(1) The connection observed between the structure of DIMIT and IpTA2 on one hand and their effects on the other is in good agreement with previous studies.
(2) The serum lipid concentrations were also decreased in the obese rats in comparison with their lean littermates, especially with DIMIT.
(3) In liver mitochondrial oxidative phosphorylation, succinate cytochrome c reductase activities and nuclear RNA polymerases I and II activities were restored to normal level by DIMIT as well as by T3 treatment.
(4) The DIMIT-supplement to Tx-fetuses failed to restore these abnormal values to normal.
(5) The brief treatment in utero with high doses of T4 or of DIMIT resulted in higher neonatal mortality and the T4-treatment produce subsequent growth stunting.
(6) The thyromimetic activity of 3,5-dimethyl-3'-isopropyl-L-thyronine (DIMIT), a nonhalogenated thyroid analog, was studied in adult men using suppression of TRH-induced TSH release to assess this activity.
(7) 3,5-Dimethyl-3'-isopropyl-L-thyronine (DIMIT)-induced fetal hyperthyroid rats showed a marked accumulation of intracellular tubulin content in the cerebral cortex, hypothalamus, and cerebellum at 1 day old.
(8) The effects of an analog of thyroxine, 3,5-dimethyl-3'-isopropyl-L-thyronine (DIMIT), on fetal rat hepatocyte ultrastructure and microsomal function were investigated by using the techniques of quantitative electron microscopy and enzyme assays.
(9) Fifteen minutes prior to autopsy, animals of each group, control (C), diabetic (D), diabetic-insulin treated (DI) and diabetic-T4 followed by 3-5-Dimethyl-3'-isopropyl-L-thyronine (DIMIT) treated (DTD), received an injection of the [U-14C]-AIB SC.
(10) The metabolic effects of 3,5-dimethyl-3'-isopropyl-L-thyronine (DIMIT) on subcellular activities in brain and liver, have been compared to those of T3.
(11) At 30 days post-partum, the thyroid control system of the progeny of the T4 and DIMIT-treated animals was still abnormal with low serum T4 levels accompanied with normal serum TSH and T3 levels.
(12) In comparison with controls, DIMIT-treated livers 1) were devoid of glycogen; 2) contained smaller hepatocytes; 3) contained a greater number of hepatocytes; 4) had an increased volume density of mitochondria; and 5) had increased NADPH-cytochrome c reductase and glucose-6-phosphatase activities.
(13) There was no evidence of toxicity in patients receiving DIMIT.
(14) 3,5-Dimethyl-3'-isopropyl-L-thyronine (DIMIT) and 3,5-diiodo-3'-isopropylthyroacetic acid (IpTA2), two thyroid hormone analogs, have been tested in genetically obese Zucker rats and their lean littermates, in comparison with thyroxine (T4) and triiodothyronine (T3) for their thyromimetic activities on body weight gain and lipid levels in serum and liver.
(15) In nine men, aged 30-58 yr, the TSH increment after 500 microgram TRH iv was compared to the TSH response to TRH 24 h after oral administration of 1 mg DIMIT.
(16) DIMIT has effective thyromimetic activity in man, as shown by its significant and prolonged suppression of TSH secretion.
(17) Studies were conducted to determine if brief exposure, in utero, to high levels of T4 or to the synthetic thyromimetic agent 3,5-dimethyl-3'-isopropyl-L-thyronine (DIMIT) can produce permanent disruption of the thyroid control system in a manner analogous to the changes in the "set point" reported to occur due to neonatal T4 exposure in the "neo-T4 syndrome".
(18) All of the changes that were produced by DIMIT in the 20-day-old fetal rat, as well as smooth endoplasmic reticulum and cytochrome P-450 development, are observed in normal animals within the first 3 days after birth.
(19) DIMIT is as active as T3 in stimulation of oxidative phosphorylation and succinate cytochrome c reductase activity in liver mitochondria.
(20) On the other hand daily injection of DIMIT restored like T3 nuclear activities whereas that of brain mitochondria were unaffected.
