(1) At saturating concentrations of ER, plasmids bearing one, two, and four EREs in tandem bound approximately one, two, and four dimeric ER molecules, respectively.
(2) Interestingly, each of these fragments had a perfect palindromic estrogen responsive element (ERE) (GGT-CANNNTGACC).
(3) These data suggest that flanking DNA sequences may exert a significant effect on the activity of EREs as hormone-dependent transcription activators.
(4) In 11 spontaneously breathing patients with chronic obstructive pulmonary disease (COPD) in acute ventilatory failure, we measured the total inspiratory (WItot) and total resistive (WI + Eres) work rate of breathing, together with lung mechanics (dynamic pulmonary elastance and inspiratory and expiratory pulmonary flow resistance).
(5) This element binds to the estrogen receptor in vitro as assessed by gel retardation assay similar to the vitellogenin gene ERE.
(6) The two polypeptides are different as judged by peptide mapping, and only the 85-kDa polypeptide can be cross-linked to the bromodeoxyuridine-substituted synthetic ERE by UV irradiation.
(7) Two methods have been suggested for the calculation of pHapp and the loss of activity on particle preparation, these methods are based on the use of the ERE in conjunction with experimental data.
(8) These results suggest that the ability of ER and TR to functionally discriminate between an ERE and a TRE is a result of dimerization of their DBDs.
(9) The presence of the biologically active hER is confirmed in co-injection experiments, in which HEO is co-introduced with a CAT reporter gene under the control of a vitellogenin promoter containing or lacking the ERE.
(10) Gene transfer experiments using estrogen-responsive cells have shown that the 13 bp perfect palindromic element GGTCACTGTGACC found upstream of the Xenopus laevis vitellogenin gene A2 promoter mediates hormonal stimulation and thus, was called the estrogen-responsive element (ERE).
(11) The ovalbumin promoter half-palindromic ERE motif located close to the TATA box was required for the activity of the distal DH3 ERE, but could be replaced by the binding sites of other transactivators.
(12) The equilibrium constant for the redox equilibration of fatty acid synthase in a glutathione redox buffer is 15 mM (Ered + GSSG in equilibrium Eox + 2GSH).
(13) When sequenced, these elements showed remarkable diversity and were different from the consensus vitellogenin A2 ERE.
(14) However at 32 degrees C Ta, there was an increase in rectal temperature in response to haloperidol application; this hyperthermia was due to a decrease in both the ear blood flow and respiratory evaporative heat loss (Eres).
(15) The affinity of estradiol binding to receptors was reduced only 2- and 5-fold, respectively, in the double and quadruple Cys to Ala mutants, and estradiol was an effective stimulator of transcription from an estrogen-responsive reporter gene [(ERE)2-TATA-CAT].
(16) A stimulatory estrogen response element (ERE) was localized to a 32-bp region between -547 and -516 bp.
(17) In these genes, two ERE homologues, which have only low, if any, regulatory capacity on their own, act synergistically to achieve high estrogen inducibility.
(18) "Gnnmph, I can't 'ave it 'ere, I 'aven't 'ad my enema," wails a labouring housewife, straining fruitlessly on a communal tenement bog as horrified neighbours look on in their rollers.
(19) This ERE also mediated down-regulation by progestins in the presence of the progesterone receptor, even though it has no progesterone receptor binding ability.
(20) This 67 bp region contains a consensus for the core sequence of the glucocorticoid responsive element (GRE) and the estrogen responsive element (ERE).
Pere
Definition:
(n.) A peer.
Example Sentences:
(1) Likud warned: “Peres will divide Jerusalem.” Arab states feared that his dream of a borderless Middle East spelled Israeli economic colonialism by stealth.
(2) A state memorial event will be held at the Knesset on Monday morning , addressed by the prime minister, Binyamin Netanyahu, Peres and Sharon's sons Gilad and Omri.
(3) Statements by Kerry, Israeli president Shimon Peres and Arab League representatives on Wednesday and Thursday indicated that significant progress had been made.
(4) But the heart of the visit will be an address to the Knesset, the Israeli parliament, and meetings with the Israeli prime minister, Binyamin Netanyahu, and President Shimon Peres.
(5) Israel's outgoing president, Shimon Peres, and his successor, Reuven Rivlin, promised in a joint editorial published in Yedioth Ahronoth, the country's best-selling newspaper, on Monday that there would be no cover-up in the investigation of Abu Khdeir's death.
(6) His office said Peres received a pacemaker last week.
(7) In 1986, while serving as prime minister and foreign minister, Peres held negotiations that led to the London agreement, the ultimately futile peace accord that included Israeli-Jordanian cooperation in administrating the West Bank.
(8) He especially welcomed Peres, reappointed Labour leader after Barak's resignation.
(9) Peres was discharged from hospital last week after suffering a heart attack.
(10) Shimon Peres, president of Israel, praised Mandela as "a builder of bridges of peace and dialogue who paid a heavy personal price for his struggle in the years he spent in prison and fighting for his people".
(11) His many detractors said that Peres simply had no choice.
(12) A spokesman said: “The president will participate in the funeral of former Israeli president Shimon Peres.
(13) Yet many Palestinians blamed Peres for saddling them with inferior terms in the Paris economic deal of 1994.
(14) The outpouring of support displayed the domestic political capital Erdogan gained from his performance at the Swiss resort, where he told Peres: "When it comes to killing, you know very well how to kill."
(15) Though he conceded that Arab leaders saw his creation, Israel’s secret Dimona plant in the Negev Desert, as “a worrisome fuzzy deterrent”, Peres the politician enjoyed creating such deliberate ambiguities.
(16) Support for Peres evaporated when successive bomb attacks killed dozens in Tel Aviv and Jerusalem, and talks with Syria came to naught.
(17) But by feting two cynical politicians who have sought to harness religious feelings for their own agendas, as Abbas is doing now with the furore over the Jerusalem mosques and Peres did nearly 40 years ago – when, as defence minister, he authorised the first settlements in the West Bank, in the hope the settlers would support him against his rival Yitzhak Rabin – the pope helped perpetuate the myth.
(18) Releasing the new images of the potential witness, DCI Chris Le Pere, who is in charge of the investigation, said: “We are appealing for this man to come forward so we can speak to him to establish if he can assist with our inquiries, or if we can eliminate this strand of the investigation.
(19) A 1-0 Costa Rica success resonates as much to this day with Scotland’s followers as Archie Gemmill’s 1978 wonder-goal against Holland or David Narey’s spectacular toe-poke past Brazil’s Waldir Peres four years later in Spain.
(20) By standing down, he avoided splitting the rightist vote and thus allowed Netanyahu to narrowly beat the prime minister Peres.