(n.) One who founds, establishes, and erects; one who lays a foundation; an author; one from whom anything originates; one who endows.
(n.) One who founds; one who casts metals in various forms; a caster; as, a founder of cannon, bells, hardware, or types.
(v. i.) To become filled with water, and sink, as a ship.
(v. i.) To fall; to stumble and go lame, as a horse.
(v. i.) To fail; to miscarry.
(v. t.) To cause internal inflammation and soreness in the feet or limbs of (a horse), so as to disable or lame him.
(n.) A lameness in the foot of a horse, occasioned by inflammation; closh.
(n.) An inflammatory fever of the body, or acute rheumatism; as, chest founder. See Chest ffounder.
Example Sentences:
(1) The PUP founder made the comments at a voters’ forum and press conference during an open day held at his Palmer Coolum Resort, where he invited the electorate to see his giant robotic dinosaur park, memorabilia including his car collection and a concert by Dean Vegas, an Elvis impersonator.
(2) Also, it is often the case that trustees or senior leadership are in said positions because they have personal relationships with the founder.
(3) The committee is chaired by John Thompson, the board's lead independent director, and includes Microsoft founder and chairman, Bill Gates, as well as other board members Chuck Noski and Steve Luczo.
(4) The first decades of this Institute were shaped by the assistant of Robert Koch, Friedrich Loeffler (1852-1915), an important microbiologist and one of the founders of virology.
(5) Shannon Watts, founder of Moms Demand Action, welcomed Target’s shift in policy.
(6) (Observer, June 2013) Nathalie Kosciusko-Morizet , 40 Current job: MP Nicknames: The harpist, "Madame Condescendante" (Bertrand Delanoë), "L'emmerdeuse" (Pain in the neck – Jacques Chirac) Campaign slogan: Une nouvelle énergie pour les Parisiens (A new energy for Parisians) Born: Paris Family: Daughter of a local mayor, granddaughter of a former French ambassador and great-granddaughter of one of the founder members of the French Communist party.
(7) He was indicted on weapons charges and accused of plotting robberies and the assassination of the Southern Poverty Law Center’s founder.
(8) Co-founder Cyndi Anafo’s mother used to run a Ghanaian grocery in the covered market that has recently been rebranded Brixton Village, a target destination for food tourists and wealthy Londoners.
(9) The director of the Museum at Checkpoint Charlie, Alexandra Hildebrandt, keeps a tally started by her late husband Rainer, the museum’s founder, which currently lists 1,720 victims.
(10) One of Prime’s founder members, Linklaters, provides tutoring, mentoring, work experience, and careers events to 2,500 young people in Hackney each year through its Realising Aspirations programme , according to a company spokesperson.
(11) Lyft co-Founder and president John Zimmer and GM president Dan Ammann say the two companies began serious discussions about three months ago.
(12) I want to raise awareness about the number of people who now feel afraid on our streets and map areas where people at risk can feel safest,” said the site’s founder, Hanna Thomas.
(13) In 1995, Bill Gates, founder and CEO at Microsoft, reportedly paid The Rolling Stones $3m (£1.9m) for the rights to use Start Me Up to launch Windows 95.
(14) Sir Ken Morrison, supermarkets Jersey trusts protect the billion-pound wealth of the 83-year-old Bradford-born Morrisons supermarket founder and a large number of his family members.
(15) Responding quickly, whatever the channel, is one of the most important things when it comes to how happy clients feel about the interaction they’ve had,” said Simon Hay, co-founder of online learning platform Firefly .
(16) The windfalls - which it declined to disclose - for its founders may not quite match the sums paid to the creators of YouTube and MySpace but the $280m deal is a welcome pay off for a project that started out from one room in Whitechapel, east London .
(17) The 61-year-old Canadian, who was one of the original founders of Greenpeace , was arrested last Sunday at Frankfurt airport at the request of Costa Rica, which wants to see him extradited over a 10-year-old charge of "violating ships traffic".
(18) The list is split between on and off-screen talent, including Sherlock producer Sue Vertue, the writer of Last Tango in Halifax and Happy Valley, Sally Wainwright, and Elisabeth Murdoch , founder of MasterChef producer Shine.
(19) That “social enterprise” is just a figleaf, which canny, profit-driven companies can manipulate (Emma Harrison, founder of A4e, famously used to call it a “social purpose company” before the Advertising Standards Authority, of all people, put a stop to it ).
