(1) At saturating concentrations of ER, plasmids bearing one, two, and four EREs in tandem bound approximately one, two, and four dimeric ER molecules, respectively.
(2) Interestingly, each of these fragments had a perfect palindromic estrogen responsive element (ERE) (GGT-CANNNTGACC).
(3) These data suggest that flanking DNA sequences may exert a significant effect on the activity of EREs as hormone-dependent transcription activators.
(4) In 11 spontaneously breathing patients with chronic obstructive pulmonary disease (COPD) in acute ventilatory failure, we measured the total inspiratory (WItot) and total resistive (WI + Eres) work rate of breathing, together with lung mechanics (dynamic pulmonary elastance and inspiratory and expiratory pulmonary flow resistance).
(5) This element binds to the estrogen receptor in vitro as assessed by gel retardation assay similar to the vitellogenin gene ERE.
(6) The two polypeptides are different as judged by peptide mapping, and only the 85-kDa polypeptide can be cross-linked to the bromodeoxyuridine-substituted synthetic ERE by UV irradiation.
(7) Two methods have been suggested for the calculation of pHapp and the loss of activity on particle preparation, these methods are based on the use of the ERE in conjunction with experimental data.
(8) These results suggest that the ability of ER and TR to functionally discriminate between an ERE and a TRE is a result of dimerization of their DBDs.
(9) The presence of the biologically active hER is confirmed in co-injection experiments, in which HEO is co-introduced with a CAT reporter gene under the control of a vitellogenin promoter containing or lacking the ERE.
(10) Gene transfer experiments using estrogen-responsive cells have shown that the 13 bp perfect palindromic element GGTCACTGTGACC found upstream of the Xenopus laevis vitellogenin gene A2 promoter mediates hormonal stimulation and thus, was called the estrogen-responsive element (ERE).
(11) The ovalbumin promoter half-palindromic ERE motif located close to the TATA box was required for the activity of the distal DH3 ERE, but could be replaced by the binding sites of other transactivators.
(12) The equilibrium constant for the redox equilibration of fatty acid synthase in a glutathione redox buffer is 15 mM (Ered + GSSG in equilibrium Eox + 2GSH).
(13) When sequenced, these elements showed remarkable diversity and were different from the consensus vitellogenin A2 ERE.
(14) However at 32 degrees C Ta, there was an increase in rectal temperature in response to haloperidol application; this hyperthermia was due to a decrease in both the ear blood flow and respiratory evaporative heat loss (Eres).
(15) The affinity of estradiol binding to receptors was reduced only 2- and 5-fold, respectively, in the double and quadruple Cys to Ala mutants, and estradiol was an effective stimulator of transcription from an estrogen-responsive reporter gene [(ERE)2-TATA-CAT].
(16) A stimulatory estrogen response element (ERE) was localized to a 32-bp region between -547 and -516 bp.
(17) In these genes, two ERE homologues, which have only low, if any, regulatory capacity on their own, act synergistically to achieve high estrogen inducibility.
(18) "Gnnmph, I can't 'ave it 'ere, I 'aven't 'ad my enema," wails a labouring housewife, straining fruitlessly on a communal tenement bog as horrified neighbours look on in their rollers.
(19) This ERE also mediated down-regulation by progestins in the presence of the progesterone receptor, even though it has no progesterone receptor binding ability.
(20) This 67 bp region contains a consensus for the core sequence of the glucocorticoid responsive element (GRE) and the estrogen responsive element (ERE).
Eyre
Definition:
(n.) A journey in circuit of certain judges called justices in eyre (or in itinere).
Example Sentences:
(1) Jane Eyre has spawned a thousand luscious anti-heroes, and a million Pills & Swoon paperbacks.
(2) It is shown that the proposed model may be considered as being one particular case of that proposed by Lumry and Eyring [Lumry, R., & Eyring, H. (1954) J. Phys.
(3) The film, based on the bestselling novel by Uzodinma Iweala, stars Idris Elba and comes from Cary Fukunaga, acclaimed director of Jane Eyre and the HBO series True Detective , which won him an Emmy last year.
(4) Somewhere, glistening in the ashes, there might remain a copy of Jane Eyre.
(5) The corresponding values of enthalpy of activation (delta H*), entropy of activation (delta S*), and free energy of activation (delta G*) have been evaluated using Eyring's equation of absolute reaction rate.
(6) Both Dyke and Eyre have experience of running large broadcasting organisations.
(7) The heroine of Jane Eyre is hypnotised by this cold and saintly missionary, who proposes that they marry and go to India together to convert heathens (and perish doing God's holy work).
(8) The current-voltage curves were linear for membrane potentials up to 150 mV, which suggested that Nernst-Planck-type barriers rather than Eyring barriers were involved in the movement of anions through the protein P channel.
(9) A second inflection point in the Eyring plot could exist around 28 degrees C.
(10) A two-barrier Eyring model describes the slowed permeation and voltage dependence well for the three less permeant test cations.
(11) and Eyring, H. (1941) The theory of rate processes, McGraw-Hill, New York), the possible coupling between ion flux and the channel conformational transitions has been incorporated into the model by considering the dependence of the rate constants on the heights of the energy barriers.
(12) The experimental data are interpreted by two barrier membrane model bases of absolute reaction rate Eyring's theory.
(13) This observation is also consistent with our previously reported sigma data for human red cell membranes (Owen & Eyring, J. Gen. Physiol.
(14) Classic novels such as Great Expectations, Pride and Prejudice and Jane Eyre should be available in secondary schools for all pupils to read, according to schools minister Nick Gibb, who has challenged the UK’s publishers to make 100 classic titles available to schools at low prices.
(15) This paper examines the nature of the barrier to ion leaks, using the classical Eyring rate theory.
(16) Eyre left the Co-op in 2007 because he said he did not want to work with Peter Marks, who became chief executive that year.
(17) Rat growth response was greatest on the DWE diets, either with or without the supplements, was intermediate on the supplemented EYR diets, and was least on the unsupplemented EYR diets.
(18) Marks Barfield Architects, which has delivered a number of prestigious bridge projects, was asked, as was Wilkinson Eyre, a firm that has designed more than 25 bridges, including the Stirling prize-winning Gateshead Millennium Bridge .
(19) "It's utterly eclectic," says Sir Richard Eyre, who championed Lepage at the National Theatre.
(20) The I-V behavior for different K+-Na+ mixtures in the bath could be accurately described with a model based on Eyring theory, assuming two sites and one-ion occupancy.