(1) At saturating concentrations of ER, plasmids bearing one, two, and four EREs in tandem bound approximately one, two, and four dimeric ER molecules, respectively.
(2) Interestingly, each of these fragments had a perfect palindromic estrogen responsive element (ERE) (GGT-CANNNTGACC).
(3) These data suggest that flanking DNA sequences may exert a significant effect on the activity of EREs as hormone-dependent transcription activators.
(4) In 11 spontaneously breathing patients with chronic obstructive pulmonary disease (COPD) in acute ventilatory failure, we measured the total inspiratory (WItot) and total resistive (WI + Eres) work rate of breathing, together with lung mechanics (dynamic pulmonary elastance and inspiratory and expiratory pulmonary flow resistance).
(5) This element binds to the estrogen receptor in vitro as assessed by gel retardation assay similar to the vitellogenin gene ERE.
(6) The two polypeptides are different as judged by peptide mapping, and only the 85-kDa polypeptide can be cross-linked to the bromodeoxyuridine-substituted synthetic ERE by UV irradiation.
(7) Two methods have been suggested for the calculation of pHapp and the loss of activity on particle preparation, these methods are based on the use of the ERE in conjunction with experimental data.
(8) These results suggest that the ability of ER and TR to functionally discriminate between an ERE and a TRE is a result of dimerization of their DBDs.
(9) The presence of the biologically active hER is confirmed in co-injection experiments, in which HEO is co-introduced with a CAT reporter gene under the control of a vitellogenin promoter containing or lacking the ERE.
(10) Gene transfer experiments using estrogen-responsive cells have shown that the 13 bp perfect palindromic element GGTCACTGTGACC found upstream of the Xenopus laevis vitellogenin gene A2 promoter mediates hormonal stimulation and thus, was called the estrogen-responsive element (ERE).
(11) The ovalbumin promoter half-palindromic ERE motif located close to the TATA box was required for the activity of the distal DH3 ERE, but could be replaced by the binding sites of other transactivators.
(12) The equilibrium constant for the redox equilibration of fatty acid synthase in a glutathione redox buffer is 15 mM (Ered + GSSG in equilibrium Eox + 2GSH).
(13) When sequenced, these elements showed remarkable diversity and were different from the consensus vitellogenin A2 ERE.
(14) However at 32 degrees C Ta, there was an increase in rectal temperature in response to haloperidol application; this hyperthermia was due to a decrease in both the ear blood flow and respiratory evaporative heat loss (Eres).
(15) The affinity of estradiol binding to receptors was reduced only 2- and 5-fold, respectively, in the double and quadruple Cys to Ala mutants, and estradiol was an effective stimulator of transcription from an estrogen-responsive reporter gene [(ERE)2-TATA-CAT].
(16) A stimulatory estrogen response element (ERE) was localized to a 32-bp region between -547 and -516 bp.
(17) In these genes, two ERE homologues, which have only low, if any, regulatory capacity on their own, act synergistically to achieve high estrogen inducibility.
(18) "Gnnmph, I can't 'ave it 'ere, I 'aven't 'ad my enema," wails a labouring housewife, straining fruitlessly on a communal tenement bog as horrified neighbours look on in their rollers.
(19) This ERE also mediated down-regulation by progestins in the presence of the progesterone receptor, even though it has no progesterone receptor binding ability.
(20) This 67 bp region contains a consensus for the core sequence of the glucocorticoid responsive element (GRE) and the estrogen responsive element (ERE).
Yer
Definition:
(prep.) Ere; before.
Example Sentences:
(1) Kömür santrallerinin yarattığı tehdit yerli yerinde duruyor ve çevre köylerden biri olan Tarlaağzı sakinleri derin kül çukurları kazılmasından ve hava kirliliğinden endişe ediyorlar.
(2) Along with Mark Ravenhill ’s Shopping and Fucking , Sarah Kane ’s Blasted , Jez Butterworth ’s Mojo and Jonathan Harvey ’s Beautiful Thing , Dealer’s Choice heralded the dawn of a loose dramatic movement which earned the title “in-yer-face” drama.
(3) During the day, I knew, Adam was Adam Shefki, a la w yer.
(4) "Make as much noise as yer like," he continues, leeringly, over the incessant crraaang of the mechanised looms.
(5) I am very emotionally moved Yer've come 'ere with a lorra heart and that From the start of this competition you have acquitted yourself very ably Hawaaaaayyyyy the girls!
(6) Yer man Ian McCourt wrote the rest, and here's one of his bits: Some people knock on wood.
(7) I think I heard Dennis Skinner growl: "On yer exercise bike!"
(8) "Yer all orphans and bastards," snarls dastardly foreman Charlie Crout (Craig Parkinson) as oppressed urchins gulp and clench their bumcheeks.
(9) Hilary is less than enthusiastic: "Yer know, I don't think I could live with me'self if something happened to you," she says, rather reasonably.
(10) hueandcry.co.uk On first listening, the Iran team’s national anthem “Soroud-e Melli-e Jomhouri-e Eslami-e Iran” sounds like yer standard pomptastic European 19th-century neo-classicism.
(11) Last month he told Newsnight that unemployed people in Merthyr Tydfil would be well advised to take the bus to Cardiff to look for work, an echo of Norman Tebbit's "On yer bike" remark from 1981.
(12) In others he introduces us to Joe Craddock, his school German teacher, lamenting that Craddock's insistence on excellence ("Yer utterly useless!"
(13) These are some of the clever adaptations Generation Yers have developed to cope with distance.
(14) MORON July 6, 2014 Here's the article that has vexed him so , and I'm not entirely convinced that yer man has read it properly.
(15) "Yer goin' ter be a gennelmun in Lunnun,' cried Joe.
(16) Yer's alreet on the sleur ones, but whatzza racket am I hearing noo, man?
(17) klebs, yers) can use several mechanisms to overcome tolerance in their host.
(18) While in office, Hawke signed off a testimonial video for his mate with the words "Good on yer, Kerry, you've been true blue [loyal]."
(19) Earlier this month, he made fun of the Sinn Féin culture minister in the Stormont parliament with the words: “curry my yoghurt can coca coal yer” – a send-up of the Irish for “thank you, speaker.” Despite complaints from Sinn Féin as well as the SDLP and Irish-language organisations, Campbell continued to mock Gaelic.
(20) That's yer lot from me, thanks for your time and your emails.