(1) The antinociceptive activity of the propionyl homologues of 3-O- and 6-O-acetyl- and 3,6-O-diacetylmorphine was re-investigated using materials of unequivocally established structure.
(2) Diacetylmorphine was hydrolyzed twice as rapidly in blood as in serum.
(3) Plasma morphine concentrations were measured by radioimmunoassay because of the rapid conversion of diacetylmorphine to morphine in plasma; repeated blood samples were obtained the first 30 min after injection into the epidural space.
(4) The hepatic extraction of morphine (1.5 mg) was 25%, of diacetylmorphine (1.5 mg) 59%, and of meperidine (1.5 mg) 66% in a single pass, all significantly lower (P less than 0.01) than that of methadone.
(5) Mice were exposed to diacetylmorphine (heroin) or phencyclidine (PCP) prenatally or neonatally.
(6) Significantly lower plasma morphine levels occurred between 3 and 20 min when epinephrine was added to diacetylmorphine.
(7) Other drugs have been less extensively investigated than aspirin and these include heroin (diacetylmorphine), suxamethonium (succinylcholine), clofibrate, carbimazole, procaine and other local anaesthetics.
(8) The abuse of heroin (diacetylmorphine) in Singapore escalated sharply in 1975 and 1976, as indicated by the 35-fold increase in the number of heroin seizures and the 20-fold increase in the urine samples containing morphine since 1974.
(9) A total of 14 substances: 8 opiates (morphine, 6-monoacetylmorphine, diacetylmorphine, codeine, acetylcodeine, noscapine, papaverine and thebaine) and 6 adulterants (ephedrine, quinine, methadone, caffeine, cocaine and strychnine) were used as test samples for this research.
(10) Species differences in the rate of conversion of diacetylmorphine to monacetylmorphine in vitro in blood are also presented.
(11) From the 140 illicit heroin samples analyzed by capillary gas chromatography, 61% had a diacetylmorphine content between 30 and 48%.
(12) The content of morphine, codeine and acetyl products and the ratios of morphine to codeine and heroin to acetylcodeine obtained from opium samples of known origin as well as the content of heroin (diacetylmorphine) and acetylcodeine and their ratios in illicit heroin samples that have been found to belong to the same source of supply as the known opium samples are used as the basic criteria for a comparison to determine the origin of illicit heroin samples.
(13) Epinephrine reduced absorption of diacetylmorphine from the extradural site by at least 55% over the first 30 min.
(14) The number of abnormal fetuses from females injected with diacetylmorphine (heroin), thebaine, phenazocine, pentazocine, propoxyphene, and methadone increased as the maternal dose of the compounds was increased.
(15) The derivatives, acetylcodeine, diacetylmorphine, and diacetylnalorphine were stable at room temperature for 72 hr.
(16) Comparative studies of single and multiple maternal doses indicated that diacetylmorphine (heroin) and methadone produced a four- to sixfold increase in fetal anomalies with repetitive doses whereas the percentage of malformed fetuses remained the same with hydromorphone (Dilaudid).
(17) 1 Venous blood was obtained from patients with far-advanced cancer receiving either diamorphine (diacetylmorphine, heroin) hydrochloride (65 samples) or morphine sulphate (24 samples) regularly by mouth in doses from 2.5 mg to 90 mg every 4 h. 2 Samples were obtained within 30 min of the 09.00 h drug round.
(18) Infusions with an equianalgesic dose of diacetylmorphine were well tolerated, without local or systemic side-effects, and prolonged the duration of infusion sites.
(19) By this method, d,l-methadone can be assayed in the presence of its metabolites, morphine, diacetylmorphine (heroin), codeine, and cocaine; however, amphetamine, meperidine, and quinine interfere.
(20) Morphine, diacetylmorphine and the narcotic antagonist naloxone produced a considerably weaker inhibitory effect.
Heroin
Definition:
Example Sentences:
(1) Recent research conducted by independent investigators concerning the relationship between crime and narcotic (primarily heroin) addiction has revealed a remarkable degree of consistency of findings across studies.
(2) The typology developed in two previous surveys of illicit heroin products is applicable to many of the samples studied in this work, although significant changes have occurred in the chemical profile of illicit heroin products from certain geographical regions.
(3) A procedure for detection and quantification of urinary 6-acetylmorphine (6-AM), a metabolite of heroin, is described.
(4) We have investigated the presence of fragments of the HIV genome with a new nucleic acid amplification technique (PCR or polymerase chain reaction) in lymphocytes from 33 seronegative couples with anti-HIV antibodies, most of which were heroin addicts.
(5) The Amazonian super heroine was dropped from the role less than two months later.
(6) Of 242 north Italian heroin addicts, 24 (9.9%) were HBsAg positive.
(7) Both heroin and alcohol addicts were characterized by a high frequency and magnitude of life change.
(8) But why did a pregnant heroin addict, or Nadia and the mother who put her into care, want to appear?
(9) Rates of past-year heroin abuse or dependence and heroin-related overdose deaths in the United States, 2002–2013.
(10) From Stranraer to Stornaway there is a fair chance every primary school child in the country will catch a glimpse of their heroine's gold medal at some stage, like it or not.
(11) Newborn infants delivered from mothers addicted to heroin often develop a deprivation syndrome.
(12) The results suggest that withdrawal-induced arousal may not be entirely eliminated by the heroin substitute, methadone.
(13) The efficiency of the volatilization of heroin using this procedure was studied under laboratory conditions using thin layer chromatography, gas chromatography and high pressure liquid chromatography.
(14) The first one is a renal adenocarcinoma in a heroin-abuser patient, of a type we have only found mentioned in the literature in 4 other cases.
(15) Another officer grabbing Mann by the collar and threatening his family – to arrest his wife’s “black ass” and ensure he would not see his young son grow up, Mann recalled in an interview – if he did not snitch on a heroin dealer.
(16) Plasma ACTH, cortisol, and cyclic-AMP levels of eleven heroin addicts were dertermined before and after treatment with a fast detoxification procedure using acupuncture and electrical stimulation (AES) together with the administration of limited doses of naloxone.
(17) Ian Livingstone is not all that keen on being photographed near the life-sized model of Lara Croft in his study – even though he was largely responsible for launching her on the world nearly 20 years ago, and the heroine of the Tomb Raider video games, comics and films helped to make his fortune.
(18) India is presently facing the problem of increased trafficking in drugs; heroin and hashish are supplied to the west through the subcontinent.
(19) The results suggest that heroin and PCP induce alterations in the septohippocampal cholinergic innervations and in related behavioral performance.
(20) A flawed heroine of the anti-apartheid struggle, she is unlikely to keep a low profile in the coming days or to bite her lip if she believes Mandela's memory is being betrayed.