinsic factor.
(3) Antibodies to parietal cells were found in 5 cases and 4 patients with pernicious anemia were detected.
(4) Reticulocytes of patients with pernicious anaemia on treatment and with haemolytic anaemia were shown to have higher folate levels than their corresponding mature cells.
(5) Immunofluorescence tests on 94 human sera reacting with rat gastric parietal cells revealed that 41 (44%) of the sera contained antibody to a rat parietal cell antigen that was distinct from the pernicious anaemia autoantigen.
(6) In pernicious anaemia the amount of enzyme is reduced and on this hypothesis the regulatory function impaired.
(7) Six patients without nervous system involvement had normal EEGs, 10 patients with spinal cord or peripheral nervous system involvement had normal or minimally abnormal EEGs, 17 of 19 patients with evidence of mental dysfunction had abnormal EEGs with the most consistent finding being an excess of theta slowing, and 19 patients with pernicious anemia and other neurologic diseases showed EEG findings reflecting the complicating disease process.
(8) This article details the pernicious odontostomatological effects provoked by antitumorous and immunosuppressive medication.
(9) This week, the resilience of Italy’s most pernicious problem – the mafia – was exposed once again when it was announced that Corleone’s town council was being dissolved by the order of Rome because it had been infiltrated by organised crime.
(10) Thus the Type A pattern of gastritis (autoimmune) seen in patients with pernicious anaemia is only rarely associated with Campylobacter like organisms.
(11) Thus, the processing of progastrin adjacent to the active site of gastrin is more restrictively controlled than N-terminal processing during G-cell hypersecretion associated with pernicious anemia.
(12) The early improvement in marrow morphology in patients with pernicious anaemia was greater with 1000 mug than with 5 mug doses of cyanocobalamin.
(13) They were found to have pernicious anemia (PA) and normal adrenal functions.
(14) The EEG was also a good indicator for detecting and confirming other intracranial disease processes unrelated to pernicious anemia.
(15) The endocrine tumours corresponded to the gastric carcinoids found in patients with long-lasting hypergastrinaemia due to pernicious anaemia or with a gastrinoma as part of the MEN I syndrome.
(16) Two vitiligo patients were hypergastrinaemic suggesting latent pernicious anaemia.
(17) 27 patients with pernicious anaemia, followed for a long period, were consecutively treated with three different vitamin B12 preparations, while during intervening period no therapy was given until signs of B12 deficiency developed.
(18) Sixteen control subjects, 13 patients with pernicious anaemia, and four who had had total gastrectomy were studied.
(19) And so while it’s particularly pernicious that some parents pay for months, sometimes years, of tutoring to get their child through an exam that they might well otherwise fail, I know it’s because they are desperate to secure for their child any extra benefit going in a country that is becoming ever more unequal.
(20) This policy, which prevents many travellers and overseas residents from benefitting from one of the most effective prophylactic treatments on the market today, thereby indirectly causing a number of pernicious cases of malaria, is based on the unfounded, unproved premise that wide use of this drug would foster the development of méfloquine-resistance or on side-effects, which are in fact rarely of any consequence and always curable.