(1) The data were grouped to determine differences between the experimental and the newly revised formats of the GRE-A measure, in addition to any differences among programs.
(2) However, a purified recombinant fragment of the GR which contained essentially only its DNA binding domain was unable to bind at the GME although it interacted strongly with a consensus GRE sequence.
(3) Although GRE images rapidly demonstrated flow in vascular intracranial lesions as high intensity, the vascular nature of these lesions was also clearly evident on SE images in most cases.
(4) We have used cloned rat glucocorticoid-receptor coding sequences to produce and characterize a novel class of receptor mutants that elicit GRE enhancer function in transfected cells even in the absence of hormone.
(5) The MR appearance of thrombosis of the portal vein and its branches using gradient echo (GRE) sequences is described.
(6) Assuming that function as a GRE reflects binding of glucocorticoid receptor, our activity data are consistent with the recognition of the GRE as two hexamer half-sites, each half-site recognized by a single subunit of a receptor dimer, probably in a cooperative fashion.
(7) The sequence recognition by the glucocorticoid receptor at the different defined glucocorticoid regulatory elements (GRE) is discussed and a consensus sequence formulated.
(8) We found that the promoter is extremely G + C rich (72% GC content) and contains a "TAATA" and a "CAT" box, eight "GGGCGG", three "CCGCCC" and two "CACCC" motifs and a motif similar to the glucocorticoid responsive element (GRE) which included two interchanged nucleotides "TCTTGT".
(9) Gel retardation analysis demonstrates that bacterially expressed c-Jun disrupts GR-GRE complexes.
(10) These results demonstrate the importance of GRE consensus sequences in glucocorticoid receptor interactions with DNA, and further identify a cause for high background binding observed when pBR322 DNA is used as a negative control in studies of glucocorticoid receptor-DNA interactions.
(11) Given the "time of flight" effect of GRE sequences, a scan plane perpendicular to the direction of flow was used to obtain maximal signal enhancement of flowing blood.
(12) All pRagCAT constructs in which the 5'-region contained at least one of the two GRE consensus sequences were stimulated by dexamethasone.
(13) Oversaturation (2.0 mumol Fe for SE sequences, greater than or equal to 1.0 mumol Fe for GRE sequences) led to image distortion and did not allow assessment of lymph node morphology.
(14) To accommodate the observed biphasic dose-response curve for highly specific glucocorticoids, and the shift-to-the-left for both classes of effector, we have proposed a model of a single "turn-on" nuclear acceptor site for glucocorticoid receptors (glucocorticoid regulatory element: GRE) and multiple, pre-emptive "turn-off" GREs, occupancy of any one of which will abrogate transcription; for progestins, we propose that all the GRE are alternate "turn-off" sites.
(15) A moderately repetitive DNA sequence, containing a TATA box, a GRE consensus, a Z-DNA forming sequence and two imperfect direct repeats at the extremities, is present a few nucleotides 5' of the human PAI-1 gene transcription start site, raising the possibility that this gene could have been activated by DNA insertion during evolution.
(16) In vitro transcription experiments using a Xenopus laevis cell-free extract have demonstrated that a DNA fragment containing a glucocorticoid response element (GRE) significantly enhances the expression of a methionine tRNA gene.
(17) R1881-activated transcription of a GRE-tk-CAT reporter gene construct was strongly diminished by both mutant receptors and was only partially restored using a 100-fold higher concentration of ligand compared with wild-type receptor.
(18) New cine GRE imaging techniques provide a noninvasive means for quantification of valvular as well as ventricular function.
(19) To investigate the detection of vascular extension of tumor with the GRE technique, findings in the preoperative GRE MR images of 26 patients with renal adenocarcinoma were compared with findings at surgery and pathologic examination.
(20) Our results demonstrate that in-plane GRE imaging and MR angiography can potentially be used as noninvasive methods for evaluating vascular patency in the presence of MR-compatible endovascular devices.
Ogre
Definition:
(n.) An imaginary monster, or hideous giant of fairy tales, who lived on human beings; hence, any frightful giant; a cruel monster.
Example Sentences:
(1) "Then the European commission and the council will start looking like an ogre here, and what the Daily Mail says – which is not true now – about hostility to the Brits inside the institutions will start being true."
(2) To crush any residual affinity for the monarchy, British propaganda against Thibaw “went into high gear”, said Thant Mtint-U, painting the monarch as an ogre, despot and drunkard.
(3) We have constructed a P2 ogr deletion mutant by in vitro techniques.
(4) Phages carrying Cys or Ala in place of Tyr-42 gave burst sizes at least as high as P2 ogr+ in a rpoA+ strain; a Gly substitution also allowed P2 to grow in either a rpoA+ or rpoA109 background, but markedly reduced the burst size.
(5) There, proprietorial and remorselessly downbeat, like the ogre in Shrek, stands MigrationWatch UK.
(6) Essebsi has dismissed the word “taghaoul” (power grab) that the Marzouki camp has deployed, evoking the ogre (“ghoul”) of north African Berber and Arab legend.
(7) The repeat is not present in the promoter region of P2 ogr.
(8) We propose that the P4 delta and P2 ogr gene products bind the -55 region of the P4 and P2 late promoters.
(9) We have inserted the ogr gene into a plasmid under control of the leftward promoter and operator of bacteriophage lambda.
(10) The bacteriophage P2 ogr gene product, a 72-residue basic protein rich in cysteine and histidine, is a positive regulatory factor for phage late gene transcription in both P2 and satellite phage P4.
(11) Thermal induction of ogr gene expression in this plasmid results in overproduction of a small protein that has been shown by complementation to possess Ogr function.
(12) The bacteriophage P2 ogr gene encodes an 8.3-kDa protein that is a positive effector of P2 late gene transcription.
(13) P2 mutants (P2 ogr) able to overcome the gro109 block have been isolated in which synthesis of late P2 mRNA and phage proteins Is restored.
(14) It seems reasonable to assume that mutants which strongly affect development of the imaginal-specific central nervous system may evidence abnormalities during the late larval or pupal stages when the adult central nervous system is undergoing final assembly and might show a lethal phase prior to eclosion (as is true for mutations at the previously defined l(1)ogre locus).
(15) The cryptic ogr genes are constitutively transcribed, apparently at a higher level than the wild-type ogr gene in a P2 lysogen.
(16) We have made null mutants of the P2 ogr and P4 delta genes.
(17) Seen up close in Helsinki earlier this year, Putin did not look the ogre his critics sometimes make him out to be.
(18) The P2 ogr gene encodes a 72-amino-acid protein required for P2 late gene expression.
(19) Neither GDH or OGR mobility alone clearly differentiated all species, but their combined use provided unambiguous discrimination of all species except F. varium and F. mortiferum.
(20) The DNA sequence of the ogr gene containing the ogr1 mutation was determined.