(1) It appears that irrespective of the elucidation of the nature of the putative aetiological factor (presumed to be viral) in MS, the arrest and reversal of T cell-related events within the CNS in this devastating condition represent feasible goals and should remain a major target for some time to come.
(2) Samaras said: A "Grexit", as it is called, would be devastating for Greece and detrimental to Europe.
(3) While winds gusting to 170mph caused significant damage, the devastation in areas such as Tacloban – where scenes are reminiscent of the 2004 Indian ocean tsunami – was principally the work of the 6-metre-high storm surge, which carried away even the concrete buildings in which many people sought shelter.
(4) The Financial Services Authority is meant to be the City's watchdog but "devastating" internal documents reveal it has secretly co-ordinated high-level lobbying strategies with the industry it is supposed to police.
(5) The government acknowledged it had been overwhelmed by the devastation from the deadliest quake in Nepal in over 80 years.
(6) Mark Rasch, a cyber crime expert quoted by the FT, meanwhile said recent events have been “a serious and devastating attack to [Sony’s] reputation and image”, and his opinion is played out by a new YouGov poll into the public perception of Sony’s brand.
(7) "When people don't feel they have a reason to stay out of trouble, the consequences for communities can be devastating – as we saw last August," said Darra Singh, chair of the panel.
(8) Newcastle United are “devastated” by their relegation from the Premier League, according to the club’s managing director Lee Charnley.
(9) In order to reduce the devasting effects of enteric diseases among children born to mothers in tropical countries of Africa and Asia, it is imperative that all health workers understand the cultural and social perceptions of their clients towards the disease in question.
(10) All the personality, dignity and humanity of a person are devastated by this torture.
(11) Age UK believes McDonald's human rights have been breached and that there could be "extremely adverse and devastating consequences for many thousands of older people if other councils take similar decisions to save money".
(12) And then, as the Guardian revealed at the weekend, there is the potentially devastating effect of the boundary changes, which can’t really be brought in before an early election but will radically tilt the field by 2020.
(13) He said: "[That] could be devastating for the renewables industry.
(14) To say that the loss of BB King is devastating to the blues community is an understatement.
(15) 'Devastated' Peter Greste calls on Egypt's president to pardon trio Read more “It’s ironic that the conviction was for tarnishing Egypt’s reputation when ... this [case] is what’s tarnished Egypt’s image,” Clooney told BBC News.
(16) The report, extracts of which were published by the investigative news website Exaro , is said to include “devastating detail” of the corporation’s “sheer scale of awareness” of the late star’s activities.
(17) Although anterior and posterior traumatic displacement of cervical vertebrae are commonly noted, and the devastating neurological deficits associated with these injuries have been amply defined, lateral displacement with fractures has been rarely recognized, and the clinical significance of this injury has been overlooked.
(18) Bernard Hogan-Howe, the Met commissioner, said a report revealing the undercover officers had spied on the family of murdered teenager Stephen Lawrence was “devastating” for Scotland Yard and “one of the worst days that I have seen as a police officer”.
(19) The case for halting British arms sales to Saudi Arabia has been evident, not only on moral grounds, since civilians started dying in the conflict devastating Yemen.
(20) Devastating neurologic complications can be avoided or alleviated in a great proportion of patients undergoing radiation therapy for cerebral metastases and spinal cord compression.
Wretched
Definition:
(a.) Very miserable; sunk in, or accompanied by, deep affliction or distress, as from want, anxiety, or grief; calamitous; woeful; very afflicting.
(a.) Worthless; paltry; very poor or mean; miserable; as, a wretched poem; a wretched cabin.
(a.) Hatefully contemptible; despicable; wicked.
Example Sentences:
(1) Servicemen returning from their term of duty would land in San Diego and disappear into the hinterland rather than go home, finding refuge in drugs, alcohol or wretched anonymity.
(2) It was a wretched goal to concede and the unfortunate truth for Mignolet is that moment reminded us why many Liverpool supporters are perplexed he has been awarded a new five-year contract.
(3) We are Uncle Moneybags compared with the wretches who live in Ireland and the United States, where unemployment is higher than it is in Britain.
(4) Admittedly we've had the odd wretched experience – the long wait in casualty or for a bedpan, the horrid puréed dinners, the lost notes – but ultimately we've all been looked after, cured and called back for check-ups and therapies.
(5) Craig Gardner sent a header wide and had a strong claim for a penalty turned down, but West Brom were wretched, and Tony Pulis made two changes at half-time, Chris Brunt coming on for the injured Darren Fletcher, and Salomón Rondón joining the hitherto isolated Victor Anichebe up front after replacing Jonas Olsson.
(6) While Everton mourned Howard Kendall , the architect of two title-winning teams, Van Gaal illustrated the influence an elite manager can have as, from the ruins of a wretched performance in London, he fashioned a more pragmatic, more athletic side.
(7) Kathimerini has the details : Pulled up,,,for using derogatory language, Iliopoulos went further, condemning fellow MPs as "wretched sell-outs" and "goats".
(8) It had been a wretched semi-final until those moments when the players lined up in the centre circle for that last test of nerve and Holland should not just reflect on the inability of Ron Vlaar and Wesley Sneijder to beat the Argentina goalkeeper, Sergio Romero, but also the fact their entire team did not manage a single shot on target during the 120 minutes that preceded the shootout.
(9) The wretched miscreants that swamp Quinn, Sarkeesian and others with vile threats every time they post a video, a story or a tweet, have come to symbolise community.
(10) He is best remembered, however, for his four books: Black Skin, White Masks; Toward the African Revolution; A Dying Colonialism; and The Wretched of the Earth.
(11) He could take the most pitiful souls – his CV was populated almost exclusively by snivelling wretches, insufferable prigs, braggarts and outright bullies – and imbue each of them with a wrenching humanity.
(12) Updated at 10.18pm BST 10.15pm BST 58 min: Rather than play the ball to his team-mate Bernard, who was in a better position on the left-hand side of the penalty area, the wretched Fred shoots weakly from distance, straight at Neuer.
(13) What is clear is that 31-year-old Lynn led an "unimaginably wretched" life through illness which led her to attempt suicide, consider ending her days at Dignitas, the Swiss-based assisted suicide clinic, and sign a "living will" after saying she "feared degeneration and indignity far more than I fear death".
(14) Photograph: AAP In her famous 1913 pamphlet, Round about a pound a week , Maud Pember Reeves wrote contemptuously about “the gospel of porridge” – the idea, still common among the wealthy, that the destitute wouldn’t be so wretched if only they invested their money wisely.
(15) It’s a wretched character, and a truly hateful performance.
(16) So after six days of sustained assault by the world's fourth largest military power on one of its most wretched and overcrowded territories, at least 130 Palestinians had been killed, an estimated half of them civilians, along with five Israelis.
(17) Once again, though, wretched defending cost Celtic any chance of saving the match, let alone the tie.
(18) What does the phrase mean, apart from a wretched violation of the English language in a way that makes a good argument for corporal punishment?
(19) It's so full of the river, and the sense of the city, and a huge stretch of London society, and so grand in its vision that perhaps we forget how gloriously funny it is – the Boffins deciding to go in for history, and buying a big book ("His name is Decline-And-Fall-Off-The-Rooshan-Empire") or the captivating Lady Tippins ("You wretch!
(20) Williamson was not the only player sent off on a wretched day for the visitors, who also had Daryl Janmaat dismissed in the last minute for a second bookable offence.