(1) In contrast, TTR(Met30) was relatively enriched in cerebrospinal fluid samples from two FAP patients.
(2) Haplotype analysis revealed that the Val----Met mutation has recurred frequently in the population to generate the FAP families of independent origins.
(3) An informative Dutch pedigree showed that two other linked polymorphic DNA markers, Pi227 and YN5.48, closely flank the FAP locus, one on either side.
(4) Studies of the molecular genetics of colon cancer have identified acquired alterations in oncogenes such as the K-ras gene and in putative tumor suppressor genes such as the FAP gene on chromosome 5, the p53 gene on chromosome 17, and the DCC gene on chromosome 18, which appear to mediate important steps in the adenoma-dysplasia-carcinoma sequence.
(5) The tumors themselves were FAP protein negative, as were the nonpancreatic tumors and normal organs.
(6) These clinical features closely resembled familial amyloid polyneuropathy (FAP), but abnormal serum prealbumin levels, specific to FAP (Japanese type), were not detected by radioimmunoassay; DNA sequence for prealbumin was normal.
(7) In FAP group (7 males and 5 females) the average age was 55 (range 30 to 74).
(8) Other probes, however, should be useful for assessing FAP inheritance by restriction fragment length polymorphism analysis, for presymptomatic diagnosis of the disease.
(9) Proteins with lower molecular weight than the PA monomer were major proteins in both SSA and FAP fibrils.
(10) Colchicine or Dimethyl-Sulphoxide (DMSO) treatment may prevent the development of FAP.
(11) Genomic DNA was isolated from peripheral blood lymphocytes of a patient with familial amyloidotic polyneuropathy (FAP) and the transthyretin (TTR) gene examined for sequence mutations.
(12) Patients with FAP develop multiple benign colorectal tumors.
(13) A recent study of FAP (5-FU, doxorubicin, cisplatin) has reported a 50% response rate with a significant number of CRs.
(14) Other dominantly-inherited colorectal cancer syndromes produce less striking phenotypes, but affect far more individuals than FAP.
(15) Sialic acid heterogeneity probably has a genetic basis, but this is not associated with the genetic defect underlying FAP.
(16) MF was found most often in FAP patients with associated extra-colonic "Gardner" signs (19 patients) and those who had had previous abdominal surgery (20 patients).
(17) This is the first report of chromosome 18 allele loss in colorectal carcinomas from FAP patients and concurrent allele losses on chromosomes 5 and 18 in sporadic colorectal cancer.
(18) Subsequent linkage analysis in six pedigrees, three having the FPC phenotype and three segregating GS, placed the FAP locus very close to a new marker, YN5.48 (D5S81), that is approximately 17 centimorgans distal to C11p11 on the genetic map.
(19) In a prospective study, 34 patients at 50% risk of inheriting FAP were examined.
(20) The coexistence of populations with severe duodenal and rectal polyposis suggests that environmental factors are important in phenotypic expression in FAP.
Far
Definition:
(n.) A young pig, or a litter of pigs.
(a.) Distant in any direction; not near; remote; mutually separated by a wide space or extent.
(a.) Remote from purpose; contrary to design or wishes; as, far be it from me to justify cruelty.
(a.) Remote in affection or obedience; at a distance, morally or spiritually; t enmity with; alienated.
(a.) Widely different in nature or quality; opposite in character.
(a.) The more distant of two; as, the far side (called also off side) of a horse, that is, the right side, or the one opposite to the rider when he mounts.
(adv.) To a great extent or distance of space; widely; as, we are separated far from each other.
(adv.) To a great distance in time from any point; remotely; as, he pushed his researches far into antiquity.
(adv.) In great part; as, the day is far spent.
(adv.) In a great proportion; by many degrees; very much; deeply; greatly.
Example Sentences:
(1) These results indicated that the PG determination was the most accurate predictor of fetal lung well-being prior to birth among the clinical tests so far reported.
(2) As far as acrophase table is concerned for all enzymes and fractions the acrophase occurred during the night.
(3) A commensurate rise in both smoking and adenocarcinoma has occurred in the Far East where the incidence rate (40%) is twice that of North America or Europe.
(4) Brown's model, which goes far further than those from any other senior Labour figure, and the modest new income tax powers for Holyrood devised when he was prime minister, edge the party much closer to the quasi-federal plans championed by the Liberal Democrats.
(5) It contains 10,000 apartments so far, in blocks that might appear Soviet but for shades of blue, green and yellow.
(6) But not only did it post a larger loss than expected, Amazon also projected 7% to 18% revenue growth over the busiest shopping period of the year, a far cry from the 20%-plus pace that had convinced investors to overlook its persistent lack of profit in the past.
(7) Mary's grief, which lasts for about the first half of the two-hour premiere special, is the finest work of the series so far by Michelle Dockery.
(8) I hope I can play a major part in really highlighting the need for far more extensive family violence training within all organisations that deal with women and children, including the police and the department of human services,” Batty said.
(9) Reasons for non-acceptance do not indicate any major difficulties in the employment of such staff in general practice, at least as far as the patients are concerned.
(10) Little is so far known of the origin of this syndrome.
(11) Although there was already satisfaction in the development of dementia-friendly pharmacies and Pride in Practice, a new standard of excellence in healthcare for gay, lesbian and bisexual patients, the biggest achievement so far was the bringing together of a strategic partnership of 37 NHS, local government and social organisations.
(12) Unlikely, he laughs: "We were founded on the idea of distributing information as far as possible."
(13) US presidential election 2016: the state of the Republican race as the year begins Read more So far, the former secretary of state seems to be recovering well from self-inflicted wounds that dogged the start of her second, and most concerted, attempt for the White House.
(14) The aim of this paper is to demonstrate that the problems which arise from simultaneously developing regulatory and competitive approaches to health care cost containment can be solved, if recognized, and that those problems deserve more systematic investigation than they have so far received.
(15) In general, air from the mediastinum far more often enters the left pleural cavity than the right one.
(16) In the far east is the arid, depressed country leading down Hell’s Canyon, which bottoms out at the Snake River, which the wolves crossed when they moved from Idaho, and which they now treat more as a crosswalk than a barrier.
(17) We demonstrated that while the protein was incorporated into the cell layer at 6, 24, 48, and 72 hr, a far greater amount was secreted into the media.
(18) Still, even as unknowable as this decision may be for him, as any decision is, really, he is far more qualified to understand his desires and goals that would inform that decision than anyone else is.
(19) They include the Francoist slogan "Arriba España" and the yoke-and-arrows symbol of the far right Falange, whose members killed the women.
(20) For each of the goals, some were far from complying.