(1) The patterns observed were: clusters of granules related to the cell membrane; positive staining localized to portions of the cell membrane, and, less commonly, the whole cell circumference.
(2) The extrusion of granules into the intercellular space via exocytosis is frequently observed.
(3) We have previously shown that serotonin is present in secretory granules of frog adrenochromaffin cells; concurrently, we have demonstrated that serotonin is a potent stimulator of corticosterone and aldosterone secretion by adrenocortical cells.
(4) Finally, it could be observed that elevated osmotic pressures reduced the lysis of isolated secretory granules when bicarbonate ions were present in the incubation medium.
(5) In addition, transitional macrophages with both positive granules and positive RER, nuclear envelope, negative Golgi apparatus (as in exudate- resident macrophages in vivo), and mature macrophages with peroxidatic activity only in the RER and nuclear envelope (as in resident macrophages in vivo) were found.
(6) They had no endocrine-like granules and were not associated with nerves or basement membranes.
(7) Electron microscopic immunohistochemistry revealed histamine-immunostaining in granules in a small number of nerve fibers and varicosities.
(8) Results of detailed studies on tissue reactions to Cysticercus bovis in the heart of cattle, together with a comparison of findings in animals with spontaneous and experimental infection, and an evaluation of tissue reactions in relation to the location, morphology and morphogenesis of C. bovis provided evidence for the fact that in general, the response of the heart to the presence of C. bovis was an inflammatory reaction characterized by the origin of a pseudoepithelial border and a zone of granulation tissue.
(9) The presence of a previously unreported dipeptide transport mechanism within blood leukocytes and the selective enrichment of the granule enzyme, DPPI, within cytotoxic effector cells of lymphoid or myeloid lineage appear to afford a unique mechanism for the targeting of immunotherapeutic reagents composed of simple dipeptide esters or amides.
(10) The volume density of glycogen granules in hepatocytes was highest 4 hr after the secretory granules of B cells showed the lowest value.
(11) A new technique to obliterate the mastoid volume or to reduce an old cavity by means of hydroxyapatite granulate is presented.
(12) The data suggest that proinsulin, normally processed in secretory granules and released via the regulated pathway, may also be processed, albeit less efficiently, by the constitutive pathway conversion machinery.
(13) In telecost fishes, the corpuscles of Stannius contain Bowie-stainable granules and a renin-like pressor substance.
(14) Electron microscopy revealed a well-developed rough endoplasmic reticulum, an enlarged Golgi apparatus and many highly electron-dense secretory granules resembling those of Clara cells.
(15) The study confirms that secretin influences pancreatic protein secretion and indicates in addition, that pharmacologic doses of the hormone, have the capacity to block acinar cell zymogen granule release.
(16) Immunoreactions of LTR which were seen in specific granules of neutrophils and monocytes attached to the endothelial cell surface may indicate the onset of endothelial cell damage.
(17) The capacity of granule-cell networks to separate overlapping patterns of activity on their inputs is adequate, with spatial variability in the secretion at synapses, but is improved if there is also temporal variability in the stochastic secretion at individual synapses, although this is at the expense of reliability in the network.
(18) These results suggest that bPAG is probably synthesized by trophoblast binucleate cells and stored in granules prior to delivery into the maternal circulation after cell migration.
(19) CAM, especially CD11c, were also detected in cytoplasmic granules by immunostaining in IL2-activated NK cells.
(20) The outstanding morphologic feature of cortical cells exposed to microunit ACTH concentrations for 40 min was the abundance of electron-dense granules (0.2-0.4 mum).
Mark
Definition:
(n.) A license of reprisals. See Marque.
(n.) An old weight and coin. See Marc.
(n.) The unit of monetary account of the German Empire, equal to 23.8 cents of United States money; the equivalent of one hundred pfennigs. Also, a silver coin of this value.
(n.) A visible sign or impression made or left upon anything; esp., a line, point, stamp, figure, or the like, drawn or impressed, so as to attract the attention and convey some information or intimation; a token; a trace.
(n.) A character or device put on an article of merchandise by the maker to show by whom it was made; a trade-mark.
(n.) A character (usually a cross) made as a substitute for a signature by one who can not write.
(n.) A fixed object serving for guidance, as of a ship, a traveler, a surveyor, etc.; as, a seamark, a landmark.
(n.) A trace, dot, line, imprint, or discoloration, although not regarded as a token or sign; a scratch, scar, stain, etc.; as, this pencil makes a fine mark.
(n.) An evidence of presence, agency, or influence; a significative token; a symptom; a trace; specifically, a permanent impression of one's activity or character.
(n.) That toward which a missile is directed; a thing aimed at; what one seeks to hit or reach.
