(1) We have isolated several gamma-ray-induced mutants (GIMs) of the nontumorigenic HeLa x skin fibroblast hybrid CGL1 that were specifically selected for reexpression of IAP to further investigate the potential linkage between IAP regulation and the putative tumor suppressor locus.
(2) The relaxation rates of the exchangeable guanine imino protons (Gim) in H2O and in 90% D2O show that below 20 degrees C spin-lattice relaxation is exclusively from proton-proton magnetic dipolar interactions while proton-nitrogen interactions contribute about 30% to the spin-spin relaxation.
(3) These stimulate the processes of myeloid precursor proliferation directly (by means of lymphokines) and in cooperation with monocytes-macrophages of GIM.
(4) The relaxation rates of the Gim, C-H5, and C-H6 in B- and Z-form poly(dG-dC).poly(dG-dC) cannot be explained by assuming the DNA behaves as a rigid rod.
(5) Gonadotrophin-inhibiting material (GIM) was able to inhibit the binding of 125I-hCG to rat Leydig cells, suggesting that its inhibiting properties are due to its ability to complete for the hCG binding sites on Leydig cells.
(6) The observation that the spin-lattice relaxation is nonexponential and that the initial spin-lattice relaxation rate of the Gim, G-H8 and C-H6 protons depends on the selectivity of the exciting pulse shows that spin-diffusion dominates the spin-lattice relaxation.
(7) However, studies with tumor reconstitutes of the GIMs and transfection studies with an IAP complementary DNA expression vector indicate that high IAP expression alone is not sufficient to confer rapid tumor growth.
(8) Measurements of the 1H spin-lattice (R1) and spin-spin (R2) relaxation rates of the exchangeable thymine (Tim) and guanine (Gim) imino protons have been used to probe the internal dynamics of the B and Z-forms of poly[d(A-br5C).d(G-T)] and the mechanism of the B-Z transition.
(9) The GIMs have a wide range of cell morphology and level of IAP expression (nearly a factor of 40).
(10) The effect of GIM on hCG-induced adenylate cyclase activation and testosterone production was also studied.
(11) Conversion to the Z-form by addition of 4.5 M-NaCl dramatically reduces both the Tim and Gim exchange rates (estimated to be less than 2 s-1 at 70 degrees C).
(12) Binding of fluorescein isothiocyanate-tagged GIM to Leydig cells was also seen.
(13) The tumorigenicity of the GIMs was examined by s.c. injection into nude mice and all were found to be tumorigenic.
(14) The B and Z-forms of poly[d(A-br5C).d(G-T)] coexist in 4.6 M-NaCl at 45 degrees C. Due to slow exchange, two sets of Tim and Gim resonances are observed and can be assigned to the B and Z conformations (the chemical shifts are, respectively, Tim = 13.4, 14.1 p.p.m.
(15) In the second study a combination of music and imagery was examined by randomly assigning subjects to one of five groups: self-generated imagery with music (SIM), guided imagery with music (GIM), self-generated imagery without music (SI), guided imagery without music (GI), or no-treatment control.
(16) The tumor volume-doubling time is in the range of 4 to 8 days for all the cell lines; however, the lag time to reach 500 mm3 tumor volume was significantly longer when the GIM IAP activity was low (less than 20% relative activity), suggesting perhaps that there is a threshold level of IAP expression required for tumor formation and selection for high IAP expression in vivo.
(17) The increased number of committed precursor cells of erythro- and granulomonocytopoiesis, morphologically differentiated elements and enhancing colony-stimulating and erythropoietic activities of GIM cells origin were shown as well.
(18) At elevated temperature, R1 for both Tim and Gim in the B conformation is dominated by exchange with the solvent, with Tim exchanging more rapidly than Gim.
Gin
Definition:
(n.) Against; near by; towards; as, gin night.
(conj.) If.
(v. i.) To begin; -- often followed by an infinitive without to; as, gan tell. See Gan.
