(1) With NaCl as the major constituent of the bathing solution (potassium-free pipette and external solutions) the reversal potential (Er) of the noradrenaline-evoked current was about 0 mV.
(2) The overall recoveries of activated ER following chromatography on DEAE-cellulose were significantly lower than the recoveries of the nonactivated ER, 71 and 85%, respectively.
(3) Expression of AR was compared with that of ER and PR as well as with tumour grade and age.
(4) Furthermore, we did not observe correlation between the concentrations of ER and of antiestrogen binding sites (AEBS) in the tumors.
(5) In Stage II patients, chemotherapy has an impact on disease mortality for ER-positive and ER-negative premenopausal women and possibly ER-negative postmenopausal patients.
(6) Plasmids containing the inverted repeat alone bound ER, though less efficiently than did plasmids containing the entire sequence.
(7) It was found that the number of ER in the patients was significantly decreased.
(8) In human breast cancer the proliferating cells appear to differ from those containing estrogen receptors (ER) as shown by studies on isolated cellular subpopulations.
(9) Evidence for Golgi apparatus-associated processing of oligosaccharides in the ER was obtained by lectin-gold cytochemistry revealing the presence of the galactose (beta 1----4)N-acetylglucosamine sequence and sialic acid residues.
(10) Tissues were processed for indirect immunocytochemical localization with specific monoclonal antibodies against estrogen receptor (ER; H222) and progestin receptor (PR; JZB39).
(11) AR and ER mRNA-containing neurons were widely distributed in the rat brain, with the greatest densities of cells in the hypothalamus, and in regions of the telencephalon that provide strong inputs in the medial preoptic and ventromedial nuclei, each of which is thought to play a key role in mediating the hormonal control of copulatory behavior, as well as in the lateral septal nucleus, the medial and cortical nuclei of the amygdala, the amygdalohippocampal area, and the bed nucleus of the stria terminalis.
(12) At saturating concentrations of ER, plasmids bearing one, two, and four EREs in tandem bound approximately one, two, and four dimeric ER molecules, respectively.
(13) Such data provide strong evidence that in this concentration range the growth inhibitory effects of nonsteroidal antioestrogens are mediated by the intracellular ER.
(14) The expression of the ER cDNA in HeLa cells produces a protein that has the same relative molecular mass and binds oestradiol with the same affinity as the MCF-7 ER.
(15) Both methods, which are applicable to paraffin sections, were developed and validated in breast carcinomas with known ER content.
(16) Our results suggest that the synthesis of ER in cervical epithelium can be influenced by underlying stroma.
(17) Despite fulfilling a boyhood wish to play for Milan when he returned to Italy, the striker admitted he erred in taking his career back to Serie A, having had a controversial spell at Internazionale before City recruited him for £17.5m in August 2010.
(18) We have performed a quantitative analysis of steady-state levels of ER-mRNA for 88 untreated, primary breast carcinomas.
(19) Under these conditions, it was shown that resident enzymes of the cis-, medial, and trans-Golgi return to the ER.
(20) In freeze-fracture replicas the ER was seen to consist of both short and long tubules, some of the latter forming anastomoses with each other.
Sin
Definition:
(adv., prep., & conj.) Old form of Since.
(n.) Transgression of the law of God; disobedience of the divine command; any violation of God's will, either in purpose or conduct; moral deficiency in the character; iniquity; as, sins of omission and sins of commission.
(n.) An offense, in general; a violation of propriety; a misdemeanor; as, a sin against good manners.
(n.) A sin offering; a sacrifice for sin.
(n.) An embodiment of sin; a very wicked person.
(n.) To depart voluntarily from the path of duty prescribed by God to man; to violate the divine law in any particular, by actual transgression or by the neglect or nonobservance of its injunctions; to violate any known rule of duty; -- often followed by against.
(n.) To violate human rights, law, or propriety; to commit an offense; to trespass; to transgress.
Example Sentences:
(1) Molsidomine and SIN-1 were tested in a thrombosis model in which thrombi are produced in small mesenteric vessels.
(2) These results support a hypothesis which proposes that ancestral SIN virus diverged into two distinct groups.
(3) Our studies show that SIN-1 and C87-3754 exert beneficial effects in a 6-h model of myocardial ischemia-reperfusion.
(4) Antibodies to all viruses were detected, and namely in these frequencies: SIN 0.9%, WN 16.9%, TAH 41.5%, CVO 23.1% and TBE 8.5%.
(5) As the later Spark might have said, a mortal sin against the commandment to love beauty wherever one may find it.
(6) The direct acting stimulants of soluble guanylate cyclase, sodium nitroprusside and SIN-1 (3-morpholino-sydnonimine), also increased the cGMP content of endothelial cells by 9.4 and 7.2 times, respectively.
(7) In superfused precontracted strips of rabbit aorta, methylene blue (MeB) or pyocyanin (Pyo, 1-hydroxy-5-methyl phenazinum betaine) at concentrations of 1-10 microM inhibited relaxations induced by endothelium-derived relaxing factor (EDRF), glyceryl trinitrate (GTN), S-nitroso-N-acetyl-penicillamine (SNAP) or 3-morpholino-sydnonimine (SIN-1).
(8) The likes of almond, blackberry and crocus first made way for analogue, block graph and celebrity in the Oxford Junior Dictionary in 2007, with protests at the time around the loss of a host of religious words such as bishop, saint and sin.
(9) These prostanoids were measured in platelets and endothelial cells alone or during their interaction, in the absence or presence of SIN-1.
(10) The haemodynamic effects of N-carboxy-3-morpholino-sydronimine-ethylester (molsidomine, SIN 10, Corvaton) were studied in anaesthetized mongrel dogs.
(11) The results indicated that both Sin B and Sal have inductive actions on drug metabolizing-phase I and phase II enzymes in mice and rats.
(12) Ten women with SIN were bilaterally salpingectomized.
(13) Analysis of the relationship between the pharmacodynamics and pharmacokinetics of SIN-1 suggests that an active metabolites is involved.
(14) The guanidine 3', 5'-cyclic monophosphate (cGMP) content (an index of EDRF production) was determined by radioimmunoassay under basal conditions and after acetylcholine (10(-5) M), bradykinin (10(-5) M) and SIN-1 (10(-4) M) stimulation.
(15) sin- mutants (defining six genes) were identified because they express HO in the absence of particular SWI products.
(16) We studied the effects of intracoronary injections of SIN-1 (0.8 mg), the active metabolite of molsidomine, on coronary artery diameters and coronary stenoses.
(17) Sessions included "naming the sin, lifting the shame" and "normal sinfulness or a sickness".
(18) The nitric oxide donor compound, 3-morpholinosydnonimine (SIN-1), was equipotent at relaxing the central and peripheral airways.
(19) Oxyhaemoglobin used for the assay of NO, inhibited the relaxation by SIN-1, but did not reduce vessel relaxations induced by GTN or iloprost, a stable prostacyclin analogue.
(20) A degraded SIN-1 solution that did not release NO was unable to block NMDA receptors.