(n.) A spout projecting from the roof gutter of a building, often carved grotesquely.
Example Sentences:
(1) Their intellect is normal and they have no gargoyle-like features.
(2) Bill Nighy plays the king of the demons; Miranda Otto the gargoyle queen.
(3) beta-Mannosidase deficiency was demonstrated in fibroblasts of a girl who showed severe psychomotor retardation, bone deformities and gargoylism and recurrent skin and respiratory infections and who died at 20 years of age from bronchopneumonia.
(4) In various tissues from patients with gargoylism, deficiency of beta-galactosidase A could be demonstrated.
(5) The high level of mannose in the liver from gargoylism patients seems to indicate storage of glycopeptide, adding a new group of substances to those known to be stored in gargoylism.
(6) An autopsy case of a 19-year-old boy who had shown typical gargoyle features, strictly consistent with mucopolysaccharidosis type II (Hunter's syndrome) was reported.
(7) The reversed conditions could be caused by the difference of increased aMPS; i.e., dermatan sulfate B or heparitin sulfate in gargoylism, on the contrary, dermatan sulfate A and C or hyaluronic acid in Marfan syndrome.
(8) An adult patient with macular cherry-red spots, a gargoyle-like physical appearance, cerebellar ataxia, myoclonus, convulsive seizures, and pyramidal tract signs showed a profound deficiency of beta-galactosidase in liver and brain.
(9) The patient had a gargoyle-like face, bone change with cherry-red spot and absence of mucopolysacchariduria, and moreover accompanied by hereditary thrombocytopathy and color blindness.
(10) The nature of the basic defect in gargoylism is discussed.
(11) It must however be mentioned that the most frequent mucopolysaccharidosis, Sanfilippo's disease, and other forms of mucopolysaccharidoses (MPSoses) are not showing gargoylism.
(12) As grim as a gargoyle, craggy as a crag, jaw set in steel – even the famous smirk was well hidden behind the scowl.
(13) The present paper describes 3 out of a total of 9 siblings, aged 9, 17, and 18, with the following symptoms: gargoyle-like facial features, clouding of the cornea in both eyes, dysostosis multiplex, slightly impaired intelligence, hepatosplenomegaly, umbilical hernia, and increased secretion of mucopolysaccharides in the urine, in particular dermatan and heparan sulfate.
(14) Cellulose acetate electrophoresis differentiated clearly between the two major forms of gargoylism, the Hurler and Sanfilippo syndromes, but differentiation between the Hurler, Hunter, and Scheie syndromes was more difficult on electrophoretic data alone.
(15) The samples analyzed were obtained from control subjects, patients with gargoylism, and patients with a few other kinds of storage disorders.
(16) Studies in the morphology, histochemistry, and ultrastructure of the cerebellum, with special reference to the Purkinje cell dendrites, have been undertaken in eight cases of gargoylism.
(17) Still though, the obsession with personality, the grand gargoyles of the dugout over, say, tactics and development remains.
(18) In newspapers, cartoons squat like gargoyles on top of the columns, and while you nibble your way through the columnists' prose for several minutes, you swallow the cartoon whole in seconds.
(19) An autopsy case of a 9 years and 5 months old gargoyle girl diagnosed as Sanfilippo B syndrome by the biochemical demonstration of a large amount of heparan sulfate in urine and some organs and of deficiency of alpha-N-acetyl-D-glucosaminidase in the liver and brain was reported.
(20) A 17-year-old patient clinically manifesting gargoyle face, dwarfism, skeletal bone deformity, mild mental retardation and benign course was presented.
Hag
Definition:
(n.) A witch, sorceress, or enchantress; also, a wizard.
(n.) An ugly old woman.
(n.) A fury; a she-monster.
(n.) An eel-like marine marsipobranch (Myxine glutinosa), allied to the lamprey. It has a suctorial mouth, with labial appendages, and a single pair of gill openings. It is the type of the order Hyperotpeta. Called also hagfish, borer, slime eel, sucker, and sleepmarken.