(n.) A strong alcoholic liquor, distilled from rye and barley, and flavored with juniper berries; -- also called Hollands and Holland gin, because originally, and still very extensively, manufactured in Holland. Common gin is usually flavored with turpentine.
(n.) Contrivance; artifice; a trap; a snare.
(n.) A machine for raising or moving heavy weights, consisting of a tripod formed of poles united at the top, with a windlass, pulleys, ropes, etc.
(n.) A hoisting drum, usually vertical; a whim.
(n.) A machine for separating the seeds from cotton; a cotton gin.
(v. t.) To catch in a trap.
(v. t.) To clear of seeds by a machine; as, to gin cotton.
Example Sentences:
(1) The Macassans traded iron, tobacco, cloth and gin for access to Yolngu waters.
(2) For now, he leans on the bar – a big man, XL T-shirt – and, in a soft Irish accent, orders himself a small gin and tonic and a bottle of mineral water.
(3) Gin was popularised in the UK via British troops who were given the spirit as “Dutch courage” during the 30 years’ war.
(4) The Gin DNA invertase of bacteriophage Mu carries out processive recombination in which multiple rounds of exchange follow synaptic complex formation.
(5) It's a small sample, consisting of the folk on the train to Kings Cross this lunchtime, but your MBM correspondent saw: several gentlemen swilling from cans of San Miguel and talking excitedly about the World Cup; two blonde women in frankly disorienting 1980s style football shorts waving flags; and a bloke sitting on his own necking a tin of pre-mixed gin and tonic.
(6) They don’t have to wait three or four years for what may or may not be the marginal difference they make to the whisky product.” Miller’s gin now sells more than all his whisky products put together, making up 80% of total sales.
(7) I still have a few pints of gin and tonic before I go onstage but nothing stupid."
(8) It is a lot like the craft beer where we’ve seen big brands say ‘it’s time we bought these brands before they become big competition’.” He said the buyout of the craft gin distiller Monkey 47 by Pernod Ricard in January marked the beginning of a trend that was likely to escalate, although there were few craft gin makers who have reached any serious scale.
(9) To prepare the data base of the occlusal surface of tooth crown, the data of tooth crown above the gingival line of 7 molar were also output by the "GIN-M" program.
(10) The very thought is enough to get older Tory MPs spluttering into their gin this weekend – but it's probably a factor and a very zeitgeisty one.
(11) In the presence of purified Gin FIS is the only additional protein required for efficient inversion.
(12) The intriguing finding that the DNA invertase Gin has the same catalytic center as the DNA resolvases that promote deletions without recombinational enhancer and host factor FIS is discussed.
(13) This was soon accompanied by other “medicinal” drinks such as the gimlet, to avoid scurvy on ship, and pink gin, which was said to help seasickness.
(14) Both of the alcohol-containing drinks caused mild-to-moderate inebriation, but gin and slimline tonic had no significant effect on either blood-glucose or plasma-insulin levels.
(15) Cameron took his jacket off and sipped from the half pint glasses of water – gin?
(16) By 1849 gin was respectable enough to be included in the Fortnum and Mason catalogue for the first time.
(17) Drinks that are mostly ethanol, such as gin and vodka, give fewer hangovers (but not none) than those full of congeners, such as red wine or whisky.
(18) While the opening tranche of "tales" derive from the work of forgotten contemporary humorists, the pieces of London reportage that he began to contribute to the Morning Chronicle in autumn 1834 ("Gin Shops", "Shabby-Genteel People", "The Pawnbroker's Shop") are like nothing else in pre-Victorian journalism: bantering and hard-headed by turns, hectic and profuse, falling over themselves to convey every last detail of the metropolitan front-line from which Dickens sent back his dispatches.
(19) Four types of cultured cell (Gin-1, Chang Liver, HEP-2 and L-929) were used in vitro to determine the cytotoxicity of 12 Chinese-Japanese Dental Casting Alloys from cell recovery ability.
(20) It is 19 years since Malton joined Alcoholics Anonymous (AA) and had her last gin and tonic.