Limit
Definition:
(v. t.) That which terminates, circumscribes, restrains, or confines; the bound, border, or edge; the utmost extent; as, the limit of a walk, of a town, of a country; the limits of human knowledge or endeavor.
(v. t.) The space or thing defined by limits.
(v. t.) That which terminates a period of time; hence, the period itself; the full time or extent.
(v. t.) A restriction; a check; a curb; a hindrance.
(v. t.) A determining feature; a distinguishing characteristic; a differentia.
(v. t.) A determinate quantity, to which a variable one continually approaches, and may differ from it by less than any given difference, but to which, under the law of variation, the variable can never become exactly equivalent.
(v. t.) To apply a limit to, or set a limit for; to terminate, circumscribe, or restrict, by a limit or limits; as, to limit the acreage of a crop; to limit the issue of paper money; to limit one's ambitions or aspirations; to limit the meaning of a word.
(v. i.) To beg, or to exercise functions, within a certain limited region; as, a limiting friar.
Example Sentences:
(1) Serum levels of both dihydralazine and metabolites were very low and particularly below the detection limit.
(2) This should not be a serious limitation to the application of the RIA in the detection of venous thrombosis.
(3) The rise of malaria despite of control measures involves several factors: the house spraying is no more accepted by a large percentage of house holders and the alternative larviciding has only a limited efficacy; the houses of American Indians have no walls to be sprayed; there is a continuous introduction of parasites by migrants.
(4) Increased infusion flow rate did not increase the limiting frequency.
(5) The extent of the infectious process was limited, however, because the life span of the cultures was not significantly shortened, the yields of infectious virus per immunofluorescent cell were at all times low, and most infected cells contained only a few well-delineated small masses of antigen, suggestive of an abortive infection.
(6) Limited biopsic retroperitoneal lymphnode dissection subsequently extended following the result of the frozen section histology.
(7) In addition, the fact that microheterogeneity may occur without limit in the mannans of the strains suggests that antibodies with unlimited diverse specificities are produced directed against these antigenic varieties as well.
(8) The specific limited trypsinolysis of bacteriophage T7 RNA polymerase (T7RP) was performed in the presence of various components of the polymerase reaction and some GTP-analogs--irreversible inhibitors of the enzyme.
(9) This postulate is supported by a limited study of the serovars present among the isolates.
(10) Breast reconstruction should not be limited to the requiring patients, but should represent, in selected cases with favourable prognosis, an integrative and complementary procedure of the treatment.
(11) As increases to the Isa allowance are based on the CPI inflation figure for the year to the previous September, the new data suggests the current Isa limit of £15,240 will remain unchanged next year.
(12) Conditions for limited digestion of the heterodimer by subtilisin, removing only the carboxyl terminus, were determined.
(13) Furthermore the limit between hearing aid fitting an cochlear implantation is discussed.
(14) Comprehensive regulations are being developed to limit human exposure to contamination in drinking water by the United States Environmental Protection Agency (EPA) under the authority of the Safe Drinking Water Act (SDWA).
(15) Direct limiting effects of hypothermia on tissue O2 delivery and muscle oxidative metabolism as well as vasoconstriction and arteriovenous shunting associated with CPB procedures are likely to be involved in the above mentioned alterations of cell metabolism.
(16) Their disadvantages - the expensive equipment and the time-consuming procedure respectively - limit their widespread use.
(17) The lower limit (LL) of CBF autoregulation was calculated by a computerized program and tested for different factors for correction of the PaCO2-induced changes in CBF.
(18) Immunochemical techniques, in particular ELISA are available for only a very limited number of NM (e.g.
(19) Only one E. coli strain, containing two plasmids that encode endo-pectate lyases, exo-pectate lyase, and endo-polygalacturonase, caused limited maceration.
(20) Initiation of the alternative pathway by the cryptococcal capsule is characterized by a lag in C3 accumulation and the appearance of a limited number of focal initiation sites which resemble those observed when the alternative pathway is activated by zymosan and nonencapsulated cryptococci.