(a.) Hard to do or to make; beset with difficulty; attended with labor, trouble, or pains; not easy; arduous.
(a.) Hard to manage or to please; not easily wrought upon; austere; stubborn; as, a difficult person.
(v. t.) To render difficult; to impede; to perplex.
Example Sentences:
(1) Virtually every developed country has some form of property tax, so the idea that valuing residential property is uniquely difficult, or that it would be widely evaded, is nonsense.
(2) Although solely nociresponsive neurons are clearly likely to fill a role in the processing and signalling of pain in the conscious central nervous system, the way in which such useful specificity could be conveyed by multireceptive neurons is difficult to appreciate.
(3) In practice, however, the necessary dosage is difficult to predict.
(4) Cor triatriatum (CT) is a rare congenital defect, surgically correctable, and sometimes difficult to diagnose by cardiac catheterization.
(5) By drawing from the pathophysiology, this article discusses a multidimensional approach to the treatment of these difficult patients.
(6) Past imaging techniques shown in the courtroom have made the conventional rules of evidence more difficult because of the different informational content and format required for presentation of these data.
(7) The way we are going to pay for that is by making the rules the same for people who go into care homes as for people who get care at their home, and by means-testing the winter fuel payment, which currently isn’t.” Hunt said the plan showed the Conservatives were capable of making difficult choices.
(8) In many cases, physicians seek to protect themselves from involvement with these difficult, highly anxious patients by making a referral to a psychiatrist.
(9) The diagnosis of variant- or Prizmetal-angina is difficult because if insufficient specificity of the tests.
(10) The detection of these antibodies is difficult owing to the lack of standardization and of specificity of the laboratory tests.
(11) It was so difficult to keep a straight face when I was filming a sauna scene with Roy Barraclough, who played the mayor of Blackpool.
(12) That is, he believes, to look at massively difficult, interlocking problems through too narrow a lens.
(13) Conversion of the active-site thiol to thiocyanate makes it more difficult to inactivate the enzyme by treatment with Cd2+.
(14) If they end up going to another club that is difficult to take.
(15) Cigarette consumption has also been greater in urban areas, but it is difficult to estimate how much of the excess it can account for.
(16) The most difficult thing I've dealt with at work is ... the terminal illness of a valued colleague.
(17) In that respect, it's difficult to see Allen's anthem as little more than same old same old, and it's probably why I ultimately feel she misses the mark.
(18) This hypothesis is difficult to substantiate with direct measurements using human subjects.
(19) Extrapolation of gestational age from early crown-rump lengths (CRLs) has been difficult because previously established tables of CRL versus gestational age have contained few measurements at less than seven to eight weeks from the first day of the last menses.
(20) Companies had made investments in certain energy sources, the president said, so change could be “uncomfortable and difficult”.
Hinder
Definition:
(a.) Of or belonging to that part or end which is in the rear, or which follows; as, the hinder part of a wagon; the hinder parts of a horse.
(a.) To keep back or behind; to prevent from starting or moving forward; to check; to retard; to obstruct; to bring to a full stop; -- often followed by from; as, an accident hindered the coach; drought hinders the growth of plants; to hinder me from going.
(a.) To prevent or embarrass; to debar; to shut out.
(v. i.) To interpose obstacles or impediments; to be a hindrance.
Example Sentences:
(1) The blocking action may have masked and hindered detection of the stimulatory action of barium in other systems.
(2) Diffusional anisotropy of water protons, induced by nonrandom, directional barriers which hinder or retard water motion, is measurable by MRI.
(3) The power of the landed elite is often cited as a major structural flaw in Pakistani politics – an imbalance that hinders education, social equality and good governance (there is no agricultural tax in Pakistan).
(4) Mapping of susceptibility is hindered by the limitations of conventional tissue typing techniques, and by strong linkage disequilibrium within this part of the genome.
(5) From these results, we presume that light induces a protein that hinders the interaction of gp70 in HM1 cells with its receptor on the NC4 cell surface and thereby inhibits the sexual process between these strains.
(6) This in vivo incorporation of tungsten was competitively hindered by molybdenum.
(7) If a prisoner is in the process of taking a programme this can hinder or even curtail their progress – many prisons don't offer certain programmes so if you are moved to a prison without a particular course you are back to square one when it comes to the crucial Parole Board assessment.
(8) From the outset the former Leicester University economics professor has made no secret of the fact this his “dysfunctional relationship” with Anastasiades and other central Bank board members had hindered his role in the post.
(9) The inhibition of Na+K+ ATPase and Mg2+ ATPase activity which may affect the release and uptake of biogenic amines in CNS, hinders the maturation of human fetal brain.
(10) The identification of patients usually refractory to outpatient treatment was hindered by the constant flux in the population base as illustrated by an 85% increase in the asthma registry over the succeeding 12-mo period.
(11) OKT4 and OKT8 monoclonal antibodies slightly hindered depolarization by CsA while OKT3, OKT11 and OKIa1 antibodies had no such effect.
(12) The Communist party and the liberal Yabloko party complained on Sunday of extensive election violations aimed at boosting United Russia's vote count, including party observers being hindered in their work.
(13) These data indicate that the basic model presented here provides a suitable vehicle for future studies into the biochemical events that may cause skeletal muscle enlargement during resistance training but, based on limited data, suggests that an increased frequency of training days may hinder muscle enlargement in this model.
(14) If this geometry was changed, a decrease in affinity was observed and if the ligand binding was sterically hindered, a spectral shift to a five-coordinated complex absorbing at 390 nm occurred.
(15) Administrative inefficiency hinders even more the appropriate utilization of resources.
(16) Thus, the product of natural processing of equine myoglobin probably has hindering structures in the regions flanking the core epitope 102-118 that interfere with presentation by I-Ak but not I-AS.
(17) Many tropical diseases cause disability and hinder the socio-economic development of the Third World countries where they rage.
(18) The difficulties encountered in casting titanium and its alloys have until recently hindered any widespread use of titanium in restorative dentistry.
(19) Warming water will make it hard for many of the reef’s corals to survive, while the acidification of the oceans will hinder the ability of remaining corals to form their skeletons.
(20) The 3-nitrocatechol-structure of nitecapone seems to hinder nitro-reduction, catechol-O-methylation, and sulfation reactions.