(1) At saturating concentrations of ER, plasmids bearing one, two, and four EREs in tandem bound approximately one, two, and four dimeric ER molecules, respectively.
(2) Interestingly, each of these fragments had a perfect palindromic estrogen responsive element (ERE) (GGT-CANNNTGACC).
(3) These data suggest that flanking DNA sequences may exert a significant effect on the activity of EREs as hormone-dependent transcription activators.
(4) In 11 spontaneously breathing patients with chronic obstructive pulmonary disease (COPD) in acute ventilatory failure, we measured the total inspiratory (WItot) and total resistive (WI + Eres) work rate of breathing, together with lung mechanics (dynamic pulmonary elastance and inspiratory and expiratory pulmonary flow resistance).
(5) This element binds to the estrogen receptor in vitro as assessed by gel retardation assay similar to the vitellogenin gene ERE.
(6) The two polypeptides are different as judged by peptide mapping, and only the 85-kDa polypeptide can be cross-linked to the bromodeoxyuridine-substituted synthetic ERE by UV irradiation.
(7) Two methods have been suggested for the calculation of pHapp and the loss of activity on particle preparation, these methods are based on the use of the ERE in conjunction with experimental data.
(8) These results suggest that the ability of ER and TR to functionally discriminate between an ERE and a TRE is a result of dimerization of their DBDs.
(9) The presence of the biologically active hER is confirmed in co-injection experiments, in which HEO is co-introduced with a CAT reporter gene under the control of a vitellogenin promoter containing or lacking the ERE.
(10) Gene transfer experiments using estrogen-responsive cells have shown that the 13 bp perfect palindromic element GGTCACTGTGACC found upstream of the Xenopus laevis vitellogenin gene A2 promoter mediates hormonal stimulation and thus, was called the estrogen-responsive element (ERE).
(11) The ovalbumin promoter half-palindromic ERE motif located close to the TATA box was required for the activity of the distal DH3 ERE, but could be replaced by the binding sites of other transactivators.
(12) The equilibrium constant for the redox equilibration of fatty acid synthase in a glutathione redox buffer is 15 mM (Ered + GSSG in equilibrium Eox + 2GSH).
(13) When sequenced, these elements showed remarkable diversity and were different from the consensus vitellogenin A2 ERE.
(14) However at 32 degrees C Ta, there was an increase in rectal temperature in response to haloperidol application; this hyperthermia was due to a decrease in both the ear blood flow and respiratory evaporative heat loss (Eres).
(15) The affinity of estradiol binding to receptors was reduced only 2- and 5-fold, respectively, in the double and quadruple Cys to Ala mutants, and estradiol was an effective stimulator of transcription from an estrogen-responsive reporter gene [(ERE)2-TATA-CAT].
(16) A stimulatory estrogen response element (ERE) was localized to a 32-bp region between -547 and -516 bp.
(17) In these genes, two ERE homologues, which have only low, if any, regulatory capacity on their own, act synergistically to achieve high estrogen inducibility.
(18) "Gnnmph, I can't 'ave it 'ere, I 'aven't 'ad my enema," wails a labouring housewife, straining fruitlessly on a communal tenement bog as horrified neighbours look on in their rollers.
(19) This ERE also mediated down-regulation by progestins in the presence of the progesterone receptor, even though it has no progesterone receptor binding ability.
(20) This 67 bp region contains a consensus for the core sequence of the glucocorticoid responsive element (GRE) and the estrogen responsive element (ERE).
Fore
Definition:
(v. i.) Journey; way; method of proceeding.
(adv.) In the part that precedes or goes first; -- opposed to aft, after, back, behind, etc.
(adv.) Formerly; previously; afore.
(adv.) In or towards the bows of a ship.
(adv.) Advanced, as compared with something else; toward the front; being or coming first, in time, place, order, or importance; preceding; anterior; antecedent; earlier; forward; -- opposed to back or behind; as, the fore part of a garment; the fore part of the day; the fore and of a wagon.
(n.) The front; hence, that which is in front; the future.
(prep.) Before; -- sometimes written 'fore as if a contraction of afore or before.
Example Sentences:
(1) There fore, the adverse effects may be induced by such quartz or silicon compounds.
(2) White House plan to hire more border agents raises vetting fear, ex-senior official says Read more “But the fact is when the world changed, you have to change too, and so I do think there are amazing new opportunities now because he’s bringing nationalism to the fore, he’s bringing it into the mainstream, he’s asking these existential questions like: are we a nation?
(3) While executing the latter movements no forward locomotion occurred at all; the cats solely executed lateral fore- and hindlimb movements opposite to the direction in which the cylinder rotated.
(4) This caused variations in fore-and-aft motion with position along the vertical axis of the head and variations in vertical motion with position along the fore-and-aft axis of the head.
(5) Moreover in the symmetrical gaits spatial phase shifts between unilateral limbs were equal to zero, which means that hind and fore limbs were placed in the same point during successive steps.
(6) No evidence for a differential decussation of fore-limb and hind-limb fibers was found.
(7) Standard 5-member series of weak electro-cutaneous stimulations of the fore-paw were applied in chronic experiments to two dogs with implanted cortical electrodes.
(8) Electromyographic studies revealed some abnormal insertional activity but no abnormal potentials when the fore- and hindlimb muscles were at total rest.
(9) Taking a break from rehearsal, police baton in hand, the 34-year-old said: "It doesn't point to anybody, but it brings to the fore the pain the tragic event cost.
(10) These fibers accumulated dorsomedially to the rostral pole of the substantia nigra where they formed a massive bundle that coursed through the prerubral field and ascended along the laterodorsal aspect of the medial fore-brain bundle in the lateral hypothalamus.
(11) The receptive fields of 48 specific cold units, located in the hairy and glaborous skin of fore- and hindlimbs of rhesus monkeys, were mapped and scale drawings made.
(12) The rat somatosensory (SI) cortex contains a precise map of the cutaneous periphery, yet its rostromedial edge, which includes part of the fore- and hind paw representation, has been reported to functionally overlap with the electrically excitable primary motor (MI) cortex.
(13) While gender violence occurs worldwide, the problem has come to the fore in several countries in Latin America through the work of prominent feminist groups, many of which argue their region is particularly plagued by social insecurity and male-dominated traditions.
(14) Exposure to phosphoramide mustard produced limb reduction malformations in both the fore- and hindlimbs; total limb bone area was greatly reduced, while the relative contribution of the paw to this area in forelimbs was increased.
(15) Periodontal disease is therefore considered a fore-runner to the clinically more important spinal osteoporosis.
(16) For this enzyme beside the nuclei, the commissures and fore-brain bundles are seen equipped with very intense activity.
(17) ACR-CH or aclarubicin aqueous solution (ACR-sol) was injected subcutaneously into the fore foot-pads of rats.
(18) We have examined early neuronal differentiation and axonogenesis in the fore- and midbrain of zebrafish embryos to address general issues of early vertebrate brain development.
(19) The impulses of fore-aft force were closely correlated with step length.
(20) Excessive weight-bearing on the complete fore-foot as a consequence of missing support by contracted metatarsophalangeal joints.