(1) At saturating concentrations of ER, plasmids bearing one, two, and four EREs in tandem bound approximately one, two, and four dimeric ER molecules, respectively.
(2) Interestingly, each of these fragments had a perfect palindromic estrogen responsive element (ERE) (GGT-CANNNTGACC).
(3) These data suggest that flanking DNA sequences may exert a significant effect on the activity of EREs as hormone-dependent transcription activators.
(4) In 11 spontaneously breathing patients with chronic obstructive pulmonary disease (COPD) in acute ventilatory failure, we measured the total inspiratory (WItot) and total resistive (WI + Eres) work rate of breathing, together with lung mechanics (dynamic pulmonary elastance and inspiratory and expiratory pulmonary flow resistance).
(5) This element binds to the estrogen receptor in vitro as assessed by gel retardation assay similar to the vitellogenin gene ERE.
(6) The two polypeptides are different as judged by peptide mapping, and only the 85-kDa polypeptide can be cross-linked to the bromodeoxyuridine-substituted synthetic ERE by UV irradiation.
(7) Two methods have been suggested for the calculation of pHapp and the loss of activity on particle preparation, these methods are based on the use of the ERE in conjunction with experimental data.
(8) These results suggest that the ability of ER and TR to functionally discriminate between an ERE and a TRE is a result of dimerization of their DBDs.
(9) The presence of the biologically active hER is confirmed in co-injection experiments, in which HEO is co-introduced with a CAT reporter gene under the control of a vitellogenin promoter containing or lacking the ERE.
(10) Gene transfer experiments using estrogen-responsive cells have shown that the 13 bp perfect palindromic element GGTCACTGTGACC found upstream of the Xenopus laevis vitellogenin gene A2 promoter mediates hormonal stimulation and thus, was called the estrogen-responsive element (ERE).
(11) The ovalbumin promoter half-palindromic ERE motif located close to the TATA box was required for the activity of the distal DH3 ERE, but could be replaced by the binding sites of other transactivators.
(12) The equilibrium constant for the redox equilibration of fatty acid synthase in a glutathione redox buffer is 15 mM (Ered + GSSG in equilibrium Eox + 2GSH).
(13) When sequenced, these elements showed remarkable diversity and were different from the consensus vitellogenin A2 ERE.
(14) However at 32 degrees C Ta, there was an increase in rectal temperature in response to haloperidol application; this hyperthermia was due to a decrease in both the ear blood flow and respiratory evaporative heat loss (Eres).
(15) The affinity of estradiol binding to receptors was reduced only 2- and 5-fold, respectively, in the double and quadruple Cys to Ala mutants, and estradiol was an effective stimulator of transcription from an estrogen-responsive reporter gene [(ERE)2-TATA-CAT].
(16) A stimulatory estrogen response element (ERE) was localized to a 32-bp region between -547 and -516 bp.
(17) In these genes, two ERE homologues, which have only low, if any, regulatory capacity on their own, act synergistically to achieve high estrogen inducibility.
(18) "Gnnmph, I can't 'ave it 'ere, I 'aven't 'ad my enema," wails a labouring housewife, straining fruitlessly on a communal tenement bog as horrified neighbours look on in their rollers.
(19) This ERE also mediated down-regulation by progestins in the presence of the progesterone receptor, even though it has no progesterone receptor binding ability.
(20) This 67 bp region contains a consensus for the core sequence of the glucocorticoid responsive element (GRE) and the estrogen responsive element (ERE).
Eve
Definition:
(n.) Evening.
(n.) The evening before a holiday, -- from the Jewish mode of reckoning the day as beginning at sunset. not at midnight; as, Christians eve is the evening before Christmas; also, the period immediately preceding some important event.
Example Sentences:
(1) Would people feel differently about it if, for instance, it happened on Boxing Day or Christmas Eve?
(2) When Vladimir Putin kicks back on New Year's Eve with a glass of Russian-made champagne, and reflects on the year behind him, he is likely to feel rather pleased with himself at the way his foreign policy initiatives have gone in 2013.
(3) Nadezhda Tolokonnikova and Maria Alyokhina were arrested on the eve of Russia's presidential vote last weekend, days after an impromptu performance of an anti-Putin song in Moscow's Cathedral of Christ the Saviour.
(4) Here, we show that Ultrabithorax and even-skipped homeo domain proteins (UBX and EVE) of Drosophila melanogaster exert active and opposite effects on in vitro transcription when bound to a common site upstream of a core promoter.
(5) The warning was issued as Miller held negotiations with the industry on the eve of an agreement by the three main parties over a royal charter, which was announced on Friday.
(6) These results provide evidence that the eve protein acts combinatorially with other transcription factors to enhance its own expression.
(7) The Guardian recently revealed that the Danish government had been forced, on the eve of the Copenhagen summit , to rush through an emergency law making it impossible for criminal gangs to reclaim huge amounts of VAT on fraudulent trades they were making on Europe's various carbon exchanges.
(8) "If nothing is done … the government will be demoralised on the eve of Rio+20."
(9) On the eve of the latest suicide data for the UK, Madeleine Moon, chair of the all-party parliamentary group for suicide and self-harm prevention (APPG), said a third of local authorities in England had no suicide action plan.
(10) 1.49pm GMT RobertNeville asks: RobertNeville 14 February 2014 10:11am This comment has been chosen by Guardian staff because it contributes to the debate Eve, I sometimes get the feeling that women's issues are cherry picked depending on where they live.
(11) Elsewhere, Lady Edith dares spend the night with her boyfriend, on the eve of his supposed departure to Germany, where he plans to become a citizen in order to divorce his wife on the grounds that she’s a lunatic, so that he may marry Edith.
(12) As candidates and supporters packed out cafes and community centres, desperate to shore up to support on caucus eve, life continued as normal for most Iowans on Monday – with many critical of how hopefuls for the Republican presidential nomination have conducted their campaigns.
(13) Later on Monday, Obama made a eve-of-convention visit to the flooded Louisiana coast to console victims of hurricane Isaac.
(14) The 69-kDa ttk protein has been shown to bind multiple sites within important regulatory elements of the pair-rule genes even-skipped (eve) and fushi tarazu (ftz), and it has been suggested that this protein may function as a repressor of ftz transcription.
(15) We suggest that the establishment of parasegment borders, a consequence of eve expression and witnessed by subsequent en expression, is a necessary precondition for homeotic gene expression in the visceral mesoderm.
(16) Adam and Eve sound like the original simple nuclear family, one plus one for life.
(17) Benefit claimants will face lie detector tests and will lose benefits for a month if found guilty of fiddling the system under proposals unveiled by Gordon Brown on the eve of today's Queen's speech .
(18) The eight people in the dock had been arrested following clashes between protesters and riot police at Bolotnaya Square in Moscow on 6 May 2012, the eve of Vladimir Putin's third inauguration as Russian president.
(19) The announcement comes on the eve of his departure from Downing Street tomorrow and is privately welcomed by Gordon Brown.
(20) The announcement came on the eve of the speech by the shadow chancellor, George Osborne , to the Conservative party conference in Manchester today.