(a.) Acting rapidly and violently; efficacious; powerful; -- opposed to bland; as, drastic purgatives.
(n.) A violent purgative. See Cathartic.
Example Sentences:
(1) During the first three weeks of adaptation drastic changes in the parameter were seen.
(2) The differentiation between the various modes of involvement is essential as some of them may be confused with recurrence and the clinician might resort to unnecessary drastic measures like enucleation.
(3) Survival rates depend on age: 5 years survival rate of patients up to 65 years was 8,1% (59 of 729) and fell drastically in patients of 65+ years (28 of 1109 = 2,5%).
(4) While visitors amble freely around the newly refurbished inside – the Pierhead is sure and steadfast in its role outside as the drastic red building, emblazoning the landscape of Cardiff Bay in all its regal beauty.
(5) Optic chiasm transection drastically diminished this ability, callosal section had little effect and combined lesions of these two structures abolished stereoperception.
(6) The observed drastic interstrain differences in dopamine receptor sensitivity demonstrate the essential role of genotype in the effects of dopaminergic drugs.
(7) Treatment of Xenopus laevis membranes with the 2',3'-dialdehyde of GTP (dial GTP) drastically inhibits their adenylyl cyclase activity.
(8) Ivermectin treatment of all cattle on a badly infected farm failed to interrupt the transmission of P. bovicola, even though ovipositional blood spots were drastically reduced in numbers for an entire summer season following treatment.
(9) The number of DAB positive organelles per surface area decreased steadily with culture age, and significantly on day 2 (p less than 0.01) to become drastically low on day 5 and negligible on day 7.
(10) However, treatment of intact worms drastically affected the integrity of the membrane.
(11) Treatment with glucocorticosteroids has drastically improved the prognosis.
(12) Only a drastic osmotic shock in distillated water as a mean to disrupt mitochondrial membrane was found to strongly increase the actual rate of the rotenone-sensitive activity.
(13) Such a drastic measure in an impossibly short timeframe would deprive generations of refugees of any choices for their future,” said Charles Gaudry, MSF’s head of mission in Kenya.
(14) In the deforming osteo-arthrosis (150 observations) in the synovial sheath there were usually noted drastic sclerosis and atrophy of organ-specific structures, impairmement of the production of the synovial fluid, and dystrophic falling into fibers of the articular cartilage with intensive proliferation of the cartilage cells.
(15) This was primarily due to the drastic decrease with age in excretion of bis-digitoxoside.
(16) The velocity of darkness adaptation was drastically changed in patients with chronic alcoholism but it was also reversible.
(17) The combined effects lead to a drastic antimutagenic effect, the molecular mechanism of which is given by these changes in mutagen-metabolizing enzymes.
(18) Decreasing the water concentration in the reaction medium by adding methanol at 0 degrees C drastically reduces the rate of racemization without affecting the rate of transamination.
(19) The factor production during a certain period of the development of lines is drastically increased by radiation.
(20) Excretion of zinc and especially of silicon through the kidneys and intestine drastically grew on the day of the contest.
Severe
Definition:
(superl.) Serious in feeeling or manner; sedate; grave; austere; not light, lively, or cheerful.
(superl.) Very strict in judgment, discipline, or government; harsh; not mild or indulgent; rigorous; as, severe criticism; severe punishment.
(superl.) Rigidly methodical, or adherent to rule or principle; exactly conformed to a standard; not allowing or employing unneccessary ornament, amplification, etc.; strict; -- said of style, argument, etc.
(superl.) Sharp; afflictive; distressing; violent; extreme; as, severe pain, anguish, fortune; severe cold.
(superl.) Difficult to be endured; exact; critical; rigorous; as, a severe test.
Example Sentences:
(1) We used the polymerase chain reaction (PCR) to amplify the breakpoint area of alpha-thalassemia-1 of Southeast Asia type and several parts of the alpha-globin gene cluster to make a differential diagnosis between alpha-thalassemia-1 and Hb Bart's hydrops fetalis.
(2) The newborn with critical AS typically presents with severe cardiac failure and the infant with moderate failure, whereas children may be asymptomatic.
(3) The low affinity of several N1-alkylpyrroleethylamines suggests that the benzene portion of the alpha-methyltryptamines is necessary for significant affinity.
(4) The main clinical features pertaining to the concept of the "psycho-organic syndrome" (POS) were investigated in a sample of children who suffered from severe craniocerebral trauma.
(5) The rise of malaria despite of control measures involves several factors: the house spraying is no more accepted by a large percentage of house holders and the alternative larviciding has only a limited efficacy; the houses of American Indians have no walls to be sprayed; there is a continuous introduction of parasites by migrants.
(6) Collins said she asked Sullivan several questions, including who the women were.
(7) Single-case experimental designs are presented and discussed from several points of view: Historical antecedents, assessment of the dependent variable, internal and external validity and pre-experimental vs experimental single-case designs.
(8) During and after the infusion of 5HTP, none of the patients showed an increase in anxiety or depressive symptoms, despite the presence of severe side effects.
(9) Histological studies showed that the resulting pancreatitis was usually mild to moderate, being severe only in association with sepsis.
(10) An “out” vote would severely disrupt our lives, in an economic sense and a private sense.
(11) No consistent relationship could be found between the time interval from SAH to operation and the severity of vasospasm.
(12) Also we found that the lipid deposition in the glomeruli of patients with Alagille syndrome is related to an abnormal lipid metabolism, which is the consequence of severe cholestasis.
(13) Sixteen patients in whom schizophrenia was initially diagnosed and who were treated with fluphenazine enanthate or decanoate developed severe depression for a short period after the injection.
(14) Concentrations of several gastrointestinal hormonal peptides were measured in lymph from the cisterna chyli and in arterial plasma; in healthy, conscious pigs during ingestion of a meal.
(15) In addition to the changes associated with blood group A, we also found a decrease in sugar content, alterations in other antigens, and changes in the levels of several glycosyltransferases in cancerous tissues.
(16) Based on several previous studies, which demonstrated that sorbitol accumulation in human red blood cells (RBCs) was a function of ambient glucose concentrations, either in vitro or in vivo, our investigations were conducted to determine if RBC sorbitol accumulation would correlate with sorbitol accumulation in lens and nerve tissue of diabetic rats; the effect of sorbinil in reducing sorbitol levels in lens and nerve tissue of diabetic rats would be reflected by changes in RBC sorbitol; and sorbinil would reduce RBC sorbitol in diabetic man.
(17) The severity and site of hypertrophy is important in determining the clinical picture and the natural history of hypertrophic cardiomyopathy (HCM).
(18) After a discussion of the therapeutic relationship, several coping strategies which have been used successfully by many women are described and therapeutic applications are offered.
(19) To clarify the functional roles of His40, Glu58, and His92, we analyzed the consequences of several amino acid substitutions (His40Ala, His40Lys, His40Asp, Glu58Ala, Glu58Gln, and His92Gln) on the kinetics of GpC transesterification.
(20) Moreover, in DCVC-treated cells the mitochondria could not be stained with rhodamine-123, indicating severe mitochondrial damage and loss of membrane potential.