(1) This suggests that there was a deterioration of the vasoconstrictor response and indicated a possible effect of heat at the receptor or effector level.
(2) Three effector: target ratios (6.2:1, 25:1, and 50:1) were studied in quadruplicate using 3, 4 and 5-h incubations.
(3) The results support the notion that mediator lymphocytes circulate in tumor immunized rats in a noncytotoxic state, specifically recognize tumor cells at a challenge site, and mediate induction of effector cells locally.
(4) The presence of a previously unreported dipeptide transport mechanism within blood leukocytes and the selective enrichment of the granule enzyme, DPPI, within cytotoxic effector cells of lymphoid or myeloid lineage appear to afford a unique mechanism for the targeting of immunotherapeutic reagents composed of simple dipeptide esters or amides.
(5) The isolated LGL were highly cytotoxic against YAC-1 lymphoma cells and this cytolytic activity was blocked by treatment of the effector cells with an antibody against natural killer cells (anti-asialo GM1).
(6) Interestingly, different mechanisms of nucleated and non-nucleated TC directed lysis by CD4+ effectors were implied by distinct patterns of sensitivity to cholera toxin (CT) and cyclosporin A (CsA).
(7) These killer cells could lyse a wide range of syngeneic and allogeneic lymphoid tumour cell lines in vitro, and it was found that cell suspensions from nude mice were always significantly more active than those from normal mice, and that the most active effector population was a polymorph-enriched peritoneal-exudate cell suspension.
(8) We speculate that intestinal injury may also induce or perpetuate arthritis by systemic distribution of inflammatory mediators produced by intestinal immune effector cells.
(9) Effector cells capable of mediating cytotoxicity in each assay were defined by testing the cytotoxic function of lymphocyte subpopulations isolated from two representative patients with each disease using techniques of immunoabsorbent affinity chromatography and Fc receptor binding to antigen-antibody complexes.
(10) Thus, monocytes may play a dual role, not only as effector cells, but also as cells that collaborate with T cells after OKT3 MoAb stimulation so as to produce PCA.
(11) Furthermore, effector TH cells within the two compartments exert differential effector activities: splenic effector TH cells induce B cells to both proliferation and maturation, while thymic effector TH cells are defective in activating B-cell maturation.
(12) Our results suggest that NCAM, in the presence of other AM, may have a supportive role in adhesion of leukaemic targets to LAK effectors.
(13) The cytolytic activity of peritoneal SEA reactive effector cells was confined to the TCR alpha beta+ CD4- CD8+ CD45RC- cell population.
(14) FBP was bound with greater frequency and intensity to 3-day oil-elicited peritoneal macrophages which are responsive to migration inhibition by FBP and migration inhibitory factor (MIF) than to resident or 7-day inflammatory macrophages which are unresponsive to activation by the same effectors.
(15) Pyocyanine did not interfere with interleukin 2 synthesis, nor did it affect the lytic stage of cytotoxic effector T cells.
(16) Such data show that effector cells which kill antibody-coated target cells may be of T cell nature.
(17) The immune system has evolved to protect an organism from the pathogens that invade it but the effector mechanisms involved in mediating this protection are potentially lethal to the host itself.
(18) Chimeric oligodeoxynucleotides, comprised of internal phosphodiester and terminal methylphosphonodiester sections, possess many beneficial characteristics as antisense effectors.
(19) The development of T cells from stem (progenitor) cells to effector cells results from a two-wave process of proliferation and differentiation.
(20) Because previous work has shown that radioisotope release from parasites may be nonspecific, separate experiments were performed to determine the cytotoxicity of LAK cells against antibody-coated trophozoites by using ethidium bromide-acridine orange staining to assess effector cell damage.
Effectuate
Definition:
(v. t.) To bring to pass; to effect; to achieve; to accomplish; to fulfill.
Example Sentences:
(1) It postulated that this competition is effectuated through the repression of the B cell function by the T1 lymphocyte killer effectors of the DH committed to the same antigen against which the "blasts" or the plasmoblasts (subsequently transformed into MC) were produced.
(2) The anatomopathological exam which was effectuated for 33 patients hes shown Bowen's disease for 14 cases, spinocellular carcinoma for 15 patients and basocellular for 3 patients.
(3) In shock patients the hemodilution achieved with red cell free primary volume substitutes is an effective treatment for shock-induced microcirculatory disorders; furthermore, intentional hemodilution is the most effectual hemorheological therapy for the treatment of ischemic disease.
(4) At low cell density hypoxia effectuated increase in hyaluronic acid and decrease in chondroitin sulphate and dermatan sulphate, respectively.
(5) Since microclimate is variable in the stable, it ought to be measured with the purpose of possibly effectuating a correction.
(6) Today, my colleagues seem to have fallen prey to the misguided notion that the intent of the framers of the United States constitution can be effectuated only by cleaving to the legislative will and ignoring and demonizing an independent judiciary,” he wrote.
(7) In its turn, interaction is subdivided in three classes (uni-effectual, bis-ineffectual, bis-effectual) in the last of which is placed the most relevant of the interactions, that is synergism, subclassified, at its turn, as additive, super and infra-additive.
(8) It is suggested that xerophthalmia screening be made an essential component of routine medical check-up in schools with XN (night blindness with or without conjunctival xerosis) and XIB (Bitot's spots) used as criterion for screening to effectuate early detection and treatment of xerophthalmia.
(9) The results of this study have proved that initial treatment is effectual only on pockets measuring less than 4 mm to periodontal probing.
(10) Effectual diagnosis is totally dependent on prompt detection of an asymptomatic, irreducible scrotal swelling that fails to transilluminate.
(11) According to the underlying paradigm, arousal effectuates slower reaction times and depressed EMG activity after an unexpected preparatory signal on a visuospatial choice-reaction task, whereas activation effectuates faster reaction times and elevated EMG activity after an unexpected preparatory signal on a semantic choice-reaction task.
(12) Covalent binding of model enzymes, chymotrypsin and trypsin, to elastic polymer supports, nylon and viscose (cellulose) fibers, human hair, methacrylate rubber, has been effectuated.
(13) It is shown that the diagnosis of ocular toxoplasma must be effectuated just corroborating the clinic data with the positive serology.
(14) The physiological handling of ionized calcium (Ca2+), which serves multiple roles as an extracellular signal, a second messenger, and an activator interacting directly with myofilaments to effectuate contractile responses, referred to as Ca2+ signalling processes, represents an integral part of a more complicated membrane transduction mechanism.
(15) The authors describe a patient with hemiparesis who developed the syndrome of irreversible lithium-effectuated neurotoxicity (SILENT) while being treated with lithium for a manic episode.
(16) It is concluded that oxygenation and adding DBcAMP to CCS are effectual for the myocardial metabolism and protect the myocardial damage during cardiac arrest.
(17) Tests effectuated on 100 patients' teeth show this therapy efficaciousness.
(18) Intraluminal irradiation is an attractive, effectual therapeutic alternative, especially in patients with advanced local or distant disease unlikely to tolerate 5 to 7 weeks of external beam therapy.
(19) He told ABC radio: “There was a committee that was not very effectual and the chairman of the committee is now the departmental medical officer who is providing advice in a more sustained way.” The letter from Bowles reveals that the current chair of IHAG, Dr Paul Alexander has been appointed as the independent health advisor to the department in a streamlined and scaled back health advisory formation.
(20) It has been confirmed that chemoprophylactic treatments may control opportunistic endogenous mycoses effectually.