(1) Evaluation of the in vitro activity of rokitamycin (RKM) against Chlamydia trachomatis in cycloheximide treated HeLa 229 cells and McCoy cells by comparing with five drugs including doxycycline (DOXY), minocycline (MINO), ofloxacin (OFLX), ampicillin (ABPC) and erythromycin (EM) with regard to assaying minimal inhibitory concentrations (MICs), minimal lethal concentrations (MLCs), and by yield reduction assays: 1) direct treatment of Chlamydial organisms with various concentrations of antibiotics before inoculation, 2) pre-treatment of host cell (HeLa 229) with the antibiotics before they are infected and 3) treatment of already infected cultures (48 hrs after infection) with antibiotics.
(2) The following antibiotics were evaluated; ampicillin (ABPC), piperacillin (PIPC), cefotaxime (CTX), cefoperazone (CPZ), ceftizoxime (CZX), cefmenoxime (CMX), latamoxef (LMOX), tetracycline (TC), doxycycline (DOXY), minocycline (MINO), chloramphenicol (CP) and erythromycin (EM).
(3) Degenerative cartilage lesions on the medial trochlear ridge, superficial fibrillation of the medial tibial plateau, and osteophytosis were, however, unaffected by doxy treatment.
(4) In conclusion, DOXY was thought to be useful and safe drug in the treatment of nongonococcal urethritis by C. trachomatis.
(5) In vitro studies have indicated that levels of neutral metalloproteinases in osteoarthritic (OA) cartilage are elevated and that doxycycline (doxy) inhibits collagenolytic and gelatinolytic activity in extracts of OA cartilage.
(6) Six dogs received doxy orally from the day after ACL transection until they were killed 8 weeks later; the other 6 served as untreated OA controls.
(7) Thirty male patients with nongonococcal urethritis and 7 female patients nongonococcal cervicitis were treated with 200 mg doxycycline (DOXY) daily over a period of 7 days.
(8) 3) After treatments with DOXY for cases of positive IgA titers in prostatic secretion, IgA titers of those cases were decreased and inflammations of prostate were cured.
(9) The purpose of the present study was to test the effect of oral doxy administration on the severity of cartilage degeneration in OA.
(10) It remains to be determined whether administration of doxy after OA changes have developed is also effective.
(11) The MIC90 of OFLX was equal to that of DOXY and 4- to 16-fold smaller than the values of the other 3 antibiotics.
(12) Doxycycline (DOXY) was administered to 45 male patients with nongonococcal urethritis.
(13) In vitro activities of ofloxacin (OFLX), a new quinolone derivative, against 29 strains of Mycoplasma gallisepticum was compared with those of 4 commonly used antimicrobial agents, doxycycline (DOXY), tylosin (TS), spectinomycin (SPCM) and thiamphenicol (TP).
(14) Prophylactic administration of doxy markedly reduced the severity of OA in weight-bearing regions of the medial femoral condyle.
(15) A comparison of the O2- yields from the tetracyclines examined showed the trend chlortetracycline (CTC) greater than oxytetracycline (OXY) greater than demeclocycline (DEM) much greater than (doxycycline (DOXY) = tetracycline (TC) = minocycline (MINO) = 0).
(16) Low concentrations of 16-DOXY L-Stearate dramatically broaden the 13C-NMR resonances of deoxycholate carbons 19, 18 and 7 in particular, while 5-DOXY L-Stearate exerts much less specific effects.
(17) C. trachomatis positive rate of male NGU after treatment of DOXY for 3 days, 7 days and 14 days, was 83%, 17% and 0%, respectively.
(18) Because of continuing fever, mefloquin (Lariam) and doxy-cycline (Vibramycin) were also administered.
(19) DOXY was given in an oral dose of 100 mg twice daily for 4 to 19 days.
(20) No side effect related to dosing of DOXY developed.
Opinion
Definition:
(n.) That which is opined; a notion or conviction founded on probable evidence; belief stronger than impression, less strong than positive knowledge; settled judgment in regard to any point of knowledge or action.
(n.) The judgment or sentiment which the mind forms of persons or things; estimation.
(n.) Favorable estimation; hence, consideration; reputation; fame; public sentiment or esteem.
(n.) Obstinacy in holding to one's belief or impression; opiniativeness; conceitedness.
(n.) The formal decision, or expression of views, of a judge, an umpire, a counselor, or other party officially called upon to consider and decide upon a matter or point submitted.
(v. t.) To opine.
Example Sentences:
(1) Without medication atypical ventricular tachycardia develops, in the author's opinion, most probably when bradycardia has persisted for a prolonged period.
(2) For some time now, public opinion polls have revealed Americans' strong preference to live in comparatively small cities, towns, and rural areas rather than in large cities.
(3) One thing seems to be noteworthy in their opinion: the bacterial resistance of the germs isolated from the urine is bigger than the one of the germs isolated from the respiratory apparatus.
(4) In self-opinions on own appearance the children mentioned teeth as a feature which they would like to change as first.
(5) True, Syria subsequently disarmed itself of chemical weapons, but this was after the climbdown on bombing had shown western public opinion had no appetite for another war of choice.
(6) In our opinion, a carcinologically "malignant" metastatic myxoma remains a questionable pathological entity.
(7) It can feel as though an official opinion has been issued.
(8) Although individual IRB chairpersons and oncology investigators may have important differences of opinion concerning the ethics of phase I trials, these disagreements do not represent a widespread area of ethical conflict in clinical research.
(9) However, controversy and differing opinions about the disbursement of contraceptives remains.
(10) In his notorious 1835 Minute on Education , Lord Macaulay articulated the classic reason for teaching English, but only to a small minority of Indians: “We must do our best to form a class who may be interpreters between us and the millions whom we govern; a class of persons, Indians in blood and colour, but English in taste, in opinions, in morals and in intellect.” The language was taught to a few to serve as intermediaries between the rulers and the ruled.
(11) The authors are of the opinion that the processes occurring in the neighbourhood of the traumatic skin wound can be influenced and that regeneration can be regulated.
(12) In this way, we tried to find out how the patients experience the treatment and stay on the Unit, what is most helpful in solving their problems and what are, in their opinion, the direct gains of hospitalization.
(13) Twellman has steadily grown in confidence as he settles into his role, though whether as a player or as an advocate he was never shy about voicing his opinions.
(14) He told FA.com: “In my opinion, we were worthy winners.
(15) But under Comey’s FBI, the agency has continued to disregard the justice department’s legal opinion, and to this day, demands tech companies hand it all sorts of data under due-process free National Security Letters.
(16) The current opinion, based on different clinical tests, is that parasympathetic impairment occurs earlier in autonomic dysfunctions.
(17) In our opinion, this is the first case of that condition reported in this country.
(18) Piccoli followed that up with an opinion piece for Fairfax Media on Thursday in which said the SES model never applied to public schools and was not properly targeted to student needs.
(19) After presenting some incontestable facts of CSF-physiology the actual and quite controversial opinions on ventricular and extraventricular sources of CSF as well as the mechanism of CSF-absorption are discussed.
(20) Mark Rasch, a cyber crime expert quoted by the FT, meanwhile said recent events have been “a serious and devastating attack to [Sony’s] reputation and image”, and his opinion is played out by a new YouGov poll into the public perception of Sony’s brand.