(n.) A constitutional disease, occurring by paroxysms. It consists in an inflammation of the fibrous and ligamentous parts of the joints, and almost always attacks first the great toe, next the smaller joints, after which it may attack the greater articulations. It is attended with various sympathetic phenomena, particularly in the digestive organs. It may also attack internal organs, as the stomach, the intestines, etc.
(n.) A disease of cornstalks. See Corn fly, under Corn.
(n.) Taste; relish.
Example Sentences:
(1) In 8 patients with gout and 11 patients with pseudogout synovial fluid and small tissue specimens could be obtained with the aid of the Parker-Pearson needle.
(2) Both patients are likely to be sporadic cases of familial nephropathy with gout, an autosomal dominant disease, due to a new mutation.
(3) Conversely, crystalline protein binding may be a critical factor in the pathogenesis of gout, and the presence of abnormal proteins in RA could protect against gout.
(4) Tissue degeneration in gout clearly follows (tophaceous) crystal deposition.
(5) Five of our 7 patients had a positive family history of tics, and 2 a confirmed family history of gout.
(6) A 30-year-old man had a recurrent painful calf swelling associated with gout that mimicked thrombophlebitis and possibly muscle tear.
(7) Sclerosed areas with scarce and plump villi as well as sometimes hyperplastic and polymorphous synovial cell layers could be demonstrated histologically in the tissue specimens of the needle biopsies in cases with gout.
(8) Significantly more treated patients than control subjects showed evidence of a high serum creatinine level, mild hypokalemia, and gout.
(9) A many-year investigation of 254 primary gout patients aged 21 to 78 was carried out to reveal characteristic features of a course of gout under present-day conditions.
(10) The history of saturnine gout is almost as old as civilization itself.
(11) Intra- as well as extracellular crystals could also be demonstrated with the aid of scanning electron microscopy in sediments of synovial fluid in gout and pseudogout.
(12) A study of the level of beta 2-microglobulin (beta 2-MG) in the blood serum and urine was conducted in 67 patients: 22 with chronic pyelonephritis, 13 with gout with renal lesion, 25 with chronic glomerulonephritis (5 without hyperuricemia, 20 with hyperuricemia) and 7 with amyloidosis accompanied mainly by renal lesion.
(13) Naproxen is a useful alternative agent for the treatment of acute gout.
(14) A 65-year-old man with gout and renal dysfunction had taken 1 mg of colchicine daily for 3 years.
(15) In 1988 Abbot could prove that among men, those afflicted by gout as compared to those without gout experienced a 60% excess of coronary heart disease.
(16) The authors presented the results of a 5-year follow-up of 50 gout patients who had been regularly (no less than 3-4 times a year) examined in outpatient clinics.
(17) A high prevalence of gout among workers of the mining industry and early age at the onset of disease suggest probable association of gout with some industrial factors (manganese, tungsten, molybdenum, bismuth).
(18) For the great majority of patients with uncomplicated hypertension, without a previous myocardial infarction, congestive heart failure, diabetes mellitus or gout, thiazide diuretics appear to be both safe and effective antihypertensive agents.
(19) Ten years ago, we studied the clinical and radiographic manifestations of gout in 60 patients and described 3 patterns of disease.
(20) John Harvey Kellogg, the inventor of Corn Flakes, also invented the sunbed, patenting his first device in 1896 – by royal appointment no less, as Edward VII apparently kept one at Windsor Castle for his gout.
Splotch
Definition:
(n.) A spot; a stain; a daub.
Example Sentences:
(1) The Splotch mutant embryo is proposed to be a new animal model for the study of peripheral nerve ensheathment.
(2) Concurrent research has recently characterized Sp2H, a radiation induced mutation at the splotch (Sp) locus, and found alterations in the murine paired box gene, Pax-3, in homozygous Sp2H DNA.
(3) The early development of delayed Splotch mouse embryos was examined histologically using scanning electron microscopy and morphometric techniques.
(4) Studies with the delayed splotch gene tested the hypothesis that offspring with a hereditary defect of neural-tube closure have other, unexpressed CNS defects, which may be elicited by teratological impulses.
(5) Yet grisly pictures on Xinhua's website show a shirtless man covered in purple splotches lying on a hospital bed, his left arm awkwardly splayed across his chest.
(6) The topogenesis of the hindlimb nerves of Splotch homozygous mutant mouse embryos was studied using light and electron microscopy.
(7) Sp1H mice, which have a radiation-induced allele of Splotch with a similar phenotype, were used for this study.
(8) We have used a set of markers newly assigned to the proximal portion of mouse chromosome 1 to characterize the chromosomal segment deleted in the splotch-retarded (Spr) mouse mutant.
(9) A major problem in the study of neural tube defects caused by the splotch (Sp) gene in the mouse has been the identification of gene carriers or potentially affected embryos at an early stage of development, since the gene's effects become visible only late in gestation or after birth.
(10) The splotch (Sp) mouse is a model for both neurulation defects and defects in neural crest cell (NCC) derivatives.
(11) The parameters of the cell cycle were determined in 10-day-old mouse embryos, homozygous for the splotch (Sp) gene, by the radioautographic method with H-3-thymidine.
(12) In this report, rare cases of neural tube defects and tail defects among the offspring of crosses between Splotch (Sp1H) heterozygotes are presented, which are not associated with a neural crest defect.
(13) The Splotch mutant mouse is proposed to be an animal model for persistent truncus arteriosus.
(14) Embryos carrying Sp or its allele splotch-delayed (Spd), have been shown to have delays in neural tube closure, and neural crest cell emigration, as well as a reduction in extracellular space around the neural tube.
(15) In the homozygous state, the splotch (Sp) gene causes spina bifida and exencephaly.
(16) By the 12th day, the posterior neuropore of controls had closed and secondary neurulation was underway; however in delayed Splotch embryos, the neural folds remained widely splayed and epithelium newly formed via secondary neurulation extended that abnormally open configuration to the tip of the tailbud.
(17) Splotch is caused by mutation in the mouse Pax-3 gene.
(18) The septation of the truncus arteriosus and the development of the aortic arch-derived blood vessels was studied in homozygotes of the Splotch mutant allele Sp1H.
(19) Mouse embryos, homozygous for mutations at the Splotch locus, are afflicted with spina bifida and disturbances of neural-crest-derived tissues, e.g.
(20) Embryos obtained from matings of mice heterozygous for the delayed Splotch gene exhibited a high incidence of lumbosacral (25%) or cephalic (7%) neural tube defects.