(n.) Any animal, vegetable, or mineral substance used in the composition of medicines; any stuff used in dyeing or in chemical operations.
(n.) Any commodity that lies on hand, or is not salable; an article of slow sale, or in no demand.
(v. i.) To prescribe or administer drugs or medicines.
(v. t.) To affect or season with drugs or ingredients; esp., to stupefy by a narcotic drug. Also Fig.
(v. t.) To tincture with something offensive or injurious.
(v. t.) To dose to excess with, or as with, drugs.
Example Sentences:
(1) Previous use of the drug is found in more than 50 per cent of the patients, and it was often followed by a neglected side-effect.
(2) Disease stabilisation was associated with prolonged periods of comparatively high plasma levels of drug, which appeared to be determined primarily by reduced drug clearance.
(3) The significance of minor increases in the serum creatinine level must be recognized, so that modifications of drug therapy can be made and correction of possibly life-threatening electrolyte imbalances can be undertaken.
(4) We have investigated the effect of methimazole (MMI) on cell-mediated immunity and ascertained the mechanisms of immunosuppression produced by the drug.
(5) Theophylline kinetics, as an in vivo probe for the potentially toxic cytochrome P-450I pathway of drug metabolism, were studied in 11 healthy volunteers and 11 patients with calcific chronic pancreatitis at Madras, South India.
(6) However, medicines have an important part to play, and it is now generally agreed that for the very poor populations medicines should be restricted to those on an 'essential drugs list' and should be made available as cheaply as possible.
(7) The ability of azelastine to influence antigen-induced contractile responses (Schultz-Dale phenomenon) in isolated tracheal segments of the guinea-pig was investigated and compared with selected antiallergic drugs and inhibitors of arachidonic acid metabolism.
(8) The LD50 of the following metal-binding chelating drugs, EDTA, diethylenetriaminepentaacetic acid (DTPA), hydroxyethylenediaminetriacetic acid (HEDTA), cyclohexanediaminotetraacetic acid (CDTA) and triethylenetetraminehexaacetic acid (TTHA) was evaluated in terms of mortality in rats after intraperitoneal administration and was found to be in the order: CDTA greater than EDTA greater than DTPA greater than TTHA greater than HEDTA.
(9) Meanwhile the efficiency of muscarinic antagonists in inhibition of tremor reaction induced by arecoline administration is associated with interaction between the drugs and the M2-subtype.
(10) Some of those drugs are able to stimulate the macrophages, even in an aspecific way, via the gut associated lymphatic tissue (GALT), that is in connection with the bronchial associated lymphatic tissue (BALT).
(11) The 14C-aminopyrine breath test was used to measure liver function in 14 normal subjects, 16 patients with alcoholic cirrhosis, 14 alcoholics without cirrhosis, and 29 patients taking a variety of drugs.
(12) The results of the evaluation confirm that most problems seen by first level medical personnel in developing countries are simple, repetitive, and treatable at home or by a paramedical worker with a few safe, essential drugs, thus avoiding unnecessary visits to a doctor.
(13) Acquired drug resistance to INH, RMP, and EMB can be demonstrated in M. kansasii, and SMX in combination with other agents chosen on the basis of MIC determinations are effective in the treatment of disease caused by RMP-resistant M. kansasii.
(14) Further development of drug formulary concept was discussed, primarily for the drugs paid by the Health Insurance, as well as the unsatisfactory ADR reporting in Yugoslavia.
(15) Senator Bernie Sanders of Vermont, who is also seeking the Democratic presidential nomination, recently proposed a bill that would ease the financial burden of prescription drugs on elderly Americans by allowing Medicare, the national social health insurance program, to negotiate with the pharmaceutical companies to keep prices down.
(16) The authors empirically studied the self-medication hypothesis of drug abuse by examining drug effects and motivation for drug use in 494 hospitalized drug abusers.
(17) Inadequate treatment, caused by a lack of drugs and poorly trained medical attendants, is also a major problem.
(18) To investigate the relationship between Helicobacter pylori infection and nonsteroidal anti-inflammatory drug (NSAID) intolerance and the effect of gold use on the seroprevalence of H. pylori.
(19) A remarkable deterioration of prognosis with increasing age rises the question whether treatment with cytotoxic drugs should be tried in patients more than 60 years old.
(20) It was concluded that metoclopramide and dexamethasone showed an excellent antiemetic effect on acute drug-induced emesis, as well as on delayed emesis, induced by cisplatin.
Spiked
Definition:
(imp. & p. p.) of Spike
(a.) Furnished or set with spikes, as corn; fastened with spikes; stopped with spikes.
Example Sentences:
(1) It was tested for recovery and separation from other selenium moieties present in urine using both in vivo-labeled rat urine and human urine spiked with unlabeled TMSe.
(2) The pons, on the other hand, has a bioelectrical activity of its own during PS, i.e., the ponto-geniculo-occipital spikes (PGO).
(3) The spikes likely correspond to VP3, a hemagglutinin, while the rest of the mass density in the outer shell represents 780 molecules of VP7, a neutralization antigen.
(4) In this series there were 45 patients (40%) with independent focal interictal EEG epileptic abnormalities over frontobasal cortex (with or without independent spiking over interomedial temporal region).
(5) It was shown that gradual recovery of spike wave patterns occurred from initial water swallowing to successive dry swalllowing.
(6) One might expect that a similar news spike and rebounding of support for stricter gun control can happen, given President Obama's new push.
(7) By this action, oxytocin is believed to increase the probability of successful regenerative spikes and thereby initiate electrical activity in quiescent preparations, increase the frequency of burst discharges, the number of spikes in each burst, and the amplitude of spikes in individual cells.
(8) The differentiated neuroblastoma cell possesses characteristics of an electrically excitable cell and can generate propagated potential spikes in which Ca2+ is the inward charge carrier.
(9) Jane's life clearly still has a massive Spike-shaped hole in it.
(10) Our hypothesis is that phase unlocking may be one of the induction mechanisms of spike-burst activity.
(11) The threshold of epileptic spiking varied inversely with the area of cortical damage inflicted by the electrode.
(12) In some ways, the Gandolfini performance that his fans may savour most is his voice work in Spike Jonze's Where the Wild Things Are (2009), the cult screen version of Maurice Sendak 's picture book classic – he voiced Carol, one of the wild things, an untamed, foul-mouthed figure.
(13) The best understood fusion mechanism is that of influenza virus, for which sequences involved in pH-dependent fusion can be correlated with the crystallographic structure of the spike protein.
(14) Single shocks applied to medullary pressor sites evoked a train of spikes in the interneurons.
(15) Many subjects have a negative spike in the beginning of a saccade in electro-oculographic signals.
(16) This enhancement of laminin synthesis corresponds to the mesangial expansion and to the development of laminin-containing spike formations of the glomerular basement membrane at week 8.
(17) A train of conditioning stimuli to either of the midbrain nuclei produced inhibition of evoked population spikes recorded in the CA1 pyramidal cell layer of the hippocampus.
(18) The brief (3 ms) afterhyperpolarizations that followed such spikes were blocked by intracellular injections of Cs+ or by bath applications of tetraethylammonium.
(19) They discharged one or two spikes only at the beginning of depolarizing current pulses.
(20) An increase followed by a decrease in the number of spikes per burst and a reduction in the peak activity were observed.