(1) At saturating concentrations of ER, plasmids bearing one, two, and four EREs in tandem bound approximately one, two, and four dimeric ER molecules, respectively.
(2) Interestingly, each of these fragments had a perfect palindromic estrogen responsive element (ERE) (GGT-CANNNTGACC).
(3) These data suggest that flanking DNA sequences may exert a significant effect on the activity of EREs as hormone-dependent transcription activators.
(4) In 11 spontaneously breathing patients with chronic obstructive pulmonary disease (COPD) in acute ventilatory failure, we measured the total inspiratory (WItot) and total resistive (WI + Eres) work rate of breathing, together with lung mechanics (dynamic pulmonary elastance and inspiratory and expiratory pulmonary flow resistance).
(5) This element binds to the estrogen receptor in vitro as assessed by gel retardation assay similar to the vitellogenin gene ERE.
(6) The two polypeptides are different as judged by peptide mapping, and only the 85-kDa polypeptide can be cross-linked to the bromodeoxyuridine-substituted synthetic ERE by UV irradiation.
(7) Two methods have been suggested for the calculation of pHapp and the loss of activity on particle preparation, these methods are based on the use of the ERE in conjunction with experimental data.
(8) These results suggest that the ability of ER and TR to functionally discriminate between an ERE and a TRE is a result of dimerization of their DBDs.
(9) The presence of the biologically active hER is confirmed in co-injection experiments, in which HEO is co-introduced with a CAT reporter gene under the control of a vitellogenin promoter containing or lacking the ERE.
(10) Gene transfer experiments using estrogen-responsive cells have shown that the 13 bp perfect palindromic element GGTCACTGTGACC found upstream of the Xenopus laevis vitellogenin gene A2 promoter mediates hormonal stimulation and thus, was called the estrogen-responsive element (ERE).
(11) The ovalbumin promoter half-palindromic ERE motif located close to the TATA box was required for the activity of the distal DH3 ERE, but could be replaced by the binding sites of other transactivators.
(12) The equilibrium constant for the redox equilibration of fatty acid synthase in a glutathione redox buffer is 15 mM (Ered + GSSG in equilibrium Eox + 2GSH).
(13) When sequenced, these elements showed remarkable diversity and were different from the consensus vitellogenin A2 ERE.
(14) However at 32 degrees C Ta, there was an increase in rectal temperature in response to haloperidol application; this hyperthermia was due to a decrease in both the ear blood flow and respiratory evaporative heat loss (Eres).
(15) The affinity of estradiol binding to receptors was reduced only 2- and 5-fold, respectively, in the double and quadruple Cys to Ala mutants, and estradiol was an effective stimulator of transcription from an estrogen-responsive reporter gene [(ERE)2-TATA-CAT].
(16) A stimulatory estrogen response element (ERE) was localized to a 32-bp region between -547 and -516 bp.
(17) In these genes, two ERE homologues, which have only low, if any, regulatory capacity on their own, act synergistically to achieve high estrogen inducibility.
(18) "Gnnmph, I can't 'ave it 'ere, I 'aven't 'ad my enema," wails a labouring housewife, straining fruitlessly on a communal tenement bog as horrified neighbours look on in their rollers.
(19) This ERE also mediated down-regulation by progestins in the presence of the progesterone receptor, even though it has no progesterone receptor binding ability.
(20) This 67 bp region contains a consensus for the core sequence of the glucocorticoid responsive element (GRE) and the estrogen responsive element (ERE).
Erg
Definition:
(n.) The unit of work or energy in the C. G. S. system, being the amount of work done by a dyne working through a distance of one centimeter; the amount of energy expended in moving a body one centimeter against a force of one dyne. One foot pound is equal to 13,560,000 ergs.
Example Sentences:
(1) Similar to intact crayfish, animals with an isolated protocerebrum-eyestalk complex, exhibit competent circadian rhythms in the electroretinogram (ERG).
(2) We have now started a prospective follow-up study in order to pursue the development of (a) p-ERG amplitudes and (b) funduscopic changes and visual acuity in these patients.
(3) Electroretinographic (ERG), morphometric and biochemical studies on retinas from monkeys or rats reveal that moderate level developmental lead (Pb) exposure produces long-term selective rod deficits and degeneration.
(4) The b-wave in the ERG was lacking and the EOG was flat.
(5) ERGs of high amplitude and of normal wave form were recordable with prominent oscillatory potentials.
(6) In chronical experiments the ERG of 5 rabbits were recorded before and after stimulation of the hippocampus.
(7) The wave forms of the equiluminance stimulus onset responses were similar to ERGs evoked with luminance decrease and the stimulus offset PERGs were like ERGs elicited by luminance increase.
(8) The ERG tested in a cell-free extract from one of these transformants proved to be resistant to the Al derivative, terbinafine.
(9) The highest yield of amino acids with the quench reaction was 9 x 10-7 molecules per erg of input energy.
(10) Normal retinal function can be maintained for several hours with the measurement of the gross electroretinogram (ERG) serving as a useful monitor of the electrophysiological condition of the preparation.
(11) We suggest that the initial supernormal ERG reflects an underlying biochemical change mediated by the action of anti retinal S-antigen antibodies.
(12) The postirradiation changes in the ERG wave amplitudes were most pronounced during the attenuating photokeratitis.
(13) The results strongly support the concept that the b-wave of the photopic ERG may actually represent a composite of potentials whose individual contributions are best visualized when the ERG is recorded with the 100- to 1000-Hz bandwidth.
(14) The ERG a-wave and b-amplitudes also decreased as a consequence of the taurine-free diet.
(15) The electroretinogram (ERG) was recorded in the dark from photo-entrained albino rabbits, using a constant-intensity, 500-nm, 50- or 100-msec stimulus at 1-min intervals.
(16) We hypothesize that the b-wave of the electroreginogram (ERG) can provide a precise, noninvasive measure of the morning rod disc shedding event.
(17) Pelmatohydra oligactis was amputated in the central part of the gastral region and exposed to radiation of ultraviolet rays (2535 angstroms, 12 erg mm(-2)s(-2) for 7, 15 and 20 minutes.
(18) ERG bp-waves were recorded in congenital color blindness by scanning monochromatic light stimuli, and spectral responses obtained could be evaluated as a spectral pattern.
(19) The data suggests that the b-wave of the ERG should be considered as a composite of potentials rather than as a single potential.
(20) The laser applications reduced considerably the amplitudes of the a and b waves of the ERG.