(n.) Originally, the art of managing engines; in its modern and extended sense, the art and science by which the mechanical properties of matter are made useful to man in structures and machines; the occupation and work of an engineer.
Example Sentences:
(1) Michael Schumacher’s manager hopes F1 champion ‘will be here again one day’ Read more Last year, Red Bull were frustrated by Mercedes, Ferrari and Honda as they desperately looked for a new engine supplier.
(2) The idea that 80% of an engineer's time is spent on the day job and 20% pursuing a personal project is a mathematician's solution to innovation, Brin says.
(3) Two EGZ-derived proteins were engineered in which either His98 or Glu133 amino acid was converted to an Ala residue.
(4) Liu was a driving force behind the modernisation of China's rail system, a project that included building 10,000 miles of high-speed rail track by 2020 – with a budget of £170bn, one of the most expensive engineering feats in recent history.
(5) Scott was born in North Shields, Tyne and Wear, the youngest of the three sons of Colonel Francis Percy Scott, who served in the Royal Engineers, and his wife, Elizabeth.
(6) Terry Waite Chair, Benedict Birnberg Deputy chair, Antonio Ferrara CEO The Prisons Video Trust • If I want to build a bridge, I call in a firm of civil engineers who specialise in bridge-building.
(7) Some 10 fire engines remained on the scene after rushing there to extinguish the many blazes caused by the crash.
(8) Engineering and physiologic aspects of growth and production processes associated with encapsulated cells, mostly of anchorage-independent type, are reviewed.
(9) Aircraft pilots Facebook Twitter Pinterest ‘Getting paid to have your head in the clouds.’ Photograph: CTC Wings Includes: Flight engineers and flying instructors Average pay before tax: £90,146 Pay range: £66,178 (25th percentile) to £97,598 (60th percentile).
(10) Based on the principles of adaptational mutations and genetic exchange of catabolic activities, it becomes possible to select and engineer microorganisms that are suitable for the degradation of recalcitrant compounds.
(11) The footballer said the noise of the engine was too loud to hear if Cameron snored but his night "wasn't the best".
(12) Top 10 Arpad Cseh Senior investment director, UBS Alice La Trobe Weston Executive director, head of European credit research, MSIM Morgan Stanley Katie Garrett Executive director, senior engineer, Goldman Sachs Alix Ainsley, Charlotte Cherry H R director, group operations (job share), Lloyds Banking Group Matt Dawson Director for business development, The Instant Group Angela Kitching, Hannah Pearce Head of external affairs (job share), Age UK Morwen Williams Head of newsgathering operations, BBC Georgina Faulkner Head of Sky multisports, Sky Maggie Stilwell Managing partner for talent, UK & Ireland, EY Sarah Moore Partner, PwC
(13) In what appeared to be pointed criticism of increasingly firm rhetoric from Cameron on multinational tax engineering, Carr insisted tax avoidance "cannot be about morality – there are no absolutes".
(14) If we were to have a plebiscite before the end of the year, and you were to reverse-engineer that, it would make interesting speculation about the timing of an election.” Abetz said in January he would need to see whether a plebiscite was “above board or whether the question is stacked” before deciding to heed any result in favour of marriage equality.
(15) "What this proves is that the way Bowie engineered his comeback was a stroke of genius," said music writer Simon Price.
(16) The carbohydrate structures of a genetically engineered human tissue plasminogen activator variant bearing a single N-glycosylation site at Asn 448 are reported.
(17) Senior executives at Network Rail are likely to be summoned to Westminster to explain the engineering overruns that caused chaos for Christmas travellers over the weekend.
(18) It will pump nothing more than water into the air, but it will allow climate scientists and engineers to gauge the engineering feasibility of the plan.
(19) Techniques of genetic engineering, homologous recombination, and gene transfection make it feasible to produce antigen-binding molecules with widely varying structures.
(20) This test was applied to hGH extracts produced genetically engineered E. coli K12 and a good correlation was found with the LAL test.