(n.) Attention, regard, or respect.
(n.) Limit or standard of action or fact; as, to be within the mark; to come up to the mark.
(n.) Badge or sign of honor, rank, or official station.
(n.) Preeminence; high position; as, particians of mark; a fellow of no mark.
(n.) A characteristic or essential attribute; a differential.
(n.) A number or other character used in registring; as, examination marks; a mark for tardiness.
(n.) Image; likeness; hence, those formed in one's image; children; descendants.
(n.) One of the bits of leather or colored bunting which are placed upon a sounding line at intervals of from two to five fathoms. The unmarked fathoms are called "deeps."
(v. t.) To put a mark upon; to affix a significant mark to; to make recognizable by a mark; as, to mark a box or bale of merchandise; to mark clothing.
(v. t.) To be a mark upon; to designate; to indicate; -- used literally and figuratively; as, this monument marks the spot where Wolfe died; his courage and energy marked him for a leader.
(v. t.) To leave a trace, scratch, scar, or other mark, upon, or any evidence of action; as, a pencil marks paper; his hobnails marked the floor.
(v. t.) To keep account of; to enumerate and register; as, to mark the points in a game of billiards or cards.
(v. t.) To notice or observe; to give attention to; to take note of; to remark; to heed; to regard.
(v. i.) To take particular notice; to observe critically; to note; to remark.
Example Sentences:
(1) Herpesviruses such as EBV, HSV, and human herpes virus-6 (HHV-6) have a marked tropism for cells of the immune system and therefore infection by these viruses may result in alterations of immune functions, leading at times to a state of immunosuppression.
(2) Patient plasma samples demonstrated evidence of marked complement activation, with 3-fold elevations of C3a desArg concentrations by the 8th day of therapy.
(3) Following in vitro C activation in NHS by delta IgG, the 40 KD C4d component increased markedly.
(4) However, when cross-linked to anti-CD4 or anti-CD8 antibodies a markedly enhanced proliferation of the corresponding subpopulation is observed.
(5) When chimeric animals were subjected to a lethal challenge of endotoxin, their response was markedly altered by the transferred lymphoid cells.
(6) Increased dietary protein intake led to increased MDA per nephron, increased urinary excretion of MDA, and increased MDA per milligram protein in subtotally nephrectomized animals, and markedly increased the glutathione redox ratio.
(7) Cyclic AMP stimulated phosphorylation by [gamma-32P]ATP of two proteins of apparent Mr = 20,000 and 7,000 that were concentrated in sarcoplasmic reticulum, but the stimulation was markedly dependent on the presence of added soluble cyclic AMP-dependent protein kinase.
(8) Surprisingly, the clonal elimination of V beta 6+ cells is preceded by marked expansion of these cells.
(9) Muscle weakness and atrophy were most marked in the distal parts of the legs, especially in the gastrocnemius and soleus muscles, and then spread to the thighs and gluteal muscles.
(10) of PLA2 caused marked degranulation of mast cells in the rat mesentery which was facilitated by addition of calcium ion (10 mM) but antagonized by pretreating with three antiinflammatory agents.
(11) report the complications registered, in particular: lead's displacing 6.2%, run away 0.7%, marked hyperthermya 0.0%, haemorrage 0.4%, wound dehiscence 0.3%, asectic necrosis by decubitus 5%, septic necrosis 0.3%, perforation of the heart 0.2%, pulmonary embolism 0.1%.
(12) Marked enhancement of IFN-gamma production by T cells was seen in the presence of as little as 0.3% thymic DC.
(13) This effect was more marked in breast cancer patients which may explain our earlier finding that women with upper body fat localization are at increased risk for developing breast cancer.
(14) Completeness of isolation of the coronary and systemic circulations was shown by the marked difference in appearance times between the reflex hypotensive responses from catecholamine injections into the isolated coronary circulation and the direct hypertensive response from a similar injection when the circulations were connected as well as by the marked difference between the pressure pulses recorded simultaneously on both sides of the aortic balloon separating the two circulations.4.
(15) A marked overlap of input from the two eyes is an unusual feature for a diprotodont marsupial and has previously been seen only in the feathertail glider.
(16) The erythrocyte sedimentation rate is almost always markedly elevated.
(18) Sixteen patients (27%) manifested anomalies of the urinary tract: 12 had markedly altered kidneys, 8 of which were unilateral and ipsilateral to the diaphragmatic defect.
(19) Her muscle weakness and hyperCKemia markedly improved by corticosteroid therapy, suggesting that the diagnosis was compatible with polymyositis (PM).
(20) The introduction of intravenous, high-dose thrombolytic therapy during a brief period has markedly reduced mortality of patients with acute myocardial infarction.