(n.) The hagdon or shearwater.
(n.) An appearance of light and fire on a horse's mane or a man's hair.
(v. t.) To harass; to weary with vexation.
(n.) A small wood, or part of a wood or copse, which is marked off or inclosed for felling, or which has been felled.
(n.) A quagmire; mossy ground where peat or turf has been cut.
Example Sentences:
(1) The hag gene and adjacent regions of the B. subtilis chromosome were restriction mapped, and the nucleotide sequence was determined.
(2) (i) The hag gene was expressed constitutively in Fla+ cells.
(3) Group B mutants were segregated from the hag locus and appeared closely linked to the phage adsorption site gene (gtaA), and group C was only loosely linked to hisA1 and thus far contains only one mutant.
(4) The addition of 3M KCl-extracted donor antigen (HAg) to immunosuppressive therapy with 16 Gy total lymphoid irradiation produces a significantly higher fraction of Wistar-Furth (WFu) recipients displaying indefinite survival of heterotopic buffalo (BUF) heart allografts, namely 80 versus 20%.
(5) The atherometric system proved to be useful to distinguish between HAG and LAG.
(6) Lowering the extracellular Ca2+ concentration to 6 or 50 microM attenuated markedly the glycogenolytic and haemodynamic responses to HAG; efflux of Ca2+ from the liver was not observed in response to HAG.
(7) The chromosomal locus containing the wild-type flagellin allele was replaced with a defective allele of the gene (delta hag-633) that contained a 633-base-pair deletion.
(8) (iii) The hag gene was expressed in mutants with flaS, flaT, flaU, and flbC defects.
(9) HAG and HAgC were observed to collect in coated pits whereas wild-type HA was excluded from those structures.
(10) lambda pflaL1 carries all nine fla genes at 43 min, and lambda pflaH14 carries hag and two fla genes at 42.5 min.
(11) Data derived from the responses of 69 adults to the Cornell Medical Index (CMI) indicate that there are no significant differences in psychological or physical illness complaints between adults who have experienced the Old Hag and adults who have not had this experience.
(12) In the presence of chloroquine, which inhibits the exit of receptors from endosomes, HAG and HAgC accumulated in intracellular vesicles.
(13) The positive inotropic responses and coronary perfusion pressure effects elicited by PMA and PDBu were largely prevented by the addition of the PKC inhibitors H7 (6 nM) or HAG (10 nM); however, these drugs were without effect on the negative inotropic response to higher concentrations of both PKC-activating (PMA, PDBu) and non-PKC-activating (alpha PDD, 4 alpha-phorbol) phorbol compounds.
(14) The patients were classified according to the primary cause of death, as high atherosclerotic (HAG) or low atherosclerotic groups (LAG), comprising 1,171 and 872 cases, respectively.
(15) The mononitrobenzylidene-HAGs were more active than the dinitrobenzylidene-HAG compound.
(16) Heat aggregated human (HAG) IgG pretreated with total rheumatoid factors isolated from the serum of rheumatoid arthritis patients showed decreased superoxide generation enhancing activity as compared with HAG pretreated with buffer alone.
(17) Sequencing of this hag gene revealed that it encodes a protein of 272 amino acids (M(r) 29,995).
(18) These results suggested that 5-HT does not release PRL through a direct pituitary action, and that the effect observed in HAG animals could be mediated through the release of a PRL-releasing factor after 5-HT administration.
(19) Of eighteen such transductants sixteen failed to show phase variation, and on transduction back to Salmonella each structural gene for a phase-2 flagellin (or at least for its antigenically determinant part) now behaved as an allele of H1, presumably in consequence of incorporation in the hag region of the K12 recipient, in place of H1-i ah1.
(20) It was shown that at HAg greater than or equal to 25% the strains used for antigen and antibody generation were closely related and at HAg less than or equal to 6.25% belonged to different subtypes.