(1) Patient plasma samples demonstrated evidence of marked complement activation, with 3-fold elevations of C3a desArg concentrations by the 8th day of therapy.
(2) 5-Azacytidine (I) stability was increased approximately 10-fold over its stability in water or lactated Ringer injection by the addition of excess sodium bisulfite and the maintenance of pH approximately 2.5.
(3) Radioligand binding studies revealed the presence of a single class of high-affinity (Kd = 2-6 X 10(-10) M) binding sites for ET-1 in both cells, although the maximal binding capacity of cardiac receptor was about 6- to 12-fold greater than that of vascular receptor.
(4) The enzyme was solubilized by Triton X-100 and purified approximately 480-fold by gel filtration and affinity chromatography on alanine methyl ketone-AH-Sepharose 4B.
(5) The DNA untwisting enzyme has been purified approximately 300-fold from rat liver nuclei.
(6) IP3 increased 1.7-fold and IP2 1.6-fold after 20 and 40 s, respectively.
(7) Short incubations with heparin (5 min) caused a release of the enzyme into the media, while longer incubations caused a 2-8-fold increase in net lipoprotein lipase secretion which was maximal after 2-16 h depending on cell type, and persisted for 24 h. The effect of heparin was dose-dependent and specific (it was not duplicated by other glycosaminoglycans).
(8) The following conclusions emerge: (i) when the 3' or the 3' penultimate base of the oligonucleotide mismatched an allele, no amplification product could be detected; (ii) when the mismatches were 3 and 4 bases from the 3' end of the primer, differential amplification was still observed, but only at certain concentrations of magnesium chloride; (iii) the mismatched allele can be detected in the presence of a 40-fold excess of the matched allele; (iv) primers as short as 13 nucleotides were effective; and (v) the specificity of the amplification could be overwhelmed by greatly increasing the concentration of target DNA.
(9) Epicanthal folds were present in 46%, mongoloid slanting of the lids in 72% of cases.
(10) The estimated DNA compaction ratio (approximately 3-fold) is consistent with a significant degree of nucleosome unfolding in the hyperstimulated BR genes.
(11) Two hours after refeeding rats fasted for 48 h, ODC activity increased 40-fold in mucosa from the intact jejunum and 4-fold in the mucosa of the bypassed segments.
(12) Transfection of the treated DNA into SOS-induced spheroplasts results in an increase in mutagenesis as great as 50-fold.
(13) ACh released from the vesicular fraction was about 100-fold more than could be accounted for by miniature end-plate potentials; possible causes of this overestimate are discussed.
(14) In strains completely deleted for galR, the gene which encodes the Gal repressor, the operon is derepressed by only 10-fold without an inducer.
(15) The amount of water, creatinine, electrolytes, proteins, and enzymes were higher during the day (up to three fold, p always less than 0.05), while equal amounts of amino acids were excreted in the day and the night period.
(16) TNBS reacts to an extremely small extend with hemoglobin over the concentration range 0.4 to 4 mM whereas FDNB reacts with hemoglobin to a very large extent (50 fold more than TNBS).
(17) Rates of PC in vitro metabolism by liver and kidney cytosolic cysteine conjugate beta-lyases (beta-lyases) were similar, but metabolism by renal mitochondrial beta-lyase occurred at a 3-fold higher rate than the rate obtained with hepatic mitochondrial beta-lyase.
(18) Dietary factors affect intestinal P450s markedly--iron restriction rapidly decreased intestinal P450 to beneath detectable values; selenium deficiency acted similarly but was less effective; Brussels sprouts increased intestinal AHH activity 9.8-fold, ECOD activity 3.2-fold, and P450 1.9-fold; fried meat and dietary fat significantly increased intestinal EROD activity; a vitamin A-deficient diet increased, and a vitamin A-rich diet decreased intestinal P450 activities; and excess cholesterol in the diet increased intestinal P450 activity.
(19) On the other hand, if we correct for the population of HMM with degraded light chain 2, the difference in the binding constants in the presence and absence of Ca2+ may be as great as 5-fold.