Groove
Definition:
(n.) A furrow, channel, or long hollow, such as may be formed by cutting, molding, grinding, the wearing force of flowing water, or constant travel; a depressed way; a worn path; a rut.
(n.) Hence: The habitual course of life, work, or affairs; fixed routine.
(n.) A shaft or excavation.
(v. t.) To cut a groove or channel in; to form into channels or grooves; to furrow.
Example Sentences:
(1) The ligands bind at discrete sites in the minor groove of DNA, and analysis on DNA sequencing gels show pronounced protection at the ligand binding sites, as well as more generalized protection.
(2) Recent reports have indicated the usefulness of nuclear grooves (clefts or notches) as an additional criterion for the diagnosis of papillary thyroid carcinoma in fine needle aspirates; most of these studies were carried out on alcohol-fixed material stained with the Papanicolaou stain or with hematoxylin and eosin, which yield good nuclear details.
(3) Intermolecular contacts occur in both oligomers in the minor groove: in the B form through twisted guanine-guanine hydrogen bonding, and in the Z form through base-base stacking and the water network.
(4) The nogalose and aminoglucose sugars lie in the minor and major grooves, respectively, of the distorted B-DNA double helix.
(5) The AFB1 moiety is face-stacked in the major groove with its long axis approximately perpendicular to the helix axis.
(6) These results strongly indicate that metallobleomycin binds in the minor groove of B-DNA and that the 2-amino group of guanine adjacent to the 5' side of the cleaved pyrimidine base is one key element of the specific 5' G-C or G-T recognition by the bleomycin-metal complex.
(7) As a basis for the discussion a possible structure for the DNA complex of the phenylated neutral red is considered in which the extra phenyl ring at N-5 of the phenazinium system, protrudes into the large groove of the DNA helix while the tricyclic part of the ligand is inserted between the DNA base-pairs.
(8) A high intensity of the reactions was observed in certain cells of the neural groove in 24-hours' embryos and in the neural tube of 48-hours' embryos.
(9) Recent STM studies of calf thymus DNA and poly(rA).poly(rU) have shown that the helical pitch and periodic alternation of major and minor grooves can be visualized and reliably measured.
(10) In the absence of boxes or grooves, pins markedly enhanced both retention and resistance.
(11) Therefore in artificial knee replacement a lateral tilt of the patella sliding groove should not be propagated as 'physiological'.
(12) Many antitumor drugs, and many carcinogens, act by binding within the minor groove of double-helical DNA, interfering with both replication and transcription.
(13) This instrument, a modification of a corneal trephine, provides a neat, smooth groove of adjustable depth.
(14) and the fluid ejected from the ejaculatory groove region (about 0.2 ml.).
(15) 3) The significance of minor groove Mtase-DNA interactions to specificity is confirmed.
(16) (v) The bis-benzimidazole drug Hoechst-33258, which binds in the minor groove of B-DNA, exhibits very little fluorescence in the presence of the ps hairpins but a normal, enhanced emission with the aps oligonucleotides.
(17) We have studied the time-resolved and the steady-state fluorescence of the DNA groove binders 4',6-diamidino-2-phenylindole (DAPI) and Hoechst 33258 with the double stranded DNAs poly(dA-dU) and poly(dI-dC) and their halogenated analogs, poly(dA-I5dU) and poly(dI-Br5dC).
(18) The complexation-induced chemical shifts and NOE cross peaks in the NOESY map of the 1:1 complex of lexitropsin (1) and d-[CGCAATTGCG]2 reveal that the thiazole ring of the lexitropsin (1) intercalates between dA4.A5 bases and the rest of the ligand resides in the minor groove of the AT rich core of decamer, thus occupying the 5'-AATT sequence on the DNA.
(19) All cases had true hypertelorism and a median nasal groove with absence of the nasal tip.
(20) Distamycin, Hoechst 33258, and DAPI were used as agents capable of AT-specific binding in the minor groove of DNA while producing no profound long-range distortion of DNA structure.