(1) At saturating concentrations of ER, plasmids bearing one, two, and four EREs in tandem bound approximately one, two, and four dimeric ER molecules, respectively.
(2) Interestingly, each of these fragments had a perfect palindromic estrogen responsive element (ERE) (GGT-CANNNTGACC).
(3) These data suggest that flanking DNA sequences may exert a significant effect on the activity of EREs as hormone-dependent transcription activators.
(4) In 11 spontaneously breathing patients with chronic obstructive pulmonary disease (COPD) in acute ventilatory failure, we measured the total inspiratory (WItot) and total resistive (WI + Eres) work rate of breathing, together with lung mechanics (dynamic pulmonary elastance and inspiratory and expiratory pulmonary flow resistance).
(5) This element binds to the estrogen receptor in vitro as assessed by gel retardation assay similar to the vitellogenin gene ERE.
(6) The two polypeptides are different as judged by peptide mapping, and only the 85-kDa polypeptide can be cross-linked to the bromodeoxyuridine-substituted synthetic ERE by UV irradiation.
(7) Two methods have been suggested for the calculation of pHapp and the loss of activity on particle preparation, these methods are based on the use of the ERE in conjunction with experimental data.
(8) These results suggest that the ability of ER and TR to functionally discriminate between an ERE and a TRE is a result of dimerization of their DBDs.
(9) The presence of the biologically active hER is confirmed in co-injection experiments, in which HEO is co-introduced with a CAT reporter gene under the control of a vitellogenin promoter containing or lacking the ERE.
(10) Gene transfer experiments using estrogen-responsive cells have shown that the 13 bp perfect palindromic element GGTCACTGTGACC found upstream of the Xenopus laevis vitellogenin gene A2 promoter mediates hormonal stimulation and thus, was called the estrogen-responsive element (ERE).
(11) The ovalbumin promoter half-palindromic ERE motif located close to the TATA box was required for the activity of the distal DH3 ERE, but could be replaced by the binding sites of other transactivators.
(12) The equilibrium constant for the redox equilibration of fatty acid synthase in a glutathione redox buffer is 15 mM (Ered + GSSG in equilibrium Eox + 2GSH).
(13) When sequenced, these elements showed remarkable diversity and were different from the consensus vitellogenin A2 ERE.
(14) However at 32 degrees C Ta, there was an increase in rectal temperature in response to haloperidol application; this hyperthermia was due to a decrease in both the ear blood flow and respiratory evaporative heat loss (Eres).
(15) The affinity of estradiol binding to receptors was reduced only 2- and 5-fold, respectively, in the double and quadruple Cys to Ala mutants, and estradiol was an effective stimulator of transcription from an estrogen-responsive reporter gene [(ERE)2-TATA-CAT].
(16) A stimulatory estrogen response element (ERE) was localized to a 32-bp region between -547 and -516 bp.
(17) In these genes, two ERE homologues, which have only low, if any, regulatory capacity on their own, act synergistically to achieve high estrogen inducibility.
(18) "Gnnmph, I can't 'ave it 'ere, I 'aven't 'ad my enema," wails a labouring housewife, straining fruitlessly on a communal tenement bog as horrified neighbours look on in their rollers.
(19) This ERE also mediated down-regulation by progestins in the presence of the progesterone receptor, even though it has no progesterone receptor binding ability.
(20) This 67 bp region contains a consensus for the core sequence of the glucocorticoid responsive element (GRE) and the estrogen responsive element (ERE).
(Superl.) Only this, and nothing else; such, and no more; simple; bare; as, a mere boy; a mere form.
Example Sentences:
(1) Interphase death thus involves a discrete, abrupt transition from the normal state and is not merely the consequence of progressive and degenerative changes.
(2) By way of major complications, merely one perforation occurred.
(3) Indeed, the nationalist and religious right bloc merely held steady , gaining just one seat.
(4) A brief review of the last decade or so of developments in health politics, policy and law suggests that health is no longer a field of mere "dynamics without change."
(5) The view that testes found lateral to the external ring and which could be pushed some way into the scrotum were merely retractile was questioned.
(6) In these three patients, laxity of the knee in flexion was so severe that posterior instability could not be corrected merely by patellar relocation.
(7) It has so far returned a mere $6m (£3.6m) of its relatively meagre $28m (£17.1m) budget, according to Forbes, a percentage of just 21%.
(8) In the literature this disease is presented merely as a metastasis.
(9) The plasmid-encoded activity does not merely replace the RecBCD enzyme failure but differs in several significant ways.
(10) Furthermore, changes between merely perceived identical parts can result in apparent depth.
(11) Thus, the long stalks of Sk1 or phosphate-starved caulobacters are not merely a function of their longer doubling times.
(12) Exogenous macromolecular DNA was able to repair, to an important degree the radiotoxic effect of 3H-thymidine on V79 cells by a mechanism other than the mere reduction of specific activity of 3H-thymidine.
(13) Multiple contacts between the gamma-subunit and calmodulin (delta-subunit), as indicated by our data, may help to explain why strongly denaturing conditions are required to dissociate these two subunits, whereas complexes of calmodulin with most other target enzymes can be readily dissociated by merely lowering Ca2+ to submicromolar concentrations.
(14) Scott insisted he was an abstract painter in the way he felt Chardin was too: the pans and fruit were uninteresting in themselves; they were merely "the means of making a picture", which was a study in space, form and colour.
(15) The charity Bite the Ballot , which persuaded hundreds of thousands to register before the last general election, is to set up “democracy cafes” in Starbucks branches, laying on experts to explain how to register and vote, and what the referendum is all about (Bite the Ballot does not take sides but merely encourages participation).
(16) These outcomes further supported the conclusion that the contextual stimuli exerted true conditional control over conditional relations in the equivalence classes and were not merely elements of compound stimuli.
(17) A mere glance at the time courses shows what reaction schemes are inapplicable.
(18) Since the discovery of the antidepressant effects of interventions in the sleep-wake cycle, a number of hypotheses have emerged according to which disturbances in sleep physiology are not merely expressions but essential components of the pathophysiology of depression.
(19) In a Facebook post , the songwriter and activist claims that Swift has merely chosen sides in the battle between Google and Spotify, saying that the singer was trying to “sell this corporate power play to us as some sort of altruistic gesture in solidarity with struggling music makers”.
(20) It is assumed that one function of grooming behaviour may be a merely cleansing one.