(20) In a letter to potential investors, Groupon's co-founder and chief executive, Andrew Mason, warned future growth could come at the expense of profit.
Progenitor
Definition:
(n.) An ancestor in the direct line; a forefather.
Example Sentences:
(1) The effects of in vivo administration of native prostaglandin E2 (PGE) on the cycling status of the granulocyte-monocyte progenitor cell (CFU-GM) were examined in a mouse model.
(2) In healthy persons the supernatant of lymphocytes preincubated with PHA and ALG was found to show a stimulating effect to clonogenic properties of marrow progenitors, the mentioned effect being not in proportion to the concentration value.
(3) We therefore think that the detailed examination of CALLA(-) non-T non-B ALL cells using myeloid specific antibodies is helpful in clarifying the characteristics of myeloid precursors and the common bipotential stem cell of lymphoid and myeloid progenitors.
(4) The high levels of circulating progenitor cells in ALL and CLL patients clearly distinguish them from other cytopenic hematological malignancies, in which decreased progenitor cell levels have been demonstrated previously (acute myeloid leukemia, hairy cell leukemia).
(5) Studies on proliferation and differentiation of granulocyte-monocyte progenitor cells in Chediak-Higashi syndrome (CHS) were done on a 1-month-old patient, using the soft-agar bone marrow culture technique.
(6) Certain mouse and human hematopoietic progenitor cells also contain an aldehyde dehydrogenase that catalyzes the detoxification of aldophosphamide, but the specific identity of this enzyme remains to be established.
(7) Mouse spleen cells rich in erythroid progenitors were washed free of endogenous Epo and then incubated in the absence of Epo.
(8) The bone marrow differentials and numbers of granulocyte-macrophage progenitors (CFC-GM) were determined after irradiation with 1.5 Gy.
(9) However, the studies on 0-2A progenitor cells were carried out in bulk cultures of optic nerve, and so it was possible that other cell-cell interactions were required for differentiation in culture.
(10) In culture, GY30 cells sustain the production of granulocyte-macrophage progenitor cells (GM-CFU) but fail to support the survival of pluripotential stem cells (CFU-S).
(11) The development of T cells from stem (progenitor) cells to effector cells results from a two-wave process of proliferation and differentiation.
(12) No chemical or immunological differences were observed in the cell wall carbohydrate of the noncapsulated streptococcus, 89R50, and that of its capsulated progenitor.
(13) This is exemplified in lymphoma cells (chronic lymphocytic leukemia of B or T type, Sezary Syndrome, immunocytoma) that resemble mature and immunocompetent T and B cells, in T cell acute lymphoblastic leukemia (T-ALL) (equivalent to thymus cells) and in non-T ALL (corresponding to lymphoid progenitor cells in the bone marrow).
(14) We studied MDS-associated inhibitory activity, which inhibited colony formation in vitro of granulocyte-macrophage progenitors (CFU-GM).
(15) In contrast, populations containing BFUe yielded a striking (sixfold for CFUe; 23-fold for e-clusters) expansion of late progenitors in the presence of Epo.
(16) The stem cell loss immediately following 55Fe injection is in our interpretation caused by rapid differentiation along the erythroid pathway in a response that involves all progenitor populations.
(17) We report here that human IL-6 and IL-3 act synergistically in support of the proliferation of progenitors for human blast cell colonies and that IL-1 alpha reveals no synergism with IL-3 when tested against purified human marrow progenitors.
(18) In addition, we have examined the ability of these fibroblasts and their conditioned medium (CM) to induce differentiation of human hemopoietic progenitor cells.
(19) AF and its deacetylated form inhibited the development of macrophage and granulocytic colonies from progenitor cells in human bone marrow even at concentrations less than or equal to 10(-9)M. The disease suppressive activity of AF could result in part from the reduction of cell numbers in arthritic lesions and our findings provide a mechanism for this possibility.
(20) Spontaneously hypertensive rats (SH) with an increased number of red blood cells (RBC), microcytosis, and normal hemoglobin (Hb) concentration were used to study the effect of different manipulations of the erythron on erythropoietin production and on erythroid progenitor proliferation by bone marrow cells in order to gain insight regarding the regulation of erythropoiesis.