(1) We have isolated several gamma-ray-induced mutants (GIMs) of the nontumorigenic HeLa x skin fibroblast hybrid CGL1 that were specifically selected for reexpression of IAP to further investigate the potential linkage between IAP regulation and the putative tumor suppressor locus.
(2) The relaxation rates of the exchangeable guanine imino protons (Gim) in H2O and in 90% D2O show that below 20 degrees C spin-lattice relaxation is exclusively from proton-proton magnetic dipolar interactions while proton-nitrogen interactions contribute about 30% to the spin-spin relaxation.
(3) These stimulate the processes of myeloid precursor proliferation directly (by means of lymphokines) and in cooperation with monocytes-macrophages of GIM.
(4) The relaxation rates of the Gim, C-H5, and C-H6 in B- and Z-form poly(dG-dC).poly(dG-dC) cannot be explained by assuming the DNA behaves as a rigid rod.
(5) Gonadotrophin-inhibiting material (GIM) was able to inhibit the binding of 125I-hCG to rat Leydig cells, suggesting that its inhibiting properties are due to its ability to complete for the hCG binding sites on Leydig cells.
(6) The observation that the spin-lattice relaxation is nonexponential and that the initial spin-lattice relaxation rate of the Gim, G-H8 and C-H6 protons depends on the selectivity of the exciting pulse shows that spin-diffusion dominates the spin-lattice relaxation.
(7) However, studies with tumor reconstitutes of the GIMs and transfection studies with an IAP complementary DNA expression vector indicate that high IAP expression alone is not sufficient to confer rapid tumor growth.
(8) Measurements of the 1H spin-lattice (R1) and spin-spin (R2) relaxation rates of the exchangeable thymine (Tim) and guanine (Gim) imino protons have been used to probe the internal dynamics of the B and Z-forms of poly[d(A-br5C).d(G-T)] and the mechanism of the B-Z transition.
(9) The GIMs have a wide range of cell morphology and level of IAP expression (nearly a factor of 40).
(10) The effect of GIM on hCG-induced adenylate cyclase activation and testosterone production was also studied.
(11) Conversion to the Z-form by addition of 4.5 M-NaCl dramatically reduces both the Tim and Gim exchange rates (estimated to be less than 2 s-1 at 70 degrees C).
(12) Binding of fluorescein isothiocyanate-tagged GIM to Leydig cells was also seen.
(13) The tumorigenicity of the GIMs was examined by s.c. injection into nude mice and all were found to be tumorigenic.
(14) The B and Z-forms of poly[d(A-br5C).d(G-T)] coexist in 4.6 M-NaCl at 45 degrees C. Due to slow exchange, two sets of Tim and Gim resonances are observed and can be assigned to the B and Z conformations (the chemical shifts are, respectively, Tim = 13.4, 14.1 p.p.m.
(15) In the second study a combination of music and imagery was examined by randomly assigning subjects to one of five groups: self-generated imagery with music (SIM), guided imagery with music (GIM), self-generated imagery without music (SI), guided imagery without music (GI), or no-treatment control.
(16) The tumor volume-doubling time is in the range of 4 to 8 days for all the cell lines; however, the lag time to reach 500 mm3 tumor volume was significantly longer when the GIM IAP activity was low (less than 20% relative activity), suggesting perhaps that there is a threshold level of IAP expression required for tumor formation and selection for high IAP expression in vivo.
(17) The increased number of committed precursor cells of erythro- and granulomonocytopoiesis, morphologically differentiated elements and enhancing colony-stimulating and erythropoietic activities of GIM cells origin were shown as well.
(18) At elevated temperature, R1 for both Tim and Gim in the B conformation is dominated by exchange with the solvent, with Tim exchanging more rapidly than Gim.
Gimp
Definition:
(a.) Smart; spruce; trim; nice.
(n.) A narrow ornamental fabric of silk, woolen, or cotton, often with a metallic wire, or sometimes a coarse cord, running through it; -- used as trimming for dresses, furniture, etc.
(v. t.) To notch; to indent; to jag.
Example Sentences:
(1) British Cycling, Will’s Wheels and the curious case of 2,200 pieces of GB kit Read more Drake said: “I have never been made aware, formally or informally, of any allegation that Shane Sutton had used the offensive term ‘gimps’ in reference to Paralympic athletes prior to the media reports of the past few days.
(2) I do like people.” What they say “At the risk of ruining the honourable gentleman’s reputation as Thatcher’s gimp – I mean toy boy – may I enormously commend him for the work he has done as [select] committee chair for the past 10 years” – Chris Bryant MP
(3) PT: Photoshop is standard; though it certainly won’t hurt if you get good with GIMP, which is completely free.
(4) But BrewDog got to denounce Diageo as “a band of dishonest hammerheads and dumb-ass corporate freaks”, and to affirm that the incident showed “just how scared and jealous the gimp-like establishment are of the craft beer revolutionaries”.
(5) As well as woozily offering Mark Ronson a sip of his gin, we also got to witness him confessing his love for gimp masks; playing “ hide the banana ”; and an excruciating “bit” with blind tenor Andrea Bocelli in which he stammered “Nice to, erm, see you”.
(6) A kind of unshaven, post-watershed, post-divorce and redundancy Johnny Bravo whose style inspiration sits somewhere between matador and gimp.
(7) The localization and chemical characteristics of two Golgi integral membrane proteins (GIMPs) have been studied using monoclonal antibodies.
(8) Both GIMPs are glycoproteins that contain N- and O-linked carbohydrates.
(9) In an email to the Guardian Mellor said: “‘Get those Fucking Gimps’ was a phrase that was used by Shane [Sutton] and I confirm was ignored by Ian Drake when raised by me.” Mellor also stated that in his view the Paralympic athletes were discriminated against when it came to resources, for example travelling at times without a doctor or, on one occasion, being asked to scrap a training camp when the able‑bodied team’s budget fell short.
(10) Documents from Mellor’s evidence shown to the Guardian cited an episode in which Sutton was described as coming to the coach’s office and shouting “get those fucking gimps off the track”.
(11) It’s tempting to compare them to Late Night Gimp Fight, their predecessors as the fringe’s go-to troupe for “blood, poo and bumholes” (their words) comedy.
(12) But he was left with little option but to resign after he was also accused of calling members of Britain’s hugely successful Paralympic cycling squad “wobblies” and “gimps”.
(13) The young sketch troupe Late Night Gimp Fight were entirely unapologetic about their scene at Edinburgh last month, in which Sleeping Beauty wasn't kissed awake by her prince, but raped instead.