(20) The gene, which is located at chromosome XIII, is transcribed as a mRNA of about 2.7 kilobases, and the amount of message has been found to increase 3- to 4-fold during the culture.
Seam
Definition:
(n.) Grease; tallow; lard.
(n.) The fold or line formed by sewing together two pieces of cloth or leather.
(n.) Hence, a line of junction; a joint; a suture, as on a ship, a floor, or other structure; the line of union, or joint, of two boards, planks, metal plates, etc.
(n.) A thin layer or stratum; a narrow vein between two thicker strata; as, a seam of coal.
(n.) A line or depression left by a cut or wound; a scar; a cicatrix.
(v. t.) To form a seam upon or of; to join by sewing together; to unite.
(v. t.) To mark with something resembling a seam; to line; to scar.
(v. t.) To make the appearance of a seam in, as in knitting a stocking; hence, to knit with a certain stitch, like that in such knitting.
(v. i.) To become ridgy; to crack open.
(n.) A denomination of weight or measure.
(n.) The quantity of eight bushels of grain.
(n.) The quantity of 120 pounds of glass.
Example Sentences:
(1) It seams rational to proceed to an earlier total correction in these cases when well defined criteria are fullfilled, as the mortality figures of the palliative and corrective procedures have a tendency to reach each other: (3,2 versus 5,7%).
(2) Osteomalacia is characterized by large osteoid seams and a preserved volume of bone trabeculae.
(3) A sclerotic border and osteoid seams were noted, two features that seem not to have been previously reported in early lesions.
(4) Given the Panahi situation, it seems almost appropriate that this year's festival has been quite downbeat with films mining the darker seams of the human condition.
(5) While the functional significance of the seams remains unknown and their specific composition clearly requires further study, it is likely that they represent important functional (e.g., viscoelastic) or biological (e.g., nutritional) subdivisions of ligament substance.
(6) 1.59pm BST 32nd over: Sri Lanka 89-2 (Jayawardene 11, Sangakkara 22) A jaffa from Plunkett from round the wicket beats Sangakkara all ends up – it was angled in on middle stump, then seamed away to beat the outside edge.
(7) But then a mismanaged clean-up in an underground garbage dump ignited a seam of anthracite eight miles long that proved impossible to extinguish.
(8) Carefully pull the frayed seam over the original seam line and pin in place.
(9) The histological study of the tibiae showed decreased mineralization with narrower trabeculae and enlarged osteoid seams; bone resorption at the inner surface was also significantly decreased.
(10) The amount of osteoid and the length of the osteoid seams were normal, whereas the mean width of the osteoid seams was decreased.
(11) A double white line parallel to the lateral ribs produced by the double seam of the bag distinguishes this artifact from a true pneumothorax.
(12) Calcification rate in the cortical bone of the tibia was reduced with a parallel reduction in endosteal osteoid seam width.
(13) It shows the costs in 1979 included £464 spent on replacing linen, £39 on "sewing carpet seams", £19 on an ironing board and £527 on cleaning carpets.
(14) In infants, human femoral arteries display seam-like internal elastic lamina (IEL) covered with endothelium on the luminal side and with smooth muscle cells (SMC) on the medial side.
(15) The second minor discontinuity to appear is planar (seam), shown here in a dryolestid eupantothere.
(16) (5) The transfer function at the bone seams and thinner areas of the bones was insufficient for modal analysis of the facial region and total cranial bone of the human dry skull.
(17) The seams are filled with subunits that appear to bind the flaps together.
(18) Crystallization of bone salt is severely impaired and an osteomalacia-like picture may be produced with decreased osteoblastic activity, widened growth plates, excessive osteoid seams and short, thickened bones.
(19) The complication rate of laparoscopic cholecystectomy in the hand of a well trained surgeon seams to be comparable or even smaller than in conventional procedure.
(20) Couple or individual reaction after genetic counselling in case of Recklinghausen disease seams us to be very different according to the patients and for a patient according to the moment of